Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions

Biochemistry

Volumn 50, Issue 13, 2011, Pages 2683-2690

  Khersonsky, Olga ^a,b   Malitsky, Sergey ^a   Rogachev, Ilana ^a   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME FUNCTIONS; NATURALLY OCCURRING; PHOSPHATE GROUP; PROTEOMES; REACTION CHEMISTRY; SUBSTRATE BINDING; SUBSTRATE MOTIFS; XENOBIOTIC SUBSTRATES;

CATALYSTS; ENZYMES; ESCHERICHIA COLI; POLYPEPTIDES;

SUBSTRATES;

3 PHOSPHOPROPYL 4 NITROPHENYL METHYL PHOSPHONATE; 4 NITROPHENYL ACETATE; 5 NITROBENZISOXAZOLE; 6 PHOSPHOBENZISOXAZOLE; BACTERIAL ENZYME; PHOSPHONOESTERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME CHEMISTRY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

BIOCATALYSIS; ESCHERICHIA COLI K12; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; PROTEOME; SUBSTRATE SPECIFICITY; XENOBIOTICS;

ESCHERICHIA COLI;

EID: 79953166401     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101763c     Document Type: Article

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