MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion by controlling HIF-1 alpha expression in beating rabbit atria

Biochemical and Biophysical Research Communications

Volumn 438, Issue 3, 2013, Pages 507-512

  Zhang, Qiu li ^a,b   Cui, Bai ri ^a   Li, Hai yan ^a   Li, Ping ^a   Hong, Lan ^a   Liu, Li ping ^a   Ding, Da zhi ^a   Cui, Xun ^a  

^a YANBIAN UNIVERSITY   (China)

^b INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

Acute hypoxia; Atrial natriuretic peptide (ANP); Hypoxia inducible factor 1 (HIF 1); Mitogen activated protein kinase (MAPK); Phosphatidylinositol 3 kinase (PI3K)

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ATRIAL NATRIURETIC FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; ROTENONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HEART ATRIUM; HEART BEAT; HEART MUSCLE ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

ACUTE HYPOXIA; ATRIAL NATRIURETIC PEPTIDE (ANP); HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1); MITOGEN-ACTIVATED PROTEIN KINASE (MAPK); PHOSPHATIDYLINOSITOL 3-KINASE (PI3K);

ANIMALS; ANOXIA; ATRIAL NATRIURETIC FACTOR; CHROMONES; FEMALE; FLAVONOIDS; HEART ATRIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASE; RABBITS; SIGNAL TRANSDUCTION;

ORYCTOLAGUS CUNICULUS;

EID: 84882849919     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.106     Document Type: Article

References (25)

1. Lopez A.D., Mathers C.D., Ezzati M., Jamison D.T., Murray C.J. Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data. Lancet 2001, 367(2006):1747-1757.
2. Dobrucki L.W., Meoli D.F., Hu J., Sadeghi M.M., Sinusas A.J. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal of Physiology and Pharmacology 2009, 60(Suppl 4):117-123.
3. Kim D.K., Choi E., Song B.W., Cha M.J., Ham O., Lee S.Y., Lee C.Y., Park J.H., Song H., Hwang K.C. Differentially regulated functional gene clusters identified in early hypoxic cardiomyocytes. Molecular Biology Reports 2012, 39:9549-9556.
4. Semenza G.L. HIF-1 and human disease: one highly involved factor. Genes and Development 2000, 14:1983-1991.
5. Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. Journal of Biological Chemistry 1995, 270:1230-1237.
6. Jiang B.H., Rue E., Wang G.L., Roe R., Semenza G.L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. Journal of Biological Chemistry 1996, 271:17771-17778.
7. Hong L., Xi J., Zhang Y., Tian W., Xu J., Cui X., Xu Z. Atrial natriuretic peptide prevents the mitochondrial permeability transition pore opening by inactivating glycogen synthase kinase 3beta via PKG and PI3K in cardiac H9c2 cells. European Journal of Pharmacology 2012, 695:13-19.
8. Arjamaa O., Nikinmaa M. Hypoxia regulates the natriuretic peptide system. International Journal of Physiology, Pathophysiology and Pharmacology 2011, 3:191-201.
9. Chen Y.F. Atrial natriuretic peptide in hypoxia. Peptides 2005, 26:1068-1077.
10. Casals G., Ros J., Sionis A., Davidson M.M., Morales-Ruiz M., Jimenez W. Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes. American Journal of Physiology Heart and Circulatory Physiology 2009, 297:H550-5.
11. Roson M.I., Toblli J.E., Della P.S., Gorzalczany S., Pandolfo M., Cavallero S., Fernandez B.E. Renal protective role of atrial natriuretic peptide in acute sodium overload-induced inflammatory response. American Journal of Nephrology 2006, 26:590-601.
12. Chun Y.S., Hyun J.Y., Kwak Y.G., Kim I.S., Kim C.H., Choi E., Kim M.S., Park J.W. Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1. Biochemical Journal 2003, 370:149-157.
13. Agani F., Jiang B.H. Oxygen-independent regulation of HIF-1: novel involvement of PI3K/ AKT/mTOR pathway in cancer. Current Cancer Drug Targets 2013, 13:245-251.
14. Marzo F., Lavorgna A., Coluzzi G., Santucci E., Tarantino F., Rio T., Conti E., Autore C., Agati L., Andreotti F. Erythropoietin in heart and vessels: focus on transcription and signalling pathways. Journal of Thrombosis and Thrombolysis 2008, 26:183-187.
15. Belaiba R.S., Bonello S., Zahringer C., Schmidt S., Hess J., Kietzmann T., Gorlach A. Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. Molecular Biology of the Cell 2007, 18:4691-4697.
16. Kim C.H., Cho Y.S., Chun Y.S., Park J.W., Kim M.S. Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circulation Research 2002, 90:E25-33.
17. Tokudome T., Horio T., Yoshihara F., Suga S., Kawano Y., Kohno M., Kangawa K. Direct effects of high glucose and insulin on protein synthesis in cultured cardiac myocytes and DNA and collagen synthesis in cardiac fibroblasts. Metabolism 2004, 53:710-715.
18. Liu L.P., Hong L., Yu L., Li H.Y., Ding D.Z., Jin S.J., Cui X. Ouabain stimulates atrial natriuretic peptide secretion via the endothelin-1/ET(B) receptor-mediated pathway in beating rabbit atria. Life Sciences 2012, 90:793-798.
19. Cho K.W., Kim S.H., Hwang Y.H., Seul K.H. Extracellular fluid translocation in perfused rabbit atria: implication in control of atrial natriuretic peptide secretion. Journal of Physiology 1993, 468:591-607.
20. Semenza G.L. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 2009, 24:97-106.
21. Chen Y.F., Durand J., Claycomb W.C. Hypoxia stimulates atrial natriuretic peptide gene expression in cultured atrial cardiocytes. Hypertension 1997, 29:75-82.
22. Klement G.L., Goukassian D., Hlatky L., Carrozza J., Morgan J.P., Yan X. Cancer therapy targeting the HER2-PI3K pathway: potential impact on the heart. Front Pharmacology 2012, 3:113.
23. Orton R.J., Sturm O.E., Vyshemirsky V., Calder M., Gilbert D.R., Kolch W. Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochemical Journal 2005, 392:249-261.
24. Aoyagi T., Matsui T. Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Current Pharmaceutical Design 2011, 17:1818-1824.
25. Liu X., Wu X., Cai L., Tang C., Su J. Hypoxic preconditioning of cardiomyocytes and cardioprotection: phophorylation of HIF-1alpha induced by p42/p44 mitogen-activated protein kinases is involved. Pathophysiology 2003, 9:201-205.