α-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma

Archiv der Pharmazie

Volumn 341, Issue 3, 2008, Pages 191-195

  Rau, Oliver ^a   Syha, Yvonne ^a   Zettl, Heiko ^a   Kock, Michael ^b   Bock, Andreas ^b   Schubert Zsilavecz, Manfred ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Phenion GmbH and Co   (Germany)

Author keywords

dual agonist; Peroxisome proliferator activated receptor; Pirinixic acid; PPAR

Indexed keywords

2 [4 CHLORO 6 (2,3 DIMETHYLPHENYLAMINO)PYRIMIDIN 2 YLSULFANYL] 2 METHYLPROPIONIC ACID; 2 [4 CHLORO 6 (2,3 DIMETHYLPHENYLAMINO)PYRIMIDIN 2 YLSULFANYL]HEXANOIC ACID; 2 [4 CHLORO 6 (2,3 DIMETHYLPHENYLAMINO)PYRIMIDIN 2 YLSULFANYL]OCTANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PIRINIXIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; LUCIFERASE; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENERGY BALANCE; HUMAN; HYPERLIPIDEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; REACTION ANALYSIS; RECEPTOR UPREGULATION; SUBSTITUTION REACTION; COMPARATIVE STUDY; DRUG POTENTIATION; GENETICS; IN VITRO STUDY; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMANS; LUCIFERASES; PEROXISOME PROLIFERATORS; PPAR ALPHA; PPAR GAMMA; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 44649181077     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700209     Document Type: Article

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