-
1
-
-
84555195746
-
Cardiac models in drug discovery and development: A review
-
R.K. Amanfu, and J.J. Saucerman Cardiac models in drug discovery and development: a review Crit Rev Biomed Eng 39 2011 379 395
-
(2011)
Crit Rev Biomed Eng
, vol.39
, pp. 379-395
-
-
Amanfu, R.K.1
Saucerman, J.J.2
-
2
-
-
0037232739
-
Electrical remodeling of the epicardial border zone in the canine infarcted heart: A computational analysis
-
C. Cabo, and P. Boyden Electrical remodeling of the epicardial border zone in the canine infarcted heart: a computational analysis Am J Physiol Heart Circ Physiol 284 2003 H372 H384
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.284
, pp. 372-H384
-
-
Cabo, C.1
Boyden, P.2
-
3
-
-
74549157674
-
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis
-
M.D. Christensen, W. Dun, P.A. Boyden, M.E. Anderson, P.J. Mohler, and T.J. Hund Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis PLoS Comput Biol 5 2009 e1000583
-
(2009)
PLoS Comput Biol
, vol.5
, pp. 1000583
-
-
Christensen, M.D.1
Dun, W.2
Boyden, P.A.3
Anderson, M.E.4
Mohler, P.J.5
Hund, T.J.6
-
4
-
-
0033527032
-
Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
-
DOI 10.1038/23034
-
C.E. Clancy, and Y. Rudy Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia Nature 400 1999 566 569 (Pubitemid 29381805)
-
(1999)
Nature
, vol.400
, Issue.6744
, pp. 566-569
-
-
Clancy, C.E.1
Rudy, Y.2
-
5
-
-
0037380954
-
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics
-
S. Cortassa, M.A. Aon, E. Marban, R.L. Winslow, and B. O'Rourke An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics Biophys J 84 2003 2734 2755 (Pubitemid 36373594)
-
(2003)
Biophysical Journal
, vol.84
, Issue.4
, pp. 2734-2755
-
-
Cortassa, S.1
Aon, M.A.2
Marban, E.3
Winslow, R.L.4
O'Rourke, B.5
-
6
-
-
0022422465
-
A model of cardiac electrical activity incorporating ionic pumps and concentration changes
-
D. DiFrancesco, and D. Noble A model of cardiac electrical activity incorporating ionic pumps and concentration changes Philos Trans R Soc Lond B Biol Sci 307 1985 353 398
-
(1985)
Philos Trans R Soc Lond B Biol Sci
, vol.307
, pp. 353-398
-
-
Difrancesco, D.1
Noble, D.2
-
7
-
-
0034026881
-
+](i) overloaded cardiac myocytes: A simulation study
-
ioverloaded cardiac myocytes: a simulation study Biophys J 78 2000 2392 2404 (Pubitemid 30313797)
-
(2000)
Biophysical Journal
, vol.78
, Issue.5
, pp. 2392-2404
-
-
Faber, G.M.1
Rudy, Y.2
-
8
-
-
84877579534
-
Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity
-
N. Ferri, P. Siegl, A. Corsini, J. Herrmann, A. Lerman, and R. Benghozi Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity Pharmacol Ther 138 2013 470 484
-
(2013)
Pharmacol Ther
, vol.138
, pp. 470-484
-
-
Ferri, N.1
Siegl, P.2
Corsini, A.3
Herrmann, J.4
Lerman, A.5
Benghozi, R.6
-
9
-
-
0000450921
-
Thresholds and plateaus in the Hodgkin-Huxley nerve equations
-
R. FitzHugh Thresholds and plateaus in the Hodgkin-Huxley nerve equations J Gen Physiol 43 1960 867 896
-
(1960)
J Gen Physiol
, vol.43
, pp. 867-896
-
-
Fitzhugh, R.1
-
10
-
-
53349102813
-
Impulses and physiological states in theoretical models of nerve membrane
-
R.A. FitzHugh Impulses and physiological states in theoretical models of nerve membrane Biophys J 1 1961 445 466
-
(1961)
Biophys J
, vol.1
, pp. 445-466
-
-
Fitzhugh, R.A.1
-
11
-
-
