Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Szpakowicz, Anna ^a   Kiliszek, Marek ^b   Pepinski, Witold ^a   Waszkiewicz, Ewa ^a   Franaszczyk, Maria ^c   Skawronska, Małgorzata ^a   Ploski, Rafal ^b   Niemcunowicz Janica, Anna ^a   Dobrzycki, Sławomir ^a   Opolski, Grzegorz ^b   Musial, Włodzimierz Jerzy ^a   Kaminski, Karol Adam ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c INSTITUTE OF CARDIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 9P; CHROMOSOME 9P21; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENOTYPE; HETEROZYGOTE; HIGH RISK PATIENT; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; REGISTER; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; SURVIVAL; AGED; CHROMOSOME 9; GENETICS; MIDDLE AGED; MYOCARDIAL INFARCTION; PROPORTIONAL HAZARDS MODEL;

AGED; CHROMOSOMES, HUMAN, PAIR 9; FEMALE; GENETIC LOCI; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 84905658083     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104635     Document Type: Article

References (37)

1. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, et al. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678. (Pubitemid 46889737)
2. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, et al. (2007) Genome-wide association analysis of coronary artery disease. N Engl J Med 357: 443-453. (Pubitemid 47204873)
3. Koch W, Türk S, Erl A, Hoppmann P, Pfeufer A, et al. (2011) The chromosome 9p21 region and myocardial infarction in a European population. Atherosclerosis 217: 220-226.
4. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, et al. (2007) A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction. Science 316: 1491-1493. (Pubitemid 46906618)
5. Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, et al. (2009) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy-number variants. Nat Genet 41: 334-341.
6. O'Donnell CJ, Kavousi M, Smith AV, Kardia SL, Feitosa MF, et al. (2011) Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation 124: 2855-2864.
7. Takeuchi F, Yokota M, Yamamoto K, Nakashima E, Katsuya T, et al. (2012) Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet 20: 333-340.
8. Lee JY, Lee BS, Shin DJ, Woo Park K, Shin YA, et al. (2013) A genome-wide association study of a coronary artery disease risk variant. J Hum Genet 58: 120-126.
9. Butterworth AS, Braund PS, Farrall M, Hardwick RJ, Saleheen D, et al. (2011) Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet 7: e1002260.
10. Scheffold T, Kullmann S, Huge A, Binner P, Ochs HR, et al. (2011) Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry. BMC Cardiovasc Disord 11: 9.
11. Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, et al. (2007) Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336. (Pubitemid 46871653)
12. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341. (Pubitemid 46871654)
13. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genomewide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345. (Pubitemid 46871655)
14. Cugino D, Gianfagna F, Santimone I, de Gaetano G, Donati MB, et al. (2012) Type 2 diabetes and polymorphisms on chromosome 9p21: A meta-analysis. Nutr Metab Cardiovasc Dis 22: 619-625.
15. Nambi V, Boerwinkle E, Lawson K, Brautbar A, Chambless L, et al. (2012) The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 222: 135-137.
16. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, et al. (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8: 27-32. (Pubitemid 24274057)
17. Cannon-Albright LA, Goldgar DE, Meyer LJ, Lewis CM, Anderson DE, et al. (1992) Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science 258: 1148-1152.
18. Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, et al. (2012) Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. Atherosclerosis 220: 449-455.
19. Congrains A, Kamide K, Katsuya T, Yasuda O, Oguro R, et al. (2012) CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC. Biochem Biophys Res Commun 419: 612-616.
20. Kalinina N, Agrotis A, Antropova Y, Ilyinskaya O, Smirnov V, et al. (2004) Smad expression in human atherosclerotic lesions: evidence for impaired TGF-b/Smad signaling in smooth muscle cells of fibrofatty lesions. Arterioscler. Thromb Vasc Biol 24: 1391-1396. (Pubitemid 39050430)
21. Schmid M, Sen M, Rosenbach MD, Carrera CJ, Friedman H, et al. (2000) A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. Oncogene 19: 5747-5754.
22. Buysschaert I, Carruthers KF, Dunbar DR, Peuteman G, Rietzschel E, et al. (2010) A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: The GRACE Genetics Study. Eur Heart J 31: 1132-1141.
23. Ellis KL, Pilbrow AP, Frampton CM, Doughty RN, Whalley GA, et al. (2010) A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circ Cardiovasc Genet 3: 286-293.
24. Peng WH, Lu L, Zhang Q, Zhang RY, Wang LJ, et al. (2009) Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese. Clin Chem Lab Med 47: 917-922.
25. Horne BD, Carlquist JF, Muhlestein JB, Bair TL, Anderson JL (2008) Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease. Circ Cardiovasc Genet 1: 85-92.
26. Gong Y, Beitelshees AL, Cooper-DeHoff RM, Lobmeyer MT, Langaee TY, et al. (2011) Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet 4: 169-178.
27. Patel RS, Eapen DJ, Zafari AM, Vaccarino V, Quyyumi AA (2011) Letter by Patel et Al regarding article "Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease". Circ Cardiovasc Genet 4: e11.
28. Szpakowicz A, Pepinski W, Waszkiewicz E, Maciorkowska D, Skawronska M (2013) Polymorphism of 9p21.3 locus is associated with 5-year survival in highrisk patients with myocardial infarction. PLoS One 8: e72333.
29. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, et al. (2003) Global Registry of Acute Coronary Events Investigators. Predictors of hospital mortality in the Global Registry of Acute Coronary Events. Arch Intern Med 163: 2345-2353. (Pubitemid 37310196)
30. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, et al. (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32: 2999-3054.
31. Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, et al. (2006) Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ 333: 1091-1094. (Pubitemid 44863647)
32. Eagle KA, Lim MJ, Dabbous OH, Pieper KS, Goldberg RJ, et al. (2004) A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA 291: 2727-2733. (Pubitemid 38725422)
33. Global Registry of Acute Coronary Events website. Available: http://www.outcomes-umassmed.org/GRACE/grace-risk-table.aspx. Accessed 2013 Jul 25.
34. Ardissino D, Berzuini C, Merlini PA, Mannuccio Mannucci P, et al. (2011) Investigators. Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction. J Am Coll Cardiol 58: 426-434.
35. Patel RS, Su S, Neeland IJ, Ahuja A, Veledar E, et al. (2010) The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J 31: 3017-3024.
36. Wang W, Peng WH, Lu L, Zhang RY, Zhang Q, et al. (2011) Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients. Chin Med J 124: 66-71.
37. de Araujo Goncalves P, Ferreira J, Aguiar C, Seabra-Gomes R (2005) TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J. 26: 865-872.