Atrial natriuretic peptide: An old hormone or a new cytokine?

Peptides

Volumn 58, Issue , 2014, Pages 108-116

  De Vito, Paolo ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Atrial natriuretic peptide; Cell proliferation; Cytokines; Cytoprotective effects; Reactive oxygen species

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CYCLIC AMP; CYCLIC GMP; CYCLOOXYGENASE 2; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HORMONE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; WATER; PTGS2 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANTIPROLIFERATIVE ACTIVITY; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; CANCER CELL; CANCER GROWTH; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL GROWTH; CELL PROTECTION; ENDOTHELIUM CELL; FLUID BALANCE; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HOST RESISTANCE; HUMAN; HYPERTENSION; IMMUNOMODULATION; INNATE IMMUNITY; LIVER PROTECTION; LYMPHOCYTE DIFFERENTIATION; OXIDATIVE STRESS; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SODIUM BALANCE; VASCULAR SMOOTH MUSCLE; ANIMAL; IMMUNOLOGY; PHYSIOLOGY; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ANIMALS; ATRIAL NATRIURETIC FACTOR; CYCLOOXYGENASE 2; CYTOKINES; HUMANS; IMMUNITY, INNATE; NITRIC OXIDE; TH17 CELLS; TH2 CELLS;

EID: 84905961459     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2014.06.011     Document Type: Review

References (121)

1. Z. Abassi, T. Karram, S. Ellaham, J. Winaver, and A. Hoffman Implications of the atrial natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance Pharmacol Ther 102 2004 223 241 (Pubitemid 38887694)
2. T. Agui, X. Xin, Y. Cai, G. Shim, Y. Muramatsu, and T. Yamada et al. Opposite actions of transforming growth factor-β1 on the gene expression of atrial natriuretic peptide biological and clearance receptors in a murine thymic stromal cell line J Biochem 118 1995 500 507
3. M.B. Anand-Srivastava, and G.J. Tracte Atrial natriuretic factor receptors and signal transduction mechanism Pharmacol Rev 45 1993 455 497 (Pubitemid 24015112)
4. P.M. Baldini, P. De Vito, D. Antenucci, D. Vismara, F. D'Aquilio, and P. Luly et al. Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase Cell Death Diff 11 2004 S210 S212
5. P.M. Baldini, P. De Vito, F. D'Aquilio, D. Vismara, F. Zalfa, and C. Bagni et al. Role of atrial natriuretic peptide in the suppression of lysophosphatidic acid-induced rat aortic smooth muscle (RASM) cell growth Mol Cell Biochem 272 2005 19 28 (Pubitemid 40867361)
6. P.M. Baldini, P. De Vito, M. Fraziano, P. Mattiolo, P. Luly, and P. Di Nardo Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells J Cell Physiol 193 2002 103 109 (Pubitemid 34969133)
7. P.M. Baldini, P. De Vito, A. Martino, M. Fraziano, C. Grimaldi, and P. Luly et al. Differential sensitivity of human monocytes and macrophages to ANP: a role of intracellular pH on reactive oxygen species production through the phospholipase involvement J Leukoc Biol 73 2003 502 510 (Pubitemid 38040096)
8. P.M. Baldini, P. De Vito, D. Vismara, C. Bagni, F. Zalfa, and M. Minieri et al. Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HepG2 cells: role of p38MAPK and phospholipase D Cell Physiol Biochem 15 2005 77 88
9. P.M. Baldini, A. Lentini, P. Mattioli, B. Provenzano, P. De Vito, and D. Vismara et al. Decrease of polyamine levels and enhancement of transglutaminase activity in selective reduction of B16-F10 melanoma cell proliferation induced by atrial natriuretic peptide Melanoma Res 16 2006 501 507 (Pubitemid 44934708)
10. T. Balong, T. Marotti, M. Abramic, I. Bensan-Svoboda, S. Sobocanee, and I. Hrsak Neutrophils neutral endopeptidase variation and its regulation by opiod peptides Int Immunopharmacol 1 2001 569 579 (Pubitemid 32197554)
11. B.C. Berk Vascular smooth muscle growth: autocrine growth mechanisms Physiol Rev 81 2001 999 1030 (Pubitemid 32606665)