36849057068
-
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials
-
DOI 10.1529/biophysj.107.114868
-
E. Grandi, J.L. Puglisi, S. Wagner, L.S. Maier, S. Severi, and D.M. Bers Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials Biophys J 93 2007 3835 3847 (Pubitemid 350223802)
-
(2007)
Biophysical Journal
, vol.93
, Issue.11
, pp. 3835-3847
-
-
Grandi, E.1
Puglisi, J.L.2
Wagner, S.3
Maier, L.S.4
Severi, S.5
Bers, D.M.6
-
13
-
-
0028297112
-
Application of the three-dimensional structures of protein target molecules in structure-based drug design
-
J. Greer, J.W. Erickson, J.J. Baldwin, and M.D. Varney Application of the three-dimensional structures of protein target molecules in structure-based drug design J Med Chem 37 1994 1035 1054 (Pubitemid 24145364)
-
(1994)
Journal of Medicinal Chemistry
, vol.37
, Issue.8
, pp. 1035-1054
-
-
Greer, J.1
Erickson, J.W.2
Baldwin, J.J.3
Varney, M.D.4
-
14
-
-
0023662820
-
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: Reconstruction of basic cellular mechanisms
-
D.W. Hilgemann, and D. Noble Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms Proc R Soc Lond B Biol Sci 230 1987 163 205
-
(1987)
Proc R Soc Lond B Biol Sci
, vol.230
, pp. 163-205
-
-
Hilgemann, D.W.1
Noble, D.2
-
15
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
A.L. Hodgkin, and A.F. Huxley A quantitative description of membrane current and its application to conduction and excitation in nerve J Physiol 117 1952 500 544
-
(1952)
J Physiol
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
16
-
-
0018860815
-
Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction
-
L. Hondeghem, and B.G. Katzung Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction Circulation 61 1980 1217 1224 (Pubitemid 10116263)
-
(1980)
Circulation
, vol.61
, Issue.6
, pp. 1217-1224
-
-
Hondeghem, L.1
Katzung, B.G.2
-
17
-
-
8744246332
-
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model
-
DOI 10.1161/01.CIR.0000147231.69595.D3
-
T.J. Hund, and Y. Rudy Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model Circulation 110 2004 3168 3174 (Pubitemid 39525061)
-
(2004)
Circulation
, vol.110
, Issue.20
, pp. 3168-3174
-
-
Hund, T.J.1
Rudy, Y.2
-
19
-
-
0031594597
-
2+dynamics: The roles of ryanodine receptor adaptation and sarcoplasmic reticulum load
-
2 +dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load Biophys J 74 1998 1149 1168 (Pubitemid 28108528)
-
(1998)
Biophysical Journal
, vol.74
, Issue.3
, pp. 1149-1168
-
-
Jafri, M.S.1
Rice, J.J.2
Winslow, R.L.3
-
21
-
-
84878624308
-
Role of CaMKII in post acidosis arrhythmias: A simulation study using a human myocyte model
-
E.C. Lascano, M. Said, L. Vittone, A. Mattiazzi, C. Mundina-Weilenmann, and J.A. Negroni Role of CaMKII in post acidosis arrhythmias: a simulation study using a human myocyte model J Mol Cell Cardiol 60 2013 172 183
-
(2013)
J Mol Cell Cardiol
, vol.60
, pp. 172-183
-
-
Lascano, E.C.1
Said, M.2
Vittone, L.3
Mattiazzi, A.4
Mundina-Weilenmann, C.5
Negroni, J.A.6
-
22
-
-
33745338425
-
Hodgkin-Huxley and partially coupled inactivation models yield different voltage dependence of block
-
S. Liu, and R.L. Rasmusson Hodgkin-Huxley and partially coupled inactivation models yield different voltage dependence of block Am J Physiol 272 1997 H2013 H2022
-
(1997)
Am J Physiol
, vol.272
, pp. 2013-H2022
