-
2
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network
-
Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487:330-337. Cancer Genome Atlas Network.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
3
-
-
84890237993
-
Association of colorectal cancer intrinsic subtypes with prognosis, chemotherapy response, deficient mismatch repair, and epithelial to mesenchymal transition (EMT): Proc ASCO GI meeting
-
abstr 333
-
Simon I., Roepman P., Schlicker A., et al. Association of colorectal cancer intrinsic subtypes with prognosis, chemotherapy response, deficient mismatch repair, and epithelial to mesenchymal transition (EMT): Proc ASCO GI meeting. JClin Oncol 2013, (Suppl 34). abstr 333.
-
(2013)
JClin Oncol
, Issue.34 SUPPL
-
-
Simon, I.1
Roepman, P.2
Schlicker, A.3
-
4
-
-
79959357339
-
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
-
Kelley R.K., Venook A.P. Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?. Clin Colorectal Cancer 2011, 10:73-80.
-
(2011)
Clin Colorectal Cancer
, vol.10
, pp. 73-80
-
-
Kelley, R.K.1
Venook, A.P.2
-
6
-
-
79851511414
-
Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field
-
Ogino S., Chan A.T., Fuchs C.S., et al. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2010, 60:397-411.
-
(2010)
Gut
, vol.60
, pp. 397-411
-
-
Ogino, S.1
Chan, A.T.2
Fuchs, C.S.3
-
7
-
-
79954435158
-
Colorectal cancer epigenetics: complex simplicity
-
van Engeland M., Derks S., Smits K.M., et al. Colorectal cancer epigenetics: complex simplicity. JClin Oncol 2011, 29:1382-1391.
-
(2011)
JClin Oncol
, vol.29
, pp. 1382-1391
-
-
van Engeland, M.1
Derks, S.2
Smits, K.M.3
-
8
-
-
84860589077
-
Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
-
Yamauchi M., Morikawa T., Kuchiba A., et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012, 61:847-854.
-
(2012)
Gut
, vol.61
, pp. 847-854
-
-
Yamauchi, M.1
Morikawa, T.2
Kuchiba, A.3
-
9
-
-
60249083789
-
Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer: potential implications for the surgical oncologist
-
Soreide K., Nedrebo B.S., Knapp J.C., et al. Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer: potential implications for the surgical oncologist. Surg Oncol 2009, 18:31-50.
-
(2009)
Surg Oncol
, vol.18
, pp. 31-50
-
-
Soreide, K.1
Nedrebo, B.S.2
Knapp, J.C.3
-
10
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E., Kohne C.H., Hitre E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. NEngl J Med 2009, 360:1408-1417.
-
(2009)
NEngl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
11
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
-
Douillard J.Y., Siena S., Cassidy J., et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. JClin Oncol 2010, 28:4697-4705.
-
(2010)
JClin Oncol
, vol.28
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
12
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
Jonker D.J., O'Callaghan C.J., Karapetis C.S., et al. Cetuximab for the treatment of colorectal cancer. NEngl J Med 2007, 357:2040-2048.
-
(2007)
NEngl J Med
, vol.357
, pp. 2040-2048
-
-
Jonker, D.J.1
O'Callaghan, C.J.2
Karapetis, C.S.3
-
13
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. JClin Oncol 2007, 25:1658-1664.
-
(2007)
JClin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
14
-
-
44249111440
-
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero A.F., Maurel J., Fehrenbacher L., et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. JClin Oncol 2008, 26:2311-2319.
-
(2008)
JClin Oncol
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
-
15
-
-
78149239651
-
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
-
Peeters M., Price T.J., Cervantes A., et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. JClin Oncol 2010, 28:4706-4713.
-
(2010)
JClin Oncol
, vol.28
, pp. 4706-4713
-
-
Peeters, M.1
Price, T.J.2
Cervantes, A.3
-
16
-
-
77949435827
-
Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
-
Bardelli A., Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. JClin Oncol 2010, 28:1254-1261.
-
(2010)
JClin Oncol
, vol.28
, pp. 1254-1261
-
-
Bardelli, A.1
Siena, S.2
-
17
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. JClin Oncol 2008, 26:1626-1634.
-
(2008)
JClin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
18
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A., Bachet J.B., Le Corre D., et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006, 66:3992-3995.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
19
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
-
Di Fiore F., Blanchard F., Charbonnier F., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br J Cancer 2007, 96:1166-1169.
-
(2007)
Br J Cancer
, vol.96
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
-
20
-
-
79957523828
-
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer
-
De Roock W., De Vriendt V., Normanno N., et al. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011, 12:594-603.
-
(2011)
Lancet Oncol
, vol.12
, pp. 594-603
-
-
De Roock, W.1
De Vriendt, V.2
Normanno, N.3
-
21
-
-
79960149283
-
Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer
-
Price T.J., Hardingham J.E., Lee C.K., et al. Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer. JClin Oncol 2011, 29:2675-2682.
-
(2011)
JClin Oncol
, vol.29
, pp. 2675-2682
-
-
Price, T.J.1
Hardingham, J.E.2
Lee, C.K.3
-
22
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
-
De Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2011, 11:753-762.
-
(2011)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
-
23
-
-
77956625930
-
Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009
-
Van Cutsem E., Dicato M., Arber N., et al. Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009. Ann Oncol 2010, 21(Suppl 6):vi1-vi10.
-
(2010)
Ann Oncol
, vol.21
, Issue.6 SUPPL
-
-
Van Cutsem, E.1
Dicato, M.2
Arber, N.3
-
24
-
-
34447285021
-
UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan
-
Stewart C.F., Panetta J.C., O'Shaughnessy M.A., et al. UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan. JClin Oncol 2007, 25:2594-2600.
