Endothelial progenitor cells in regeneration after acute lung injury: Do they play a role?

American Journal of Respiratory Cell and Molecular Biology

Volumn 48, Issue 4, 2013, Pages 399-405

  Rafat, Neysan ^a   Tönshoff, Burkhard ^a   Bierhaus, Angelika ^b   Beck, Grietje C ^c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c DR HORST SCHMIDT KLINIKEN   (Germany)

Author keywords

Acute lung injury; Endothelial progenitor cells; Endothelial regeneration; Neovascularization

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; CD133 ANTIGEN; CD34 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CXCR4; CYTOKERATIN; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SCATTER FACTOR; SOMATOMEDIN C; STEM CELL ANTIGEN 1; STROMAL CELL DERIVED FACTOR 1; THROMBIN; VASCULOTROPIN; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 2;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE MARROW DERIVED PROGENITOR CELL; BONE MARROW TRANSPLANTATION; BONE TRANSPLANTATION; CELL CULTURE; CELL POPULATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG BIOPSY; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PULMONARY MICROVASCULAR ENDOTHELIAL CELL; RAT; RETROSPECTIVE STUDY; REVIEW; STEM CELL; TISSUE REGENERATION; UPREGULATION; ANIMAL; BIOLOGICAL THERAPY; BONE MARROW CELL; ENDOTHELIUM CELL; METABOLISM; PATHOLOGY; REGENERATION; STEM CELL TRANSPLANTATION; TRANSPLANTATION;

ACUTE LUNG INJURY; ANIMALS; BONE MARROW CELLS; ENDOTHELIAL CELLS; HUMANS; REGENERATION; RESPIRATORY DISTRESS SYNDROME, ADULT; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE THERAPY;

MLCS; MLOWN;

EID: 84878244516     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0132TR     Document Type: Review