12. M. Bilzer, H. Jaeschke, A.M. Vollmar, G. Paumangartner, and A.L. Gerbes Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide Am J Physiol 276 1999 G1137 G1144
13. M. Bilzer, F. Roggel, and A.L. Gerbes Role of Kupffer cell in host defense and liver disease Liver Int 26 2006 1175 1186 (Pubitemid 44741204)
14. R. Biselli, S. Farrace, C. De Simone, and A. Fattorossi Potentiation of human polymorphonuclear leukocyte activation by atrial natriuretic peptide. Inhibitory effects of carnitine congeners Inflammation 20 1996 33 42
15. B.M. Brenner, B.J. Ballerman, M.E. Gunning, and M.L. Ziedel Diverse biological actions of atrial natriuretic peptide Physiol Rev 70 1990 655 699
16. R. Carini, M.G. De Cesaris, R. Splendore, C. Domenicotti, M.P. Nitti, and M.A. Pronzato et al. Mechanism of hepatocyte protection against hypoxic injury by atrial natriuretic peptide Hepatology 37 2003 277 285 (Pubitemid 36152526)
17. B.P. Casserly, E.H. Sears, and E.J. Gartman The role of natriuretic peptides in inflammation and immunity Recent Pat Inflamm Allergy Drug Discov 4 2010 90 104
18. P.A. Chail, and A. Hassid Differential antimitogenic effectiveness of atrial natriuretic peptides in primary vs. subcultured rat aortic smooth muscle cells: relationship to expression of ANF-C receptors J Cell Physiol 154 1993 28 38 (Pubitemid 23023992)
19. Y.F. Chen Atrial natriuretic peptide in hypoxia Peptides 26 2005 1068 1077
20. 2+ changes in rat aortic smooth muscle cells. The role of atrial natriuretic peptide Moll Cell Biochem 252 2003 353 362 (Pubitemid 37220766)
21. P. De Vito, S. Incerpi, E. Affabris, Z. Percario, M. Borgatti, and R. Gambari et al. Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokines release Peptides 50 2013 100 108
22. P. De Vito, S. Incerpi, J.Z. Pedersen, and P. Luly Atrial natriuretic peptide and oxidative stress Peptides 31 2010 1412 1429
23. P. De Vito The sodium/hydrogen exchanger: a possible mediator of immunity Cell Immunol 240 2006 69 85 (Pubitemid 44353444)
24. L.A. Fouser, J.F. Wright, K. Dunussi-Joannopoulus, and M. Collins Th17 cytokines and their emerging roles in inflammation and autoimmunity Immunol Rev 226 2008 87 102
25. Y. Fujii, K. Ishino, T. Tomii, H. Kanamitsu, Y. Fujita, and H. Mitsui et al. Atrionatriuretic peptide improves left ventricular function after myocardial global ischemia-reperfusion in hypoxic hearts Artif Organs 36 2012 379 386
26. R. Furst, C. Brueckl, W.M. Kuebler, S. Zahler, F. Krotz, and A. Gorlach et al. Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation Circ Res 96 2005 43 53 (Pubitemid 40095753)
27. D.J. Glenn, D. Rahmutula, M. Nishimoto, F. Liang, and D.G. Gardner Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblast through a GATA4-dependent mechanism Cardiovasc Res 84 2009 209 217
28. U. Grutzner, M. Keller, M. Bach, A.K. Kiemer, H. Meissner, and M. Bilzer et al. Pi 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation World J Gastroenterol 12 2006 1049 1055
29. J. Gugenheim Atrial natriuretic peptide (ANP) preconditioning: what is the relevance of the antiapoptotic effects J Hepatol 39 2003 428 430 (Pubitemid 37070261)
30. D.J. Hausenloy, and D.M. Yellon Myocardial ischemia-reperfusion injury: a neglected therapeutic target J Clin Invest 123 2013 92 100
31. D. Hayashi, S. Kundoh, I. Shojima, Y. Zou, K. Harada, and M. Shimoyama et al. Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1 Biochem Biophys Res Commun 322 2004 310 319 (Pubitemid 39093871)
32. S. Hayek, and M. Nemer Cardiac natriuretic peptides: from basic discovery to clinical practice Cardiovasc Ther 29 2011 362 376
33. K.S. Heinze, A.L. Gerbes, T. Gerwig, A.M. Vollmar, and A.K. Kiemer Protein kinase A dependent signaling mediates anti-apoptotic effects of the atrial natriuretic peptide in ischemic livers J Hepatol 41 2004 414 420 (Pubitemid 39158750)