-
-
Liu, S.1
Rasmusson, R.L.2
-
23
-
-
34447525230
-
2 +and electrical alternans in cardiac myocytes: Role of CaMKII and repolarizing currents
-
2 +and electrical alternans in cardiac myocytes: role of CaMKII and repolarizing currents Am J Physiol Heart Circ Physiol 292 2007 H2854 H2866
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
, pp. 2854-H2866
-
-
Livshitz, L.M.1
Rudy, Y.2
-
24
-
-
0028233422
-
A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes
-
C.H. Luo, and Y. Rudy A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes Circ Res 74 1994 1071 1096 (Pubitemid 24176903)
-
(1994)
Circulation Research
, vol.74
, Issue.6
, pp. 1071-1096
-
-
Luo, C.-H.1
Rudy, Y.2
-
25
-
-
84874607556
-
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
-
M. Luo, X. Guan, L. Di, W. Kutschke, Z. Gao, and J. Yang Diabetes increases mortality after myocardial infarction by oxidizing CaMKII J Clin Invest 123 2013 1262 1274
-
(2013)
J Clin Invest
, vol.123
, pp. 1262-1274
-
-
Luo, M.1
Guan, X.2
Di, L.3
Kutschke, W.4
Gao, Z.5
Yang, J.6
-
26
-
-
84867283408
-
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
-
G.R. Mirams, M.R. Davies, Y. Cui, P. Kohl, and D. Noble Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing Br J Pharmacol 167 2012 932 945
-
(2012)
Br J Pharmacol
, vol.167
, pp. 932-945
-
-
Mirams, G.R.1
Davies, M.R.2
Cui, Y.3
Kohl, P.4
Noble, D.5
-
27
-
-
80052358982
-
A computational model to predict the effects of class i anti-arrhythmic drugs on ventricular rhythms
-
J.D. Moreno, Z.I. Zhu, P.C. Yang, J.R. Bankston, M.T. Jeng, and C. Kang A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms Sci Transl Med 3 2011 98ra83
-
(2011)
Sci Transl Med
, vol.3
, pp. 98ra83
-
-
Moreno, J.D.1
Zhu, Z.I.2
Yang, P.C.3
Bankston, J.R.4
Jeng, M.T.5
Kang, C.6
-
28
-
-
36949064203
-
Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations
-
D. Noble Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations Nature 188 1960 495 497
-
(1960)
Nature
, vol.188
, pp. 495-497
-
-
Noble, D.1
-
29
-
-
73849164199
-
A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potential
-
D. Noble A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pacemaker potential J Physiol (Lond) 160 1962 317 352
-
(1962)
J Physiol (Lond)
, vol.160
, pp. 317-352
-
-
Noble, D.1
-
30
-
-
0036901631
-
Modelling the heart: Insights, failures and progress
-
DOI 10.1002/bies.10186
-
D. Noble Modelling the heart: insights, failures and progress Bioessays 24 2002 1155 1163 (Pubitemid 35464945)
-
(2002)
BioEssays
, vol.24
, Issue.12
, pp. 1155-1163
-
-
Noble, D.1
-
32
-
-
0000996439
-
Theory of physiological properties of dendrites
-
W. Rall Theory of physiological properties of dendrites Ann N Y Acad Sci 96 1962 1071 1092
-
(1962)
Ann N y Acad Sci
, vol.96
, pp. 1071-1092
-
-
Rall, W.1
-
33
-
-
0002117770
-
Theoretical significance of dendritic trees for neuronal input-output relations
-
R.F. Reiss, Stanford University Press
-
W. Rall Theoretical significance of dendritic trees for neuronal input-output relations R.F. Reiss, Neuronal theory and modeling 1964 Stanford University Press 73 97
-
(1964)
Neuronal Theory and Modeling
, pp. 73-97
-
-
Rall, W.1
-
34
-
-
0026495474
-
Matching dendritic neuron models to experimental data
-
W. Rall, R.E. Burke, W.R. Holmes, J.J. Jack, S.J. Redman, and I. Segev Matching dendritic neuron models to experimental data Physiol Rev 72 1992 S159 S186
