Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 1004-1018

  Serafino, Annalucia ^a   Moroni, Noemi ^a   Psaila, Rossana ^a   Zonfrillo, Manuela ^a   Andreola, Federica ^a   Wannenes, Francesca ^a   Mercuri, Luana ^a   Rasi, Guido ^b   Pierimarchi, Pasquale ^a  

^a INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Akt; Colon adenocarcinoma cell; NHE 1 inhibition; Tumor microenvironmental pH; Wnt pathway

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA CATENIN; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; SERINE; UVOMORULIN; WNT PROTEIN;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; COLORECTAL CANCER; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOCARCINOMA; AMILORIDE; ANIMALS; ATRIAL NATRIURETIC FACTOR; BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SODIUM-HYDROGEN ANTIPORTER; WNT SIGNALING PATHWAY;

RATTUS;

EID: 84859027559     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.02.016     Document Type: Article

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