Docosahexaenoic acid and periodontitis in adults: A randomized controlled trial

Journal of Dental Research

Volumn 93, Issue 8, 2014, Pages 767-773

  Naqvi, A Z ^a,b   Hasturk, H ^c   Mu, L ^a   Phillips, R S ^a,b   Davis, R B ^a,d   Halem, S ^c,e   Campos, H ^d   Goodson, J M ^c   Van Dyke, T E ^c   Mukamal, K J ^a,d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FORSYTH INSTITUTE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e Dentists Collaborative   (United States)

Author keywords

clinical study; DHA; fatty acid; gingivitis; inflammation; omega 3

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; AUTACOID; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; IL6 PROTEIN, HUMAN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ADULT; BLOOD; CELL MEMBRANE; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; FEMALE; FOLLOW UP; GINGIVITIS; HUMAN; MALE; MIDDLE AGED; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PLAQUE INDEX; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; C-REACTIVE PROTEIN; CELL MEMBRANE; DENTAL PLAQUE INDEX; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; ERYTHROCYTES; FEMALE; FOLLOW-UP STUDIES; GINGIVAL CREVICULAR FLUID; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MIDDLE AGED; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PLACEBOS; TREATMENT OUTCOME;

EID: 84905843091     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034514541125     Document Type: Article

References (25)

1. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999 ; 4: 1-6
2. Browne RW, Kantarci A, LaMonte MJ, Andrews CA, Hovey KM, Falkner KL, et al. Performance of multiplex cytokine assays in serum and saliva among community-dwelling postmenopausal women. PLoS One. 2013 ; 8: e59498
3. Campan P, Planchand PO, Duran D. Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. J Clin Periodontol. 1997 ; 24: 907-913
4. Eberhard J, Heilmann F, Acil Y, Albers HK, Jepsen S. Local application of n-3 or n-6 polyunsaturated fatty acids in the treatment of human experimental gingivitis. J Clin Periodontol. 2002 ; 29: 364-369
5. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012 ; 91: 914-920
6. El-Sharkawy H, Aboelsaad N, Eliwa M, Darweesh M, Alshahat M, Kantarci A, et al. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 fatty acids and low-dose aspirin. J Periodontol. 2010 ; 81: 1635-1643
7. Elkhouli AM. The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). J Periodontal Res. 2011 ; 46: 261-268
8. Faizuddin M, Tarannum F, Korla N, Swamy S. Association between long-term aspirin use and periodontal attachment level in humans: a cross-sectional investigation. Aust Dent J. 2012 ; 57: 45-50
9. Genco RJ, Falkner KL, Grossi S, Dunford R, Trevisan M. Validity of self-reported measures for surveillance of periodontal disease in two western New York population-based studies. J Periodontol. 2007 ; 78 (7). 1439S - 1454S
10. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009 ; 42: 377-381
11. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, et al. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J. 2006 ; 20: 401-403
12. Iwasaki M, Yoshihara A, Moynihan P, Watanabe R, Taylor GW, Miyazaki H. Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease. Nutrition. 2010 ; 26: 1105-1109
13. Jain A, Batista EL, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003 ; 71: 6012-6018
14. Kabir-ud-Din, Rub MA, Naqvi AZ. Micellization of mixtures of amphiphilic drugs and cationic surfactants: a detailed study. Colloids Surf B Biointerfaces. 2012 ; 92: 16-24
15. Lehner T, Wilton JM, Challacombe SJ, Ivanyi L. Sequential cell-mediated immune responses in experimental gingivitis in man. Clin Exp Immunol. 1974 ; 16: 481-492
16. Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol. 2007 ; 178: 496-502
17. Naqvi AZ, Buettner C, Phillips RS, Davis RB, Mukamal KJ. n-3 fatty acids and periodontitis in US adults. J Am Diet Assoc. 2010 ; 110: 1669-1675
18. Rosenstein ED, Kushner LJ, Kramer N, Kazandjian G. Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis. Prostaglandins Leukot Essent Fatty Acids. 2003 ; 68: 213-218
19. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005 ; 6: 1191-1197
20. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 ; 171: 6856-6865
21. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008 ; 8: 349-361
22. Silness J, Loe H. Periodontal disease in pregnancy: II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand. 1964 ; 22: 121-135
23. Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010 ; 107: 1170-1184
24. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, et al. Resolvin D1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 ; 282: 9323-9334
25. Zhao G, Etherton TD, Martin KR, Gillies PJ, West SG, Kris-Etherton PM. Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am J Clin Nutr. 2007 ; 85: 385-391