-
(1992)
Physiol Rev
, vol.72
, pp. 159-S186
-
-
Rall, W.1
Burke, R.E.2
Holmes, W.R.3
Jack, J.J.4
Redman, S.J.5
Segev, I.6
-
35
-
-
0025164116
-
A mathematical model of electrophysiological activity in a bullfrog atrial cell
-
R.L. Rasmusson, J.W. Clark, W.R. Giles, K. Robinson, R.B. Clark, and E.F. Shibata A mathematical model of electrophysiological activity in a bullfrog atrial cell Am J Physiol Heart Circ Physiol 259 1990 H370 H389
-
(1990)
Am J Physiol Heart Circ Physiol
, vol.259
, pp. 370-H389
-
-
Rasmusson, R.L.1
Clark, J.W.2
Giles, W.R.3
Robinson, K.4
Clark, R.B.5
Shibata, E.F.6
-
36
-
-
0032876356
-
2+release in the functional unit of the cardiac diadic space
-
2 +release in the functional unit of the cardiac diadic space Biophys J 77 1999 1871 1884 (Pubitemid 29463150)
-
(1999)
Biophysical Journal
, vol.77
, Issue.4
, pp. 1871-1884
-
-
Rice, J.J.1
Jafri, M.S.2
Winslow, R.L.3
-
37
-
-
0040958836
-
Discussion: Electrical excitability of cells, theory and experiment: Review of the Hodgkin-Huxley foundation and an update
-
J. Rinzel Discussion: electrical excitability of cells, theory and experiment: review of the Hodgkin-Huxley foundation and an update Bull Math Biol 52 1990 5 23
-
(1990)
Bull Math Biol
, vol.52
, pp. 5-23
-
-
Rinzel, J.1
-
38
-
-
84867150694
-
Computational approaches to understand cardiac electrophysiology and arrhythmias
-
B.N. Roberts, P.C. Yang, S.B. Behrens, J.D. Moreno, and C.E. Clancy Computational approaches to understand cardiac electrophysiology and arrhythmias Am J Physiol Heart Circ Physiol 303 2012 H766 H783
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.303
, pp. 766-H783
-
-
Roberts, B.N.1
Yang, P.C.2
Behrens, S.B.3
Moreno, J.D.4
Clancy, C.E.5
-
39
-
-
1442306232
-
Drug-Induced Prolongation of the QT Interval
-
DOI 10.1056/NEJMra032426
-
D.M. Roden Drug-induced prolongation of the QT interval N Engl J Med 350 2004 1013 1022 (Pubitemid 38269278)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.10
, pp. 1013-1022
-
-
Roden, D.M.1
-
40
-
-
77953811461
-
The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs
-
B. Rodriguez, K. Burrage, D. Gavaghan, V. Grau, P. Kohl, and D. Noble The systems biology approach to drug development: application to toxicity assessment of cardiac drugs Clin Pharmacol Ther 88 2010 130 134
-
(2010)
Clin Pharmacol Ther
, vol.88
, pp. 130-134
-
-
Rodriguez, B.1
Burrage, K.2
Gavaghan, D.3
Grau, V.4
Kohl, P.5
Noble, D.6
-
41
-
-
33749988979
-
Computational biology in the study of cardiac ion channels and cell electrophysiology
-
DOI 10.1017/S0033583506004227, PII S0033583506004227
-
Y. Rudy, and J.R. Silva Computational biology in the study of cardiac ion channels and cell electrophysiology Q Rev Biophys 39 2006 57 116 (Pubitemid 44566374)
-
(2006)
Quarterly Reviews of Biophysics
, vol.39
, Issue.1
, pp. 57-116
-
-
Rudy, Y.1
Silva, J.R.2
-
42
-
-
84861658382
-
Exploiting mathematical models to illuminate electrophysiological variability between individuals
-
A.X. Sarkar, D.J. Christini, and E.A. Sobie Exploiting mathematical models to illuminate electrophysiological variability between individuals J Physiol 590 2012 2555 2567
-
(2012)
J Physiol
, vol.590
, pp. 2555-2567
-
-
Sarkar, A.X.1
Christini, D.J.2
Sobie, E.A.3
-
43
-
-
0346850834
-
