Differential activation of intracellular versus plasmalemmal CB2 Cannabinoid receptors

Biochemistry

Volumn 53, Issue 30, 2014, Pages 4990-4999

  Brailoiu, G Cristina ^a   Deliu, Elena ^b   Marcu, Jahan ^b   Hoffman, Nicholas E ^b   Console Bram, Linda ^b   Zhao, Pingwei ^b   Madesh, Muniswamy ^b   Abood, Mary E ^b   Brailoiu, Eugen ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMICAL ACTIVATION;

2-ARACHIDONOYL GLYCEROLS; ACTIVATION RELEASE; BENEFICIAL EFFECTS; CANNABINOID RECEPTORS; DIFFERENTIAL SIGNALING; RECEPTOR LOCALIZATION; SUBCELLULAR LOCATION; THERAPEUTIC TARGETS;

ENZYME ACTIVITY;

BENZOXAZINES; CALCIUM SIGNALING; CELL LINE; HUMANS; INTRACELLULAR MEMBRANES; MOLECULAR SEQUENCE DATA; MORPHOLINES; NAPHTHALENES; RECEPTOR, CANNABINOID, CB2;

EID: 84905706935     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500632a     Document Type: Article

References (41)

1. 2 Pharmacol. Rev. 62, 588-5631
2. Anand, P., Whiteside, G., Fowler, C. J., and Hohmann, A. G. (2009) Targeting CB2 receptors and the endocannabinoid system for the treatment of pain Brain Res. Rev. 60, 255-266
3. Cabral, G. A. and Griffin-Thomas, L. (2009) Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation Expert Rev. Mol. Med. 11, e3
4. Riether, D. (2012) Selective cannabinoid receptor 2 modulators: A patent review 2009-present Expert Opin. Ther. Pat. 22, 495-510
5. Ruhl, T., Deuther-Conrad, W., Fischer, S., Gunther, R., Hennig, L., Krautscheid, H., and Brust, P. (2012) Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: Synthesis, radiolabelling, molecular modelling and biological evaluation Org. Med. Chem. Lett. 2, 32
6. Atwood, B. K. and Mackie, K. (2010) CB2: A cannabinoid receptor with an identity crisis Br. J. Pharmacol. 160, 467-479
7. 2 ligands Mol. Pharmacol. 81, 250-263
8. Onaivi, E. S., Ishiguro, H., Gu, S., and Liu, Q. R. (2012) CNS effects of CB2 cannabinoid receptors: Beyond neuro-immuno-cannabinoid activity J. Psychopharmacol. 26, 92-103
9. Liu, Q. R., Pan, C. H., Hishimoto, A., Li, C. Y., Xi, Z. X., Llorente-Berzal, A., Viveros, M. P., Ishiguro, H., Arinami, T., Onaivi, E. S., and Uhl, G. R. (2009) Species differences in cannabinoid receptor 2 (CNR2 gene): Identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands Genes Brain Behav. 8, 519-530
10. Bingham, B., Jones, P. G., Uveges, A. J., Kotnis, S., Lu, P., Smith, V. A., Sun, S. C., Resnick, L., Chlenov, M., He, Y., Strassle, B. W., Cummons, T. A., Piesla, M. J., Harrison, J. E., Whiteside, G. T., and Kennedy, J. D. (2007) Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers Br. J. Pharmacol. 151, 1061-1070
11. Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M., and Mailman, R. B. (2007) Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320, 1-13
12. den Boon, F. S., Chameau, P., Schaafsma-Zhao, Q., van Aken, W., Bari, M., Oddi, S., Kruse, C. G., Maccarrone, M., Wadman, W. J., and Werkman, T. R. (2012) Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors Proc. Natl. Acad. Sci. U.S.A. 109, 3534-3539
13. De Petrocellis, L., Marini, P., Matias, I., Moriello, A. S., Starowicz, K., Cristino, L., Nigam, S., and Di Marzo, V. (2007) Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma β-cells Exp. Cell Res. 313, 2993-3004
14. Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakane, S., Kodaka, T., Suhara, Y., Takayama, H., and Waku, K. (2000) Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells J. Biol. Chem. 275, 605-612
15. 2+ signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells Br. J. Pharmacol. 140, 1351-1362
16. Yu, J., Deliu, E., Zhang, X. Q., Hoffman, N. E., Carter, R. L., Grisanti, L. A., Brailoiu, G. C., Madesh, M., Cheung, J. Y., Force, T., Abood, M. E., Koch, W. J., Tilley, D. G., and Brailoiu, E. (2013) Differential Activation of Cultured Neonatal Cardiomyocytes by Plasmalemmal Versus Intracellular G Protein-coupled Receptor 55 J. Biol. Chem. 288, 22481-22492
