Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

World Journal of Gastroenterology

Volumn , Issue 29, 2014, Pages 9862-9871

  Jeong, Woo Jeong ^a   Cha, Pu Hyeon ^a   Choi, Kang Yell ^a  

^a Yonsei University   (South Korea)

Author keywords

Colorectal cancer; Combinational therapy; Epidermal growth factor receptor; K ras mutation; Resistance

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BGT226; CETUXIMAB; COBIMETINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PILARALISIB; PIMASERTIB; PROTEIN KINASE B; RAS PROTEIN; RDEA119; RO5126766; SELUMETINIB; SORAFENIB; TAK 733; TRAMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEMURAFENIB; XL 281; XL 765; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN INHIBITOR; RAF PROTEIN; RAS PROTEIN INHIBITOR; EGFR PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR;

CANCER CHEMOTHERAPY; CANCER RESISTANCE; DRUG EFFICACY; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; METASTATIC COLORECTAL CANCER; NONHUMAN; ONCOGENE K RAS; ONCOGENE N RAS; PHASE 3 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIGNAL TRANSDUCTION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; GENETIC VARIABILITY; ANIMAL; ANTAGONISTS AND INHIBITORS; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; METASTASIS; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84905866650     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i29.9862     Document Type: Review

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