34. T. Horio, T. Nishikimi, F. Yoshihara, H. Matsuo, S. Takishita, and K. Kangawa Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured myocytes Hypertension 35 2000 19 24 (Pubitemid 30054231)
35. - exchange Eur J Cancer 29 1993 132 137
36. C. Hurtado, and G.N. Pierce Sodium-hydrogen exchange inhibition: prevents post ischemic treatment Basic Res Cardiol 96 2001 312 317 (Pubitemid 32700567)
37. N. Ishigaki, N. Yamamoto, H. Jin, K. Uchida, S. Terai, and I. Sakaida Continuous intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat Biochem Byophys Res Commun 378 2009 354 359
38. I. Iwamoto, A. Kimura, K. Ochiaik, H. Tomioka, and S. Yoshida Distribution of neutral endopeptidases activity in human blood leukocytes J Leukoc Biol 49 1991 116 125
39. S. Javadov, V. Rajapurohitam, A. Kilic, A. Zeidan, A. Choi, and M. Karmazyn Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3-beta-dependent attenuation of mitochondrial dysfunction J Moll Cell Cardiol 46 2009 998 1007
40. M.L. Kapsenberg Dendritic-cell control of pathogen-driving T-cell polarization Nat Rev Immunol 3 2003 984 993 (Pubitemid 37521540)
41. T. Kato, J. Muraski, Y. Chen, Y. Tsujita, J. Wall, and C.C. Glembotski et al. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt J Clin Invest 115 2005 2716 2730 (Pubitemid 41434399)
42. A.K. Kiemer, N. Bildner, N.C. Weber, and A.M. Vollmar Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in endothelial cells Endocrinology 144 2003 802 812 (Pubitemid 36262847)
43. A.K. Kiemer, A.L. Gerbers, M. Bilzer, and A.M. Vollmar The atrial natriuretic peptide and cGMP: novel activators of the heat shock response in rat livers Hepatology 35 2002 88 94 (Pubitemid 34032547)
44. A.K. Kiemer, T. Hartung, and A.M. Vollmar cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages J Immunol 165 2000 175 181 (Pubitemid 30429505)
45. A.K. Kiemer, S. Kulhanek-Heinze, T. Gerwig, A.L. Gerbes, and A.M. Vollmar Stimulation of p38 MAPK by hormonal preconditioning with atrial natriuretic peptide World J Gastroenterol 8 2002 707 711 (Pubitemid 34918668)
46. A.K. Kiemer, M.D. Lehner, T. Hartung, and A.M. Vollmar Inhibition of cyclooxygenase-2 by natriuretic peptides Endocrinology 143 2002 846 852 (Pubitemid 34164034)
47. A.K. Kiemer, A.M. Vollmar, M. Bilzer, T. Gerwig, and A.L. Gerbers Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kB and AP-1 J Hepatol 33 2000 236 246 (Pubitemid 30485227)
48. A.K. Kiemer, and A.M. Vollmar Autocrine regulation of inducible nitric oxide synthase in macrophages by atrial natriuretic peptide J Biol Chem 273 1998 13444 13451 (Pubitemid 28268383)
49. A.K. Kiemer, and A.M. Vollmar Elevation of intracellular calcium levels contributes to the inhibition of inducible nitric oxide synthase by atrial natriuretic peptide Immunol Cell Biol 79 2001 11 17 (Pubitemid 32158169)
50. A.K. Kiemer, and A.M. Vollmar Induction of l-arginine transport is inhibited by ANP: a peptide hormone as novel regulator of iNOS substrate availability Mol Pharmacol 60 2001 421 426 (Pubitemid 32781547)
51. A.K. Kiemer, N.C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze, and A.M. Vollmar Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-α-induced actin polymerization and endothelial permeability Circ Res 90 2002 874 881 (Pubitemid 34633879)
52. + exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice Circulation 112 2005 2307 2317 (Pubitemid 41464574)
53. I. Kishimoto, T. Tokudome, T. Horio, D.L. Garbers, K. Nakao, and K. Kangawa Natriuretic peptide signaling via guanylyl cyclase (GC)-A: an endogenous protective mechanism of the heart Curr Cardiol Rev 5 2009 45 51
54. S. Kitashiro, T. Sugura, Y. Takayama, Y. Tsuka, T. Izuoka, and S. Tokunaga et al. Long-term administration of atrial natriuretic peptide in patients with acute heart failure J Cardiovas Pharmacol 33 1999 948 952 (Pubitemid 29242778)