Modeling β-Adrenergic Control of Cardiac Myocyte Contractility in Silico
-
DOI 10.1074/jbc.M308362200
-
J.J. Saucerman, L.L. Brunton, A.P. Michailova, and A.D. McCulloch Modeling beta-adrenergic control of cardiac myocyte contractility in silico J Biol Chem 278 2003 47997 48003 (Pubitemid 37523249)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.48
, pp. 47997-48003
-
-
Saucerman, J.J.1
Brunton, L.L.2
Michailova, A.P.3
McCulloch, A.D.4
-
44
-
-
0032212768
-
Excitable dendrites and spines: Earlier theoretical insights elucidate recent direct observations
-
DOI 10.1016/S0166-2236(98)01327-7
-
I. Segev, and W. Rall Excitable dendrites and spines: earlier theoretical insights elucidate recent direct observations Trends Neurosci 21 1998 453 460 (Pubitemid 28506133)
-
(1998)
Trends in Neurosciences
, vol.21
, Issue.11
, pp. 453-460
-
-
Segev, I.1
Rall, W.2
-
45
-
-
67650469581
-
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential
-
J.R. Silva, H. Pan, D. Wu, A. Nekouzadeh, K.F. Decker, and J. Cui A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential Proc Natl Acad Sci U S A 106 2009 11102 11106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 11102-11106
-
-
Silva, J.R.1
Pan, H.2
Wu, D.3
Nekouzadeh, A.4
Decker, K.F.5
Cui, J.6
-
46
-
-
0021210880
-
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics
-
C.F. Starmer, A.O. Grant, and H.C. Strauss Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics Biophys J 46 1984 15 27 (Pubitemid 14059133)
-
(1984)
Biophysical Journal
, vol.46
, Issue.1
, pp. 15-27
-
-
Starmer, C.F.1
Grant, A.O.2
Strauss, H.C.3
-
47
-
-
79961015131
-
Oxidized CaMKII causes sinus node dysfunction in mice
-
P.D. Swaminathan, A. Purohit, S. Soni, N. Voigt, M.V. Singh, and A.V. Glukhov Oxidized CaMKII causes sinus node dysfunction in mice J Clin Invest 121 2011 3277 3288
-
(2011)
J Clin Invest
, vol.121
, pp. 3277-3288
-
-
Swaminathan, P.D.1
Purohit, A.2
Soni, S.3
Voigt, N.4
Singh, M.V.5
Glukhov, A.V.6
-
48
-
-
84862296973
-
Calmodulin-dependent protein kinase II: Linking heart failure and arrhythmias
-
P.D. Swaminathan, A. Purohit, T.J. Hund, and M.E. Anderson Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias Circ Res 110 2012 1661 1677
-
(2012)
Circ Res
, vol.110
, pp. 1661-1677
-
-
Swaminathan, P.D.1
Purohit, A.2
Hund, T.J.3
Anderson, M.E.4
-
49
-
-
79251636579
-
Whole-heart modeling: Applications to cardiac electrophysiology and electromechanics
-
N.A. Trayanova Whole-heart modeling: applications to cardiac electrophysiology and electromechanics Circ Res 108 2011 113 128
-
(2011)
Circ Res
, vol.108
, pp. 113-128
-
-
Trayanova, N.A.1
-
50
-
-
0032979304
-
Pause induced early afterdepolarizations in the long QT syndrome: A simulation study
-
DOI 10.1016/S0008-6363(99)00035-8, PII S0008636399000358
-
P. Viswanathan, and Y. Rudy Pause induced early afterdepolarizations in the long QT syndrome: a simulation study Cardiovasc Res 42 1999 530 542 (Pubitemid 29243178)
-
(1999)
Cardiovascular Research
, vol.42
, Issue.2
, pp. 530-542
-
-
Viswanathan, P.C.1
Rudy, Y.2
-
52
-
-
0029024749
-
+current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization
-
+current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization Circ Res 77 1995 140 152
-
(1995)
Circ Res
, vol.77
, pp. 140-152
-
-
Zeng, J.1
Laurita, K.R.2
Rosenbaum, D.S.3
Rudy, Y.4
|