Novel pirinixic acids as PPARα preferential dual PPARα/ γ agonists

QSAR and Combinatorial Science

Volumn 28, Issue 5, 2009, Pages 576-586

  Zettl, Heiko ^a   Dittrich, Michaela ^a   Steri, Ramona ^a   Proschak, Ewgenij ^a   Rau, Oliver ^a   Steinhilber, Dieter ^a   Schneider, Gisbert ^a   Lämmerhofer, Michael ^b   Schubert Zsilavecz, Manfred ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chirality; Drug design; Medicinal chemistry; Molecular modeling; PPAR; Structure activity relationships

Indexed keywords

CHIRALITY; CYTOLOGY; ORGANIC ACIDS; SCAFFOLDS; STEREOCHEMISTRY;

ALKYL SUBSTITUTION; DOCKING STUDIES; DRUG DESIGN; LIGAND BINDING; MEDICINAL CHEMISTRY; NANOMOLAR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; RECEPTOR ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS; SUBSTITUTION PATTERNS;

ENANTIOMERS;

2 [4 (BIPHENYL 4 YLAMINO) 6 CHLOROPYRIMIDIN 2 YLTHIO]OCTANOIC ACID; 2 [4 (BIPHENYL 4 YLMETHYLAMINO) 6 CHLOROPYRIMIDIN 2 YLTHIO]OCTANOIC ACID; 2 [4 CHLORO 6 (2 PHENOXYETHYLAMINO)PYRIMIDIN 2 YLTHIO]ACETIC ACID; 2 [4 CHLORO 6 (2 PHENOXYETHYLAMINO)PYRIMIDIN 2 YLTHIO]OCTANOIC ACID; 2 [4 CHLORO 6 (4' CYANOBIPHENYL 4 YLAMINO)PYRIMIDIN 2 YLTHIO]OCTANOIC ACID; 2 [4 CHLORO 6 (5 METHOXY 2 METHYLBIPHENYL 4 YLAMINO) PYRIMIDIN 2 YLTHIO]OCTANOIC ACID; 2 [4 CHLORO 6 (PHENETHYLAMINO)PYRIMIDIN 2 YLTHIO]ACETIC ACID; 2 [4 CHLORO 6 (PHENETHYLAMINO)PYRIMIDIN 2 YLTHIO]OCTANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PIRINIXIC ACID; PIRINIXIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR UPREGULATION; STEREOCHEMISTRY;

EID: 67649222525     PISSN: 1611020X     EISSN: 16110218     Source Type: Journal    
DOI: 10.1002/qsar.200860163     Document Type: Article

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