55. Y. Kobayashi The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation J Leukoc Biol 88 2010 1157 1162
56. X. Kong, X. Wang, W. Xu, S. Beheras, G. Hellerman, and A. Kumar et al. Natriuretic peptide receptor as a novel anticancer target Cancer Res 68 2008 249 256 (Pubitemid 351380126)
57. H. Kook, H. Itoh, B.S. Choi, N. Sawada, K. Doi, and T.J. Hwang et al. Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro Am J Physiol Heart Circ Physiol 284 2003 H1388 H1397
58. J. Kourie Interaction of reactive oxygen species with ion transport mechanism Am J Physiol 275 1998 C1 C24
59. C. Kunsch, and R.M. Medford Oxidative stress is a regulator of gene expression in the vasculature Circ Res 85 1999 753 766 (Pubitemid 29480816)
60. M. Kurihara, S. Katamine, and J.M. Saavedra Atrial natriuretic peptide, ANP (99-126), receptors in rat thymocytes and spleen cells Biochem Biophys Res Commun 145 1987 789 796 (Pubitemid 17093517)
61. M. Kurihara, K. Sigematsu, and J.M. Saavedra Localization of atrial natriuretic peptide, ANP (99-126) binding sites in the rat thymus and spleen with quantitative autoradiography Regul Pept 15 1986 341 346 (Pubitemid 17178760)
62. L. Li Regulation of innate immunity signaling and its connection with human disease Curr Drug Inflamm Allergy 3 2004 81 86 (Pubitemid 38854892)
63. M.A. Libing, L. Jinxiu, W. Guyi, G. Subo, Z. Li, and K. Li et al. Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-akt signaling pathways Regul Pept 181 2013 9 16
64. T. Lyu, Y. Zhao, T. Zhang, W. Zhou, F. Yang, and H. Ge et al. Natriuretic peptides as an adjunctive treatment for acute myocardial infarction Int Heart J 55 2014 8 16
65. J.A. Madden, P.A. Keller, and G. Kleinman Changes in smooth muscle cell pH during hypoxic pulmonary vasoconstriction: a possible role for ion transporters Physiol Rev 49 2000 561 566
66. J. Malella, S. Ravi, F.J. Louis, B. Mulaney, M. Cheung, and U.S. Garapati et al. Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation tumorigenesis Stem Cells 31 2013 1321 1329
67. N.J. Manimala, D.C. Frost, M.L. Lane, M. Higuera, R. Beg, and D.L. Vesely Cardiac hormones target nuclear oncogenes c-Fos and c-Jun in carcinoma cells Eur J Clin Invest 43 2013 1156 1162
68. R.B. Marala, and R.K. Sharma Three immunologically similar atrial natriuretic factor receptors Mol Cell Biochem 109 1992 71 75
69. J. Mattana, and P.C. Singhal Effects of atrial natriuretic peptide and cGMP on uptake of IgG complexes by macrophages Am J Physiol 265 1993 C92 C98
70. K.S. Misono Natriuretic peptide receptor: structure and signaling Mol Cell Biochem 230 2002 49 60 (Pubitemid 34257241)
71. R. Morita, T. Fujita, T. Uchiyama, and T. Hori Human plasmacytoid dendritic cells express an atrial natriuretic receptor, guanylyl cyclase-A Microbiol Immunol 53 2009 403 411
72. R. Morita, N. Ukyo, M. Furuya, T. Uchiyama, and T. Hori Atrial natriuretic peptide polarizes human dendritic cells toward a Th2-promoting phenotype through its receptor guanylyl cyclase-coupled receptor A J Immunol 170 2003 5869 5875 (Pubitemid 36682565)
73. B.R. Moss, and M.G. Golightly In vitro enhancement of natural cytotoxicity by atrial natriuretic peptide fragment 4-28 Peptides 12 1991 851 854
74. E.M. Mtairaq, X. Hourard, S. Rais, C. Pasquier, M. Oudghiri, and M.P. Jacob et al. Pharmacological potentiation on natriuretic peptide limits polymorphonuclear neutrophil-vascular cell interaction Arterioscler Thromb Vasc Biol 22 2002 1824 1831 (Pubitemid 35315768)
75. T. Murohara, K. Kugiyara, Y. Ota, H. Doi, N. Ogata, and M. Ohgushi et al. Effects of atrial and brain natriuretic peptides on lysophosphatidylcholine- mediated endothelial dysfunction J Cardiovasc Pharmacol 34 1999 870 888
