Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition

Phytotherapy Research

Volumn 28, Issue 8, 2014, Pages 1224-1231

  Lu, Guo Xun ^a   Bian, Di Fei ^a   Ji, Yu ^a   Guo, Jiao Mei ^a   Wei, Zhi Feng ^a   Jiang, Si De ^a   Xia, Yu Feng ^a   Dai, Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

collagen deposition; extracellular matrix; madecassoside; pulmonary fibrosis; TGF 1 overexpression

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; COLLAGEN; GLUTATHIONE; INTERSTITIAL COLLAGENASE; MADECASSOSIDE; MALONALDEHYDE; MYELOPEROXIDASE; PREDNISONE; SAPONIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CENTELLA ASIATICA; COLLAGEN DEPOSITION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; ENZYME REPRESSION; EXPERIMENTAL PULMONARY FIBROSIS; EXTRACELLULAR MATRIX; FEMALE; IN VITRO STUDY; LEUKOCYTE COUNT; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

CENTELLA ASIATICA; MUS;

COLLAGEN DEPOSITION; EXTRACELLULAR MATRIX; MADECASSOSIDE; PULMONARY FIBROSIS; TGF-Β1 OVEREXPRESSION;

ACTINS; ANIMALS; BLEOMYCIN; COLLAGEN; FEMALE; FIBROBLASTS; INFLAMMATION; LUNG; MATRIX METALLOPROTEINASE 13; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PHOSPHORYLATION; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENES;

EID: 84905664850     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5120     Document Type: Article

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