Local application of n-3 or n-6 polyunsaturated fatty acids in the treatment of human experimental gingivitis

Journal of Clinical Periodontology

Volumn 29, Issue 4, 2002, Pages 364-369

  Eberhard, Jörg ^a,b   Heilmann, Frederik ^a   Açil, Yahya ^b   Albers, Hans Karl ^a   Jepsen, Soren ^a  

^a Department of Operative Dentistry and Periodontology ^*  (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Clinical trial; Experimental gingivitis; Leukotrienes; Polyunsaturated fatty acids

Indexed keywords

FISH OIL; LEUKOTRIENE B4; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; TRIACYLGLYCEROL; UNSATURATED FATTY ACID;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CASE CONTROL STUDY; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GINGIVA BLEEDING; GINGIVITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; METABOLISM; MOUTH HYGIENE; NONPARAMETRIC TEST; NORMAL DISTRIBUTION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; FEMALE; FISH OILS; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; GINGIVITIS; HUMANS; LEUKOTRIENE B4; MALE; MATCHED-PAIR ANALYSIS; MOUTHWASHES; NORMAL DISTRIBUTION; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES;

EID: 0036548783     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051X.2002.290413.x     Document Type: Article

References (30)

1. Asian, A. & Triadafilopoulos, G. (1992) Fish oil fatty acid supplementation in ulcerative colitis: a double-blind, placebo-controlled, crossover study. American Journal of Gastroenterology 87, 432-437.
2. Campan, P., Planchand, P. O. & Duran, D. (1997) Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. Journal of Clinical Periodontology 24, 907-913.
3. Chen, L. Y., Lawson, D. L. & Mehta, J. L. (1994) Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. Thrombosis Research 76, 317-322.
4. Croft, K. D., Codde, J. P., Barden, A., Vandongen, R. & Beilin, L. J. (1988) Effect of dietary fish oils on the formation of leukotriene B4 and B5, thromboxane and platelet activating factor by rat leukocytes. Clinical and Experimental Pharmacology and Physiology 15, 517-525.
5. Dewsbury, C. C., Graham, P. & Darley, C. R. (1989) Topical eicosanpentaenoic acid (EPA) in the treatment of psoriasis. British Journal of Dermatology 120, 581-584.
6. Eberhard, J., Jepsen, S., Albers, H. K. & Acil, Y. (2000) Quantification of arachidonic acids metabolites in inflamed gingival tissues. Analytical Biochemistry 280, 258-263.
7. ElAttar, T. M., Lin, H. S. & Platt, R. D. (1990) Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis (II). Fibroblasts. Prostaglandins Leukotrienes Essential Fatty Acids 39, 135-139.
8. Fletcher, M. P. & Ziboh, V. A. (1990) Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipide fatty acid composition and activation response. Inflammation 14, 585-597.
9. Ford-Hutchinson, A., Bray, M., Cunningham, F., Davidson, E. & Smith, M. (1980) Leukotriene B4, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286, 264-265.
10. Heasman, P. A., Collins, J. G. & Offenbacher, S. (1993) Changes in crevicular fluid levels of interleukin-1beta, leukotriene B4, prostaglandin E2, thromboxane B2, and tumor necrosis factor alpha in experimental gingivitis. Journal of Clinical Periodontology 28, 241-247.
11. Iversen, L., Fogh, K., Bojesen, G. & Kragballe, K. (1991) Linoleic acid and dihomogammalenolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils invitro. Evidence of formation of anti-inflammatory compounds. Agents Actions 33, 286-291.
12. Iversen, L., Fogh, K. & Kragballe, K. (1992) Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: selective inhibition of the 5-lipoxygenase pathway. Archives of Dermatology Research 284, 222-226.