76. J. Nawarskas, V. Rajan, and W.H. Frishman Vasopeptidase inhibitors, neutral endopeptidase inhibitors, and dual inhibitors of angiotensin-converting and neutral endopeptidase Heart Dis 3 2001 378 385 (Pubitemid 34003378)
77. B. Nicholson, C.K. Mannerm, J. Kleeman, and C.L. MacLeod Sustained nitric oxide production in macrophages requires the arginine transporter Cat2 J Biol Chem 276 2001 15881 15885
78. P.F. O'Tierney, N.N. Chattergoon, S. Louey, G.D. Giraud, and K.L. Thornburg Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes J Physiol 588 2010 2879 2889
79. P. Parham, and A. Hoffet Variable NK cell receptors and their MHC class I ligands in immunity reproduction and human evolution Nat Rev Immunol 13 2013 133 144
80. A. Pedram, M. Razandi, and E.R. Levin Natriuretic peptides suppress vascular endothelial growth factor signaling to angiogenesis Endocrinology 142 2001 1578 1586 (Pubitemid 32299687)
81. L.R. Potter Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases Pharmacol Ther 130 2011 71 82
82. L.R. Potter, A.R. Yoder, D.R. Flora, L.K. Antos, and D.M. Dickey Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications Handb Exp Pharmacol 191 2009 341 366
83. N. Rafat, B. Tonshoff, A. Bierhaus, and G.C. Beck Endothelial progenitor cells in regeneration after acute lung injury: do they play a role Am J Respir Cell Mol Biol 48 2013 399 405
84. H.M. Rashed, H. Sun, and T.B. Patel Atrial natriuretic peptide inhibits growth of hepatoblastoma (HEP G2) cells by means of activation of clearance receptors Hepatology 17 1993 677 684 (Pubitemid 23115515)
85. T.J. Reape, and P.H. Groot Chemokines and atherosclerosis Atherosclerosis 147 1999 213 225 (Pubitemid 29512252)
86. R. Ricci, P.M. Baldini, L. Bogetto, P. De Vito, P. Luly, and A. Zannetti et al. Dual modulation of Na/H antiport by atrial natriuretic factor in rat aortic smooth muscle cells Am J Physiol 273 1997 C643 C652
87. R.H. Richie Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes Cardiovasc Res 72 2006 112 123
88. S. Rubattu, S. Sciaretta, A. Morriello, C. Calvieri, A. Battistoni, and M. Volpe NPR-C: a component of the natriuretic peptide family with implication in disease J Mol Med 88 2010 889 897
89. S. Rubattu, and M. Volpe The atrial natriuretic peptide: a changing view J Hypertens 19 2001 1923 1931 (Pubitemid 33035796)
90. A. Saggini, A. Anogeianaki, G. Maccauro, S. Tetè, V. Salini, and A. Caraffa et al. Cholesterol, cytokines and diseases Int J Immunopathol Pharmacol 24 2001 567 581
91. Y. Saito Roles of atrial natriuretic peptide and its therapeutic use J Cardiol 56 2010 262 270
92. B.H. Segal, M.J. Grimm, A.N. Khan, W. Han, and T.S. Blackwell Regulation of innate immunity by NADPH oxidase Free Radic Biol Med 53 2012 72 80
93. A. Serafino, N. Moroni, R. Psaila, M. Zonfrillo, F. Andreola, and F. Wannenes et al. Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β signaling Biochim Biophys Acta 1822 2012 1004 1018
94. A. Serafino, and P. Pierimarchi Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators Curr Med Chem 2014 10.2174/0929867321666140205140152
95. W.P. Skelton, G.E. Pi, and D.L. Vesely Four cardiac hormones cause death of human cancer cell but not of healthy cells Anticancer Res 31 2001 395 402
96. A.H. Sprague, and R.A. Khalil Inflammatory cytokines in vascular dysfunction and vascular disease Biochem Pharmacol 78 2009 539 552
97. 2+ efflux via plasma membrane recruitment of PKG alpha Biochem Biophys Res Commun 368 2008 965 970
98. N. Suenobu, M. Shichiri, M. Iwashima, F. Marumo, and Y. Hirata Natriuretic peptides and nitric oxide induce endothelial apoptosis via a cGMP-dependent mechanism Arteroscler Thromb Vasc Biol 19 1999 140 146 (Pubitemid 29031922)
99. N. Takashi, H. Hosada, T. Tokudome, K. Miura, S. Ishikane, and T. Kimura et al. Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury Pulm Pharmacol Ther 20 2014 1 7
