Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages

  Harpole, Tyler J ^a   Grosman, Claudio ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Glutamate rotamers; Nicotinic receptor

Indexed keywords

GLUTAMIC ACID DERIVATIVE; ION CHANNEL; NICOTINIC RECEPTOR;

ADULT; ARTICLE; CATALYSIS; ION CONDUCTANCE; ION TRANSPORT; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STEREOCHEMISTRY;

GLUTAMATE ROTAMERS; NICOTINIC RECEPTOR;

ANIMALS; ELECTRICITY; GLUTAMATES; GLUTAMINE; ION CHANNEL GATING; MICE; MODELS, MOLECULAR; MUSCLES; MUTATION; PERMEABILITY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, NICOTINIC; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84905671438     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408950111     Document Type: Article

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