17. Brailoiu, G. C., Oprea, T. I., Zhao, P., Abood, M. E., and Brailoiu, E. (2011) Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide J. Biol. Chem. 286, 29166-29174
18. Deliu, E., Brailoiu, G. C., Eguchi, S., Hoffman, N. E., Rabinowitz, J. E., Tilley, D. G., Madesh, M., Koch, W. J., and Brailoiu, E. (2014) Direct evidence of intracrine angiotensin II signaling in neurons Am. J. Physiol. 306, C736-C744
19. 2+ signal elicits nitric oxide production in endothelial cells J. Biol. Chem. 287, 41023-41031
20. 2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260, 3440-3450
21. Bowman, E. J., Siebers, A., and Altendorf, K. (1988) Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells Proc. Natl. Acad. Sci. U.S.A. 85, 7972-7976
22. Kunz, J. B., Schwarz, H., and Mayer, A. (2004) Determination of four sequential stages during microautophagy in vitro J. Biol. Chem. 279, 9987-9996
23. Wang, T., Ming, Z., Xiaochun, W., and Hong, W. (2011) Rab7: Role of its protein interaction cascades in endo-lysosomal traffic Cell. Signalling 23, 516-521
24. Mukai, H., Munekata, E., and Higashijima, T. (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding J. Biol. Chem. 267, 16237-16243
25. Naylor, E., Arredouani, A., Vasudevan, S. R., Lewis, A. M., Parkesh, R., Mizote, A., Rosen, D., Thomas, J. M., Izumi, M., Ganesan, A., Galione, A., and Churchill, G. C. (2009) Identification of a chemical probe for NAADP by virtual screening Nat. Chem. Biol. 5, 220-226
26. Jalink, K. and Moolenaar, W. H. (2010) G protein-coupled receptors: The inside story BioEssays 32, 13-16
27. Zhu, T., Gobeil, F., Vazquez-Tello, A., Leduc, M., Rihakova, L., Bossolasco, M., Bkaily, G., Peri, K., Varma, D. R., Orvoine, R., and Chemtob, S. (2006) Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: A paradigm based on PGE2, PAF, and LPA1 receptors Can. J. Physiol. Pharmacol. 84, 377-391
28. 1 receptors regulate neuronal energy metabolism Nat. Neurosci. 15, 558-564
29. Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., Mechoulam, R., and Pertwee, R. G. (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors Pharmacol. Rev. 54, 161-202
30. Glass, M. and Felder, C. C. (1997) Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a Gs linkage to the CB1 receptor J. Neurosci. 17, 5327-5333
31. Lauckner, J. E., Hille, B., and Mackie, K. (2005) The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins Proc. Natl. Acad. Sci. U.S.A. 102, 19144-19149
32. 2+ transient in NG108-15 cells J. Biochem. 122, 890-895
33. 2+ in neuroblastoma x glioma hybrid NG108-15 cells Biochem. Biophys. Res. Commun. 229, 58-64
34. Shoemaker, J. L., Ruckle, M. B., Mayeux, P. R., and Prather, P. L. (2005) Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors J. Pharmacol. Exp. Ther. 315, 828-838
35. Irannejad, R., Tomshine, J. C., Tomshine, J. R., Chevalier, M., Mahoney, J. P., Steyaert, J., Rasmussen, S. G., Sunahara, R. K., El-Samad, H., Huang, B., and von Zastrow, M. (2013) Conformational biosensors reveal GPCR signalling from endosomes Nature 495, 534-538
36. Deliu, E., Tica, A. A., Motoc, D., Brailoiu, G. C., and Brailoiu, E. (2011) Intracellular angiotensin II activates rat myometrium Am. J. Physiol. 301, C559-C565
37. 2+ mobilization from lysosomes in pancreatic acinar cells J. Biol. Chem. 285, 38251-38259
38. 2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: Attenuation of hepatic fibrosis by CD38 ablation J. Biol. Chem. 285, 576-582
39. 2+ signaling occurs via second messenger release from intraorganelle synthesis sites Curr. Biol. 18, 1612-1618
40. Grimsey, N. L., Goodfellow, C. E., Dragunow, M., and Glass, M. (2011) Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway Biochim. Biophys. Acta 1813, 1554-1560
41. Hashimotodani, Y., Ohno-Shosaku, T., Tanimura, A., Kita, Y., Sano, Y., Shimizu, T., Di Marzo, V., and Kano, M. (2013) Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: Evidence for on-demand biosynthesis of 2-arachidonoylglycerol J. Physiol. 591, 4765-4776