100. S. Tetè, D. Tripodi, M. Rosati, F. Conti, G. Maccuro, and A. Saggini et al. Endothelial cells, cholesterol, cytokines and aging Int J Immunophatol Pharmacol 25 2012 355 363
101. M. Throsby, D. Lee, W. Huang, Z. Yang, D.L. Copolov, and A.T. Lim Evidences for atrial natriuretic peptide (5-28) production by macrophages of the rat spleen: an immunochemical and nonradiactive in situ hybridization approach Endocrinology 129 1991 991 1000
102. H. Tsukagoshi, Y. Shimizu, T. Kawata, T. Hisada, Y. Shimuzu, and S. Iwamae et al. Atrial natriuretic peptide inhibits tumor necrosis factor-alpha production by interferon-gamma-activated macrophages via suppression of p38 mitogen-activated protein kinase and nuclear factor kappa B activation Regul Pept 99 2001 21 29 (Pubitemid 32232124)
103. D.L. Vesely Natriuretic peptides metabolic targets for treatment of cancer J Invest Med 61 2013 816 822
104. A.M. Vollmar, F. Colbatzky, and R. Schultz Increased production of atrial natriuretic peptide in the rat thymus irradiation Immunopharmacology 26 1993 65 72 (Pubitemid 23216874)
105. A.M. Vollmar, R. Forster, and R. Schultz Effects of atrial natriuretic peptide on phagocytosis and respiratory burst in murine macrophages Eur J Pharmacol 319 1997 279 285 (Pubitemid 27056050)
106. A.M. Vollmar, G. Paumgartner, and A.L. Gerbes Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver Gut 40 1997 145 150 (Pubitemid 27079767)
107. A.M. Vollmar, K.N. Schmidt, and R. Schulz Natriuretic peptide receptors on rat thymocytes: inhibition of proliferation by atrial natriuretic peptide Endocrinology 137 1996 1706 1713 (Pubitemid 26133945)
108. A.M. Vollmar, and R. Schultz Expression and differential regulation of natriuretic peptides in mouse macrophages J Clin Invest 95 1995 2442 2450
109. A.M. Vollmar Atrial natriuretic peptide in peripheral organs other than heart Klin Wochenschr 68 1990 699 708 (Pubitemid 20213646)
110. A.M. Vollmar Influence of atrial natriuretic peptide on thymocyte development in fetal thymic organ culture J Neuroimmunol 78 1997 90 96 (Pubitemid 27394429)
111. A.M. Vollmar, and R. Schultz Atrial natriuretic peptide is synthesized in the human thymus Endocrinology 126 1990 2277 2280 (Pubitemid 20173009)
112. A.M. Vollmar The role of atrial natriuretic peptide in immune system Peptides 26 2005 1086 1094 (Pubitemid 40725379)
113. N.C. Weber, S.B. Blumenthal, T. Hartung, A.M. Vollmar, and A.K. Kiemer ANP inhibits TNF-aplha-induced endothelial MCP-1 expression-involvement of p38 MAPK and MKP-1 J Leuk Biol 74 2003 932 941 (Pubitemid 38040370)
114. C.J. Wiedermann, M. Niedermuhlbivhler, and H. Braunsteiner Priming of polymorphonuclear neutrophils by atrial natriuretic peptide in vitro J Clin Invest 74 1992 932 941
115. S. Wray Smooth muscle intracellular pH: measurements, regulation and function Am J Physiol 254 1988 C213 C225
116. C.F. Wu, N.H. Bishopric, and R.E. Pratt Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes J Biol Chem 272 1997 14860 14866 (Pubitemid 27251756)
117. J. Xing, and A.A. Birukova ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFalpha Microvasc Res 79 2010 56 62
118. J. Zhang, Z. Zhao, C. Zu, H. Hu, H. Shen, and H. Zhang et al. Atrial natriuretic peptide modulates the proliferation of human gastric cancer cell via KCNQ1 expression Oncol Let 6 2013 407 414
119. Q.L. Zhang, B. Cui, H. Li, P. Li, L. Hong, and P. Liu et al. MAPK and PI3K pathway regulate hypoxia-induced atrial natriuretic peptide secretion by controlling HIF-1 alpha expression in beating rabbit atria Biochem Biophys Res Commun 438 2013 507 512
120. W. Zhang, X. Cao, D. Chen, J.W. Wang, H. Yang, and W. Wang et al. Plasmid-encoded NP 73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells Genet Vaccines Ther 9 2001 3 12
121. Y.B. Zhu, Y.B. Zhang, D.H. Liu, X.F. Li, A.J. Liu, and X.M. Fan et al. Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats Chin Med J 126 2013 747