References (61)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342: 1334-1349.
2. Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med 2006;27: 337-349.
3. Mutunga M, Fulton B, Bullock R, Batchelor A, Gascoigne A, Gillespie JI, Baudouin SV. Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 2001;163: 195-200.
4. Orfanos SE, Mavrommati I, Korovesi I, Roussos C. Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 2004;30: 1702-1714.
5. Goon PK, Boos CJ, Lip GY. Circulating endothelial cells: markers of vascular dysfunction. Clin Lab 2005;51: 531-538.
6. Liu HL, Zhao JY. Study on the changes in circulating endothelial cells and hemorheology of lung in rats with acute lung injury by chemicals Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2003;21: 37-40.
7. Re F, Zanetti A, Sironi M, Polentarutti N, Lanfrancone L, Dejana E, Colotta F. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 1994;127: 537-546.
8. Ballieux BE, Hiemstra PS, Klar-Mohamad N, Hagen EC, van Es LA, van der Woude FJ, Daha MR. Detachment and cytolysis of human endothelial cells by proteinase 3. Eur J Immunol 1994;24: 3211-3215.
9. Ruegg C, Yilmaz A, Bieler G, Bamat J, Chaubert P, Lejeune FJ. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFNgamma. Nat Med 1998;4: 408-414.
10. Dimmeler S, Hermann C, Galle J, Zeiher AM. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosissuppressive effects of shear stress on endothelial cells. Arterioscler Thromb Vasc Biol 1999;19: 656-664.
11. Mancuso P, Calleri A, Cassi C, Gobbi A, Capillo M, Pruneri G, Martinelli G, Bertolini F. Circulating endothelial cells as a novel marker of angiogenesis. Adv Exp Med Biol 2003;522: 83-97.
12. Yoder MC, Mead LE, Prater D, Krier TR, Mroueh KN, Li F, Krasich R, Temm CJ, Prchal JT, Ingram DA. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007;109: 1801-1809.
13. Ingram DA, Mead LE, Moore DB, Woodard W, Fenoglio A, Yoder MC. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood 2005;105: 2783-2786.
14. Ingram DA, Mead LE, Tanaka H, Meade V, Fenoglio A, Mortell K, Pollok K, Ferkowicz MJ, Gilley D, Yoder MC. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004;104: 2752-2760.
15. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275: 964-967.
16. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348: 593-600.
17. Ghani U, Shuaib A, Salam A, Nasir A, Shuaib U, Jeerakathil T, Sher F, O'Rourke F, Nasser AM, Schwindt B, et al. Endothelial progenitor cells during cerebrovascular disease. Stroke 2005;36: 151-153.
18. Rafat N, Beck GC, Pena-Tapia PG, Schmiedek P, Vajkoczy P. Increased levels of circulating endothelial progenitor cells in patients with moyamoya disease. Stroke 2009;40: 432-438.
19. Rafat N, Hanusch C, Brinkkoetter PT, Schulte J, Brade J, Zijlstra JG, van der Woude FJ, Van Ackern, Yard BA, Beck GC. Increased circulating endothelial progenitor cells in septic patients: correlation with survival. Crit Care Med 2007;35: 1677-1684.
20. Rafat N, Beck GC, Schulte J, Tuettenberg J, Vajkoczy P. Circulating endothelial progenitor cells in malignant gliomas. J Neurosurg 2010;112: 43-49.
21. Nowak K, Rafat N, Belle S, Weiss C, Hanusch C, Hohenberger P, Beck GC. Circulating endothelial progenitor cells are increased in human lung cancer and correlate with stage of disease. Eur J Cardiothorac Surg 2010;37: 758-763.
22. Voswinckel R, Ziegelhoeffer T, Heil M, Kostin S, Breier G, Mehling T, Haberberger R, Clauss M, Gaumann A, Schaper W, et al. Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circ Res 2003;93: 372-379.
23. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ,Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, et al. Expression of VEGFR-2 and AC133 by circulating human CD34(1) cells identifies a population of functional endothelial precursors. Blood 2000;95: 952-958.
24. Case J, Mead LE, Bessler WK, Prater D, White HA, Saadatzadeh MR, Bhavsar JR, Yoder MC, Haneline LS, Ingram DA. Human CD341 AC1331VEGFR-21 cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 2007;35: 1109-1118.
25. Estes ML, Mund JA, Ingram DA, Case J. Identification of endothelial cells and progenitor cell subsets in human peripheral blood. Curr Protoc Cytom 2010;52:9.33.1-9.33.11.
26. Timmermans F, Van HF, De SM, Raedt R, Plasschaert F, De Buyzere ML, Gillebert TC, Plum J, Vandekerckhove B. Endothelial outgrowth cells are not derived from CD1331 cells or CD451 hematopoietic precursors. Arterioscler Thromb Vasc Biol 2007;27: 1572-1579.
27. Medina RJ, O'Neill CL, Sweeney M, Guduric-Fuchs J, Gardiner TA, Simpson DA, Stitt AW. Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med Genomics 2010;3:18.
28. Yoder MC. Defining human endothelial progenitor cells. J Thromb Haemost 2009;7: 49-52.
29. Timmermans F, Plum J, Yoder MC, Ingram DA, Vandekerckhove B, Case J. Endothelial progenitor cells: identity defined? J Cell Mol Med 2009;13: 87-102.
30. Richardson MR, Yoder MC. Endothelial progenitor cells: quo vadis? J Mol Cell Cardiol 2011;50: 266-272.
