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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 4048-4052

Molecular determinants for improved activity at PPARα: Structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα

(5) Lamers, Christina a Dittrich, Michaela a Steri, Ramona a Proschak, Ewgenij a Schubert Zsilavecz, Manfred a

a GOETHE UNIVERSITY (Germany)

Author keywords

Dual PPAR agonist; Metabolic syndrome; Peroxisome proliferator activated receptor; Site directed mutagenesis; Structure activity relationship

Indexed keywords

2 ((4 CHLORO 6 ((4 (PHENYLAMINO)PHENYL)AMINO)PYRIMIDIN 2 YL)THIO)OCTANOICACID; DIPHENYLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PIRINIXIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WATER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRIMIDINE DERIVATIVE;

ARTICLE; COMPUTER MODEL; DRUG DESIGN; DRUG INTERACTION; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR DOCKING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION ASSAY; VALIDATION STUDY; AGONISTS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; HUMAN; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PPAR ALPHA; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905900793 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.05.058 Document Type: Article

Times cited : (7)

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