-
(2007)
JClin Oncol
, vol.25
, pp. 2594-2600
-
-
Stewart, C.F.1
Panetta, J.C.2
O'Shaughnessy, M.A.3
-
25
-
-
66849111193
-
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
-
Innocenti F., Kroetz D.L., Schuetz E., et al. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. JClin Oncol 2009, 27:2604-2614.
-
(2009)
JClin Oncol
, vol.27
, pp. 2604-2614
-
-
Innocenti, F.1
Kroetz, D.L.2
Schuetz, E.3
-
26
-
-
79251513942
-
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer
-
Kelley R.K., Van Bebber S.L., Phillips K.A., et al. Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer. JNatl Compr Canc Netw 2011, 9:13-25.
-
(2011)
JNatl Compr Canc Netw
, vol.9
, pp. 13-25
-
-
Kelley, R.K.1
Van Bebber, S.L.2
Phillips, K.A.3
-
27
-
-
64649092523
-
Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?
-
Adam R., Wicherts D.A., de Haas R.J., et al. Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?. JClin Oncol 2009, 27:1829-1835.
-
(2009)
JClin Oncol
, vol.27
, pp. 1829-1835
-
-
Adam, R.1
Wicherts, D.A.2
de Haas, R.J.3
-
28
-
-
73249130298
-
Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial
-
Folprecht G., Gruenberger T., Bechstein W.O., et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol 2010, 11:38-47.
-
(2010)
Lancet Oncol
, vol.11
, pp. 38-47
-
-
Folprecht, G.1
Gruenberger, T.2
Bechstein, W.O.3
-
29
-
-
79959947067
-
Amulticentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for upfront resection
-
Wong R., Cunningham D., Barbachano Y., et al. Amulticentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for upfront resection. Ann Oncol 2010, 22:2042-2048.
-
(2010)
Ann Oncol
, vol.22
, pp. 2042-2048
-
-
Wong, R.1
Cunningham, D.2
Barbachano, Y.3
-
30
-
-
84880736194
-
Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases
-
Ye L.C., Liu T.S., Ren L., et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. JClin Oncol 2013, 31:1931-1938.
-
(2013)
JClin Oncol
, vol.31
, pp. 1931-1938
-
-
Ye, L.C.1
Liu, T.S.2
Ren, L.3
-
31
-
-
84890153174
-
-
Springer, New York, S.G. Edge, D.R. Byrd, C.C. Compton (Eds.)
-
Colon and rectum 2010, 173-260. Springer, New York. 7th ed. S.G. Edge, D.R. Byrd, C.C. Compton (Eds.).
-
(2010)
Colon and rectum
, pp. 173-260
-
-
-
32
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H.F., Novotny L., Cartwright W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. NEngl J Med 2004, 350:2335-2342.
-
(2004)
NEngl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.F.1
Novotny, L.2
Cartwright, W.3
-
33
-
-
84866152751
-
Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: results of a randomized phase III intergroup study (TML study)-Proc ASCO Annual Meeting
-
Arnold D., Bennouna J., Sastre J., et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: results of a randomized phase III intergroup study (TML study)-Proc ASCO Annual Meeting. JClin Oncol 2012, 30(18 Suppl).
-
(2012)
JClin Oncol
, vol.30
, Issue.18 SUPPL
-
-
Arnold, D.1
Bennouna, J.2
Sastre, J.3
-
34
-
-
84871667344
-
Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients (pts) with metastatic colorectal cancer (mCRC): efficacy and safety results of the International GERCOR DREAM phase III trial-Proc ASCO Annual Meeting
-
Tournigand C., Scheithauer W., Lledo G., et al. Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in patients (pts) with metastatic colorectal cancer (mCRC): efficacy and safety results of the International GERCOR DREAM phase III trial-Proc ASCO Annual Meeting. JClin Oncol 2012, 30(18 Suppl).
-
(2012)
JClin Oncol
, vol.30
, Issue.18 SUPPL
-
-
Tournigand, C.1
Scheithauer, W.2
Lledo, G.3
-
35
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E., Tabernero J., Lakomy R., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. JClin Oncol 2013, 30:3499-3506.
-
(2013)
JClin Oncol
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
36
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A., Van Cutsem E., Sobrero A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2012, 381:303-312.
-
(2012)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
37
-
-
34948846004
-
Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? the need for high quality pathology
-
Morris E.J., Maughan N.J., Forman D., et al. Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? the need for high quality pathology. Gut 2007, 56:1419-1425.
-
(2007)
Gut
, vol.56
, pp. 1419-1425
-
-
Morris, E.J.1
Maughan, N.J.2
Forman, D.3
-
38
-
-
0041885405
-
Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
-
Le Voyer T.E., Sigurdson E.R., Hanlon A.L., et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. JClin Oncol 2003, 21:2912-2919.
-
(2003)
JClin Oncol
, vol.21
, pp. 2912-2919
-
-
Le Voyer, T.E.1
Sigurdson, E.R.2
Hanlon, A.L.3
-
39
-
-
77954748953
-
Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
-
Sargent D.J., Marsoni S., Monges G., et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. JClin Oncol 2010, 28:3219-3226.
-
(2010)
JClin Oncol
, vol.28
, pp. 3219-3226
-
-
Sargent, D.J.1
Marsoni, S.2
Monges, G.3
-
40
-
-
79953856354
-
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
-
Hutchins G., Southward K., Handley K., et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. JClin Oncol 2012, 29:1261-1270.
-
(2012)
JClin Oncol
, vol.29
, pp. 1261-1270
-
-
Hutchins, G.1
Southward, K.2
Handley, K.3
-
41
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M., Rowan A.J., Horswell S., et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. NEngl J Med 2012, 366:883-892.
-
(2012)
NEngl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
|