31. Ito H, Miyake M, Nishitani E, Mori K, Hatano T, Okuda T, Konoshima T, Takasaki M, Kozuka M, Mukainaka T, et al. Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima. Cancer Lett 1999;143: 5-13.
32. Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 2007;109: 4761-4768.
33. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003;9: 702-712.
34. Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol 2003;23: 1185-1189.
35. Yoder MC. Progenitor cells in the pulmonary circulation. Proc Am Thorac Soc 2011;8: 466-470.
36. Kotton DN, Fabian AJ, Mulligan RC. Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 2005;33: 328-334.
37. Chang JC, Summer R, Sun X, Fitzsimmons K, Fine A. Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol 2005;33: 335-342.
38. Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, Helisch A, SchaperW. Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res 2004;94: 230-238.
39. Perry TE, Song M, Despres DJ, Kim SM, San H, Yu ZX, Raghavachari N, Schnermann J, Cannon RO III, Orlic D. Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction. Cardiovasc Res 2009;84: 317-325.
40. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297: 2256-2259.
41. Hillebrands JL, Klatter FA, van Dijk WD, Rozing J. Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis. Nat Med 2002;8: 194-195.
42. Zhao YD, Ohkawara H, Rehman J, Wary KK, Vogel SM, Minshall RD, Zhao YY, Malik AB. Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated RAC1 and CDC42 signaling. Circ Res 2009;105: 696-704.
43. Zhao YD, Ohkawara H, Vogel SM, Malik AB, Zhao YY. Bone marrow- derived progenitor cells prevent thrombin-induced increase in lung vascular permeability. Am J Physiol Lung Cell Mol Physiol 2010;298:L36-L44.
44. Alvarez DF, Huang L, King JA, ElZarrad MK, Yoder MC, Stevens T. Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am J Physiol Lung Cell Mol Physiol 2008;294:L419-L430.
45. Schniedermann J, Rennecke M, Buttler K, Richter G, Stadtler AM, Norgall S, Badar M, Barleon B, May T, Wilting J, et al. Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels. BMC Cell Biol 2010;11:50.
46. Hemmen K, Reinl T, Buttler K, Behler F, Dieken H, Jansch L, Wilting J, Weich HA. High-resolution mass spectrometric analysis of the secretome from mouse lung endothelial progenitor cells. Angiogenesis 2011;14: 163-172.
47. Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med 2005; 172: 854-860.
48. Burnham EL, Mealer M, Gaydos J, Majka S, Moss M. Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol 2010;43: 326-333.
49. Qi Y, Qian L, Sun B, Chen C, Cao Y. Circulating CD34(1) cells are elevated in neonates with respiratory distress syndrome. Inflamm Res 2010;59: 889-895.
50. Suratt BT, Cool CD, Serls AE, Chen L, Varella-Garcia M, Shpall EJ, Brown KK, Worthen GS. Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2003; 168: 318-322.
51. Yamada M, Kubo H, Kobayashi S, Ishizawa K, Numasaki M, Ueda S, Suzuki T, Sasaki H. Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 2004;172: 1266-1272.
52. Lam CF, Liu YC, Hsu JK, Yeh PA, Su TY, Huang CC, Lin MW, Wu PC, Chang PJ, Tsai YC. Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits. Anesthesiology 2008;108: 392-401.
53. Lam CF, Roan JN, Lee CH, Chang PJ, Huang CC, Liu YC, Jiang MJ, Tsai YC. Transplantation of endothelial progenitor cells improves pulmonary endothelial function and gas exchange in rabbits with endotoxin-induced acute lung injury. Anesth Analg 2011;112: 620-627.
54. Rafat N, Dacho C, Kowanetz G, Krebs J, Tsagogiorgas C, Ghezel- Ahmadi V, Yard B, Beck G. Therapeutic effects of endothelial progenitor cells in LPS-induced acute respiratory dysfunction syndrome. Anasth Intensivmed 2012;4: 196-208.
55. Kahler CM, Wechselberger J, Hilbe W, Gschwendtner A, Colleselli D, Niederegger H, Boneberg EM, Spizzo G, Wendel A, Gunsilius E, et al. Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res 2007;8:50.
56. Mao M, Wang SN, Lv XJ, Wang Y, Xu JC. Intravenous delivery of bone marrow-derived endothelial progenitor cells improves survival and attenuates lipopolysaccharide-induced lung injury in rats. Shock 2010; 34: 196-204.
57. Wary KK, Vogel SM, Garrean S, Zhao YD, Malik AB. Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bonemarrow- derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice. Stem Cells 2009;27: 3112-3120.
58. Aicher A, Rentsch M, Sasaki K, Ellwart JW, Fandrich F, Siebert R, Cooke JP, Dimmeler S, Heeschen C. Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res 2007;100: 581-589.
59. Forbes S, Vig P, Poulsom R, Thomas H, Alison M. Hepatic stem cells. J Pathol 2002;197: 510-518.
60. Prater DN, Case J, Ingram DA, Yoder MC. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007;21: 1141-1149.
61. Povsic TJ, Zavodni KL, Vainorius E, Kherani JF, Goldschmidt-Clermont PJ, Peterson ED. Common endothelial progenitor cell assays identify discrete endothelial progenitor cell populations. Am Heart J 2009;157: 335-344.