Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages 11515-11520

  Tränkner, Dimitri ^a   Hahne, Nadeau ^a   Sugino, Ken ^a   Hoon, Mark A ^b   Zuker, Charles ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c Department of Biochemistry and Molecular Biophysics Columbia College of Physicians and Surgeons Columbia University ^*  (United States)

Author keywords

Airway inflammation; Bronchospasms

Indexed keywords

OVALBUMIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOCONSTRICTION; CELL POPULATION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CELL;

AIRWAY INFLAMMATION; BRONCHOSPASMS;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; GENE DELETION; GENE SILENCING; MICE; MICE, INBRED C57BL; PNEUMONIA; RECEPTORS, LYSOSPHINGOLIPID; RESPIRATORY SYSTEM; SENSORY RECEPTOR CELLS; TRPV CATION CHANNELS; VAGUS NERVE;

EID: 84905638795     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411032111     Document Type: Article

References (37)

1. Anonymous (2014) Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2014. Available at: http://www.ginasthma. org/.
2. Program NAEaP (2007) Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (National Institutes of Health, Bethesda, MD), p 440.
3. Katsumoto TR, et al. (2013) The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest 123(5):2037-2048.
4. McFadden ER, Jr., Warren EL (1997) Observations on asthma mortality. Ann Intern Med 127(2):142-147.
5. Locksley RM (2010) Asthma and allergic inflammation. Cell 140(6):777-783.
6. Vercelli D (2008) Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 8(3):169-182.
7. Reddy D, Little FF (2013) Glucocorticoid-resistant asthma: More than meets the eye. J Asthma 50(10):1036-1044.
8. Gu X, et al. (2014) Chemosensory functions for pulmonary neuroendocrine cells. Am J Respir Cell Mol Biol 50(3):637-646.
9. Barnes PJ (1986) Asthma as an axon reflex. Lancet 1(8475):242-245.
10. Undem BJ, Carr MJ (2002) The role of nerves in asthma. Curr Allergy Asthma Rep 2(2):159-165.
11. Geppetti P, Patacchini R, Nassini R, Materazzi S (2010) Cough: The emerging role of the TRPA1 channel. Lung 188(Suppl 1):S63-S68.
12. Bessac BF, Jordt SE (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 23:360-370.
13. Hökfelt T, Kellerth JO, Nilsson G, Pernow B (1975) Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 100(2):235-252.
14. Adriaensen D, Timmermans JP (2011) Breath-taking complexity of vagal C-fibre nociceptors: Implications for inflammatory pulmonary disease, dyspnoea and cough. J Physiol 589(Pt 1):3-4.
15. Richardson JD, Vasko MR (2002) Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther 302(3):839-845. (Pubitemid 34920202)
16. Chiu IM, et al. (2013) Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-57.
17. Coleridge HM, et al. (1976) Stimulation of 'irritant' receptors and afferent C-fibres in the lungs by prostaglandins. Nature 264(5585):451-453.
18. Bautista DM, et al. (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124(6):1269-1282.
19. Springall DR, et al. (1987) Retrograde tracing shows that CGRP-immunoreactive nerves of rat trachea and lung originate from vagal and dorsal root ganglia. J Auton Nerv Syst 20(2):155-166. (Pubitemid 17144287)
20. Kummer W, Fischer A, Kurkowski R, Heym C (1992) The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry. Neuroscience 49(3):715-737.
21. Nials AT, Uddin S (2008) Mouse models of allergic asthma: Acute and chronic allergen challenge. Dis Model Mech 1(4-5):213-220.
22. Caceres AI, et al. (2009) A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci USA 106(22):9099-9104.
23. Ivanova A, et al. (2005) In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 43(3):129-135. (Pubitemid 41780912)
24. Mishra SK, Tisel SM, Orestes P, Bhangoo SK, Hoon MA (2011) TRPV1-lineage neurons are required for thermal sensation. EMBO J 30(3):582-593.
25. Saito M, et al. (2001) Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 19(8):746-750. (Pubitemid 32729536)
26. Pogorzala LA, Mishra SK, Hoon MA (2013) The cellular code for mammalian thermosensation. J Neurosci 33(13):5533-5541.
27. Gong S, et al. (2003) A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 425(6961):917-925. (Pubitemid 37376918)
28. Trifilieff A, Fozard JR (2012) Sphingosine-1-phosphate-induced airway hyperreactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor. J Pharmacol Exp Ther 342(2):399-406.
29. Ammit AJ, et al. (2001) Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB 15(7):1212-1214.
30. Trifilieff A, Baur F, Fozard JR (2009) Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. Naunyn Schmiedebergs Arch Pharmacol 380(4):303-309.
31. Brinkmann V, et al. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24):21453-21457. (Pubitemid 34952287)
32. Madisen L, et al. (2010) A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-140.
33. Zhang Y, et al. (2008) V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron 60(1):84-96.
34. Cavanaugh DJ, et al. (2009) Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci USA 106(22):9075-9080.
35. Caterina MJ, et al. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288(5464):306-313. (Pubitemid 30226186)
36. Davis GM, Coates AL, Dalle D, Bureau MA (1988) Measurement of pulmonary mechanics in the newborn lamb: A comparison of three techniques. J Appl Physiol (1985)64(3):972-981.
37. Hempel CM, Sugino K, Nelson SB (2007) A manual method for the purification of fluorescently labeled neurons from the mammalian brain. Nat Protoc 2(11):2924-2929.