13. Johnson, T. C., Reinhardt, R. A., Payne, J. B., Dyer, J. K. & Patil, K. D. (1997) Experimental gingivitis in periodontitis-susceptible subjects. Journal of Clinical Periodontology 24, 618-625.
14. Kragballe, K., Voorhees, J. J. & Goetzl, E. (1987) Inhibition by leukotriene B5 of leukotriene B4-induced activation of human keratinocytes and neutrophils. Journal of Investigative Dermatology 88, 555-558.
15. Kragballe, K. & Fogh, K. (1989) A low-fat diet supplemented with dietary fish oil results in the improvement of psoriasis and in formation of leukotriene B5. Acta Dermatology and Venerology 69, 23-28.
16. Lee, T. T., Arm, J. J., Horton, C. C., Crea, A. A., Mencia-Huerta, J. M. & Spur, B. W. (1991) Effects of dietary fish oil lipids on allergic and inflammatory diseases. Allergy Proceedings 12, 299-303.
17. Lokesh, B. R., Black, J. M., German, J. B. & Kinsella, J. E. (1988) Docosahexaenoic acid and other dietary polyunsaturated fatty acids suppress leukotriene synthesis by mouse peritoneal macrophages. Lipids 23, 968-972.
18. Miller, C., Yamaguchi, R. Y. & Ziboh, V. A. (1989) Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. Lipids 24, 998-1003.
19. Mooney, M. A., Vaughn, D. M., Reinhart, G. A., Powers, R. D., Wright, J. C., Hoffman, C. E., Swaim, S. F. & Baker, H. J. (1998) Evaluation of the effects of omega-3 fatty acid-containing diets on the inflammatory stage of wound healing in dogs. American Journal of Veterinary Research 59, 859-863.
20. Nakamura, N., Hamazaki, T., Kobayashi, M. & Yazawa, K. (1994) The effect of oral administration of eicosapentaenoic and docosahexaenoic acids on acute inflam-mation and fatty acid composition in rats. Journal of Nutritional Science and Vitamins 40, 161-170.
21. Palmer, P. & Yeates, D. (1981) Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. British Journal of Pharmacology 73, 260-261.
22. Prescott, S. M., Zimerman, G. A. & Morrison, A. R. (1985) The effects of a diet rich in fish oil on human neutrophils: identification of leukotriene B5 as a metabolite. Prostaglandins 30, 209-27.
23. Sarpotdar, P. P. & Zatz, J. L. (1986) Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro. Journal of Pharmacological Science 75, 176-181.
24. Serhan, C., Rodin, A., Smolen, K., Samuelsson, B. & Weissmann, G. (1982) Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochemical and Biophysical Research Communication 107, 1006-1012.
25. Soyland, E., Funk, J., Rajka, G., Sandberg, M., Thune, P., Rustad, L., Helland, S., Middelfart, K., Odu, S., Falk, E., Solvoll, K., Bjorneboe, G.-E. & Drevon, C. (1993). Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. New England Journal of Medcine 24, 1812-1816.
26. Tanojo, H., Boelsma, E., Junginger, H. E., Ponec, M. & Boddé, H. E. (1997) In vivo human skin barrier modulation by topical application of fatty acids. Skin Pharmacology and Applied Skin Physiology 11, 87-97.
27. Ternowitz, T., Herlin, T. & Fogh, K. (1987) Human monocyte and polymorphonuclear leukocyte chemotaxis and chemokinetic response to leukotriene B4 and FMLP. Acta Pathology Microbiology Immunology 95, 47-54.
28. Tsai, C. C., Hong, Y. C., Chen, C. C. & Wu, Y. M. (1998) Measurement of prostaglandin E2 and leukotriene B4 in the gingival crevicular fluid. Journal of Dentistry 26, 97-103.
29. Zhao, H., Richards-Smith, B., Baer, A. N. & Green, F. A. (1995) Lipoxygenase mRNA in cultured human epidermal and oral keratinocytes. Journal of Lipid Research 33, 2444-2449.
30. Ziboh, V. A. (1999) Cutaneous essential fatty acids and hydroxy fatty acids: Modulation of inflammatory and hyperproliferative processes. In: Fatty acids and inflammatory skin diseases., pp. 55-7, Basel: Birkhaeuser Verlag.