Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells

Gene Therapy

Volumn 21, Issue 8, 2014, Pages 715-722

  Flores, R R ^a   Zhou, L ^a   Robbins, P D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL; C57BL MOUSE; DEPENDOPARVOVIRUS; DIABETES MELLITUS, TYPE 1; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; LYMPH NODE; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; REGULATORY T LYMPHOCYTE;

ANIMALS; DEPENDOVIRUS; DIABETES MELLITUS, TYPE 1; FORKHEAD TRANSCRIPTION FACTORS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; INSULIN-SECRETING CELLS; INTERLEUKIN-2; INTERLEUKIN-4; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; T-LYMPHOCYTES, REGULATORY;

EID: 84905899333     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2014.45     Document Type: Article

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