Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: A randomized controlled trial

Nutrition

Volumn 30, Issue 9, 2014, Pages 1034-1039

  Jung, Eun Soo ^a   Park, Soo Hyun ^a   Choi, Eun Kyung ^a   Ryu, Beun Ho ^b   Park, Byung Hyun ^a   Kim, Dal Sik ^a   Kim, Young Gon ^a   Chae, Soo Wan ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Doul Farming Corporation Namhae Gohyun Chamyeon   (South Korea)

Author keywords

Aqueous extraction; Atherogenic marker; Cholesterol; Clinical trial; Garlic

Indexed keywords

FATTY ACID; GARLIC EXTRACT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL; APOLIPOPROTEIN B; HYPOCHOLESTEROLEMIC AGENT; LIPID; PLANT MEDICINAL PRODUCT;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EVENING DOSAGE; FATTY ACID BLOOD LEVEL; FEMALE; FOOD INTAKE; HEART PROTECTION; HUMAN; HUMAN EXPERIMENT; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; MIDDLE AGED; MORNING DOSAGE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; GARLIC;

ALLIUM NIGRUM; ALLIUM SATIVUM;

ADULT; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEINS B; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GARLIC; HUMANS; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; MIDDLE AGED; PLANT PREPARATIONS; TRIGLYCERIDES;

EID: 84905569865     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2014.02.014     Document Type: Article

References (35)

1. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002, 106:3143-3421.
2. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
3. Davidson M.H. Apolipoprotein measurements: is more widespread use clinically indicated?. Clin Cardiol 2009, 32:482-486.
4. Walldius G., Jungner I. The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy-a review of the evidence. J Intern Med 2006, 259:493-519.
5. Elovson J., Chatterton J.E., Bell G.T., Schumaker V.N., Reuben M.A., Puppione D.L., et al. Plasma very low density lipoproteins contain a single molecule of apolipoprotein B. J Lipid Res 1988, 29:1461-1473.
6. Jungner I., Sniderman A.D., Furberg C., Aastveit A.H., Holme I., Walldius G. Does low-density lipoprotein size add to atherogenic particle number in predicting the risk of fatal myocardial infarction?. Am J Cardiol 2006, 97:943-946.
7. Sniderman A.D., St-Pierre A.C., Cantin B., Dagenais G.R., Despres J.P., Lamarche B. Concordance/discordance between plasma apolipoprotein B levels and the cholesterol indexes of atherosclerotic risk. Am J Cardiol 2003, 91:1173-1177.
8. Wagner A.M., Jorba O., Rigla M., Alonso E., Ordonez-Llanos J., Perez A. LDL-cholesterol/apolipoprotein B ratio is a good predictor of LDL phenotype B in type 2 diabetes. Acta Diabetol 2002, 39:215-220.
9. Austin M.A., Breslow J.L., Hennekens C.H., Buring J.E., Willett W.C., Krauss R.M. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988, 260:1917-1921.
10. Campos H., Blijlevens E., McNamara J.R., Ordovas J.M., Posner B.M., Wilson P.W., et al. LDL particle size distribution. Results from the Framingham Offspring Study. Arterioscler Thromb 1992, 12:1410-1419.
11. Mykkanen L., Kuusisto J., Haffner S.M., Laakso M., Austin M.A. LDL size and risk of coronary heart disease in elderly men and women. Arterioscler Thromb Vasc Biol 1999, 19:2742-2748.
12. Rahman K. Garlic and aging: