Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 2, 2014, Pages 306-313

  Daham, Kameran ^a,b   James, Anna ^b   Balgoma, David ^b   Kupczyk, Maciej ^b   Billing, Bo ^a,b   Lindeberg, Agneta ^a,b   Henriksson, Elisabeth ^a,b   Fitzgerald, Garret A ^c   Wheelock, Craig E ^b   Dahlén, Sven Erik ^b   Dahlén, Barbro ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

airway hyperresponsiveness; Asthma; COX; eicosanoids; leukotrienes; mass spectrometry; NSAIDs; prostaglandin; thromboxane; urinary metabolites

Indexed keywords

ALLERGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETORICOXIB; LEUKOTRIENE E4; LIPID; METHACHOLINE; NITRIC OXIDE; PROSTAGLANDIN; PROSTAGLANDIN E2; THROMBOXANE; THROMBOXANE A2; CYCLOOXYGENASE 2 INHIBITOR; METHACHOLINE CHLORIDE; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; SULFONE; TETRANOR PROSTAGLANDIN M;

ADULT; ALLERGIC ASTHMA; ARTERIAL PRESSURE; ARTICLE; BIOSYNTHESIS; BRONCHOCONSTRICTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENZYME INHIBITION; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION TEST; LEUKOCYTE DIFFERENTIAL COUNT; LUNG FUNCTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROSTAGLANDIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFLAMMATION; SPUTUM ANALYSIS; URINARY EXCRETION; ASTHMA; CROSSOVER PROCEDURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; EOSINOPHIL; FEMALE; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; SPUTUM; URINE;

ADULT; ALLERGENS; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; CROSS-OVER STUDIES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INFLAMMATION; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; NITRIC OXIDE; PROSTAGLANDINS; PYRIDINES; SPUTUM; SULFONES;

EID: 84905588860     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.12.002     Document Type: Article

References (40)

1. T. Grosser, Y. Yu, and G.A. Fitzgerald Emotion recollected in tranquility: lessons learned from the COX-2 saga Annu Rev Med 61 2010 17 33
2. 2 on allergen-induced asthma Am Rev Respir Dis 148 1993 87 90
3. 2 in normal and asthmatic men N Engl J Med 311 1984 209 213
4. K. Daham, W.L. Song, J.A. Lawson, M. Kupczyk, A. Gülich, and S.E. Dahlén et al. Effects of celecoxib on major prostaglandins in asthma Clin Exp Allergy 41 2011 36 45
5. R.S. Peebles Jr., K. Hashimoto, J.D. Morrow, R. Dworski, R.D. Collins, and Y. Hashimoto et al. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice Am J Respir Crit Care Med 165 2002 1154 1160
6. L. Swedin, R. Ellis, T. Neimert-Andersson, Å. Ryrfeldt, G. Nilsson, and M. Inman et al. Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant Prostaglandins Other Lipid Mediat 92 2010 44 53
7. 4 excretion in aspirin-sensitive asthma Am J Respir Crit Care Med 153 1996 572 575
8. A. Szczeklik, L. Mastalerz, E. Nizankowska, and A. Cmiel Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma Am J Respir Crit Care Med 153 1996 567 571
9. 2 on allergen-induced airway responses and airway inflammation Am J Respir Crit Care Med 159 1999 31 36
10. D.D. Stevenson, and A. Szczeklik Clinical and pathologic perspectives on aspirin sensitivity and asthma J Allergy Clin Immunol 118 2006 773 786
11. B. Dahlén, A. Szczeklik, and J.J. Murray Celecoxib in patients with asthma and aspirin intolerance N Engl J Med 344 2001 142
12. A. Szczeklik, E. Niżankowska, G. Bochenek, K. Nagraba, F. Mejza, and M. Świerczyńska Safety of a specific COX-2 inhibitor in aspirin-induced asthma Clin Exp Allergy 31 2001 219 225
13. P. Gyllfors, G. Bochenek, J. Overholt, D. Drupka, M. Kumlin, and J. Sheller et al. Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib J Allergy Clin Immunol 111 2003 1116 1121
14. D. Riendeau, M.D. Percival, C. Brideau, S. Charleson, D. Dubé, and D. Ethier et al. Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2 J Pharm Exp Ther 296 2001 558 566
15. Z. Diamant, G.M. Gauvreau, D.W. Cockcroft, L.P. Boulet, P.J. Sterk, and F.H. de Jongh et al. Inhaled allergen bronchoprovocation tests J Allergy Clin Immunol 132 2013 1045 1055.e6
16. C. Brideau, S. Kargman, S. Liu, A.L. Dallob, E.W. Ehrich, and I.W. Rodger et al. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors Inflamm Res 45 1996 68 74
17. D. Balgoma, J. Larsson, J. Rockach, J.A. Lawson, K. Daham, and B. Dahlén et al. Quantification of lipid mediator metabolites in human urine by electrospray ionization mass spectrometry: signal suppression control Anal Chem 85 2013 7866 7874
18. A. Roquet, B. Dahlén, M. Kumlin, E. Ihre, G. Anstrén, and S. Binks et al. Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics Am J Resp Crit Care Med 155 1997 1856 1863
19. R.A. Dweik, P.B. Boggs, S.C. Erzurum, C.G. Irvin, M.W. Leigh, and J.O. Lundberg et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications Am J Respir Crit Care Med 184 2011 602 615
20. E. Pizzichini, M.M. Pizzichini, A. Efthimiadis, S. Evans, M.M. Morris, and D. Squillace et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements Am J Respir Crit Care Med 154 1996 308 317
21. M.L. Seymour, S. Rak, D. Åberg, G.C. Riise, J.F. Penrose, and Y. Kanaoka et al. Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics Am J Respir Crit Care Med 164 2001 2051 2056
22. L.S. Harrington, R. Lucas, S.K. McMaster, L. Moreno, G. Scadding, and T.D. Warner et al. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma FASEB J 22 2008 4005 4010
23. 2 receptors Br J Pharmacol 168 2013 794 806
24. A.J. Fairfax, J.M. Hanson, and J. Morley The late reaction following bronchial provocation with house dust mite allergen: dependence on arachidonic acid metabolism Clin Exp Immunol 52 1983 393 398
25. J.E. Fish, M.G. Ankin, N.F. Adkinson Jr., and V.I. Peterman Indomethacin modification of immediate-type immunologic airway responses in allergic asthmatic and non-asthmatic subjects: evidence for altered arachidonic acid metabolism in asthma Am Rev Respir Dis 123 1981 609 614
26. J.G. Kirby, F.E. Hargreave, D.W. Cockcroft, and P.M. O'Byrne Effect of indomethacin on allergen-induced asthmatic responses J Appl Physiol 66 1989 578 583
27. 4 in humans: effect of indomethacin Am Rev Respir Dis 141 1990 1441 1445
28. 2 - and allergen-induced bronchoconstriction J Appl Physiol 66 1989 1685 1693
29. P.J. Manning, W.H. Stevens, D.W. Cockcroft, and P.M. O'Byrne The role of thromboxane in allergen-induced asthmatic responses Eur Respir J 4 1991 667 672
30. 2 pathway upregulation: relation to asthma severity, control, and Th2 inflammation J Allergy Clin Immunol 131 2013 1504 1512
31. R. Pettipher, and M. Whittaker Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2): from lead optimization to clinical proof-of-concept in asthma and allergic rhinitis J Med Chem 55 2012 2915 2931
32. M.D. Lupinetti, J.R. Sheller, F. Catella, and G.A. Fitzgerald Thromboxane biosynthesis in allergen-induced bronchospasm: evidence for platelet activation Am Rev Respir Dis 140 1989 932 935
33. 4 and histamine in asthmatics Am Rev Respir Dis 146 1992 96 103
34. 2 biosynthesis in acute asthma and after antigen challenge Am Rev Respir Dis 143 1991 119 125
35. X. Norel, L. Walch, C. Labat, J.P. Gascard, E. Dulmet, and C. Brink Prostanoid receptors involved in the relaxation of human bronchial preparations Br J Pharmacol 126 1999 867 872
36. 2 by platelet COX-1 in mice and humans J Clin Invest 122 2012 1459 1468
37. B.F. McAdam, F. Catella-Lawson, I.A. Mardini, S. Kapoor, J.A. Lawson, and G.A. FitzGerald Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2 Proc Natl Acad Sci U S A 96 1999 272 277
38. Y. Yu, E. Ricciotti, R. Scalia, S.Y. Tang, G. Grant, and Z. Yu et al. Vascular COX-2 modulates blood pressure and thrombosis in mice Sci Transl Med 4 2012 132ra154
39. M.E. Wechsler, J.M. Kelley, I.E.O. Boyd, S. Dutile, G. Marigowda, and I. Kirsch et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma New Engl J Med 365 2011 119 126
40. M. Richter, and P. Sirois Effects of eicosanoids, neuromediators and bioactive peptides on murine airways Eur J Pharmacol 389 2000 225 234