A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

DMM Disease Models and Mechanisms

Volumn 7, Issue 8, 2014, Pages 963-976

  Sievert, Henning ^a   Pällmann, Nora ^a,b   Miller, Katharine K ^a   Hermans Borgmeyer, Irm ^a   Venz, Simone ^c   Sendoel, Ataman ^d,e   Preukschas, Michael ^a   Schweizer, Michaela ^a   Boettcher, Steffen ^e   Janiesch, P Christoph ^a   Streichert, Thomas ^f   Walther, Reinhard ^c   Hengartner, Michael O ^d   Manz, Markus G ^e   Brümmendorf, Tim H ^g   Bokemeyer, Carsten ^a   Braig, Melanie ^a   Hauber, Joachim ^b   Duncan, Kent E ^a   Balabanov, Stefan ^a,e  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^g UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Cancer; Hypusine modification; Mouse models; Translational control

Indexed keywords

DEOXYHYPUSINE HYDROXYLASE; DEOXYHYPUSINE SYNTHASE; HYPUSINE; INITIATION FACTOR; INITIATION FACTOR 5A; LYSINE; MIXED FUNCTION OXIDASE; MYC PROTEIN; OXIDOREDUCTASE; RAS PROTEIN; RNA BINDING PROTEIN;

3T3 CELL LINE; ALLELE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CAENORHABDITIS ELEGANS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION; DISEASE MODEL; EMBRYO DEATH; EMBRYO DEVELOPMENT; FIBROBLAST; GENE INACTIVATION; HYDROXYLATION; METABOLISM; MOUSE; PATHOLOGY; PHENOTYPE; PROTEIN SYNTHESIS;

3T3 CELLS; ALLELES; ANIMALS; CAENORHABDITIS ELEGANS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; FIBROBLASTS; GENE KNOCKOUT TECHNIQUES; HYDROXYLATION; LYSINE; MICE; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PEPTIDE INITIATION FACTORS; PHENOTYPE; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; RNA-BINDING PROTEINS;

EID: 84905816669     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.014449     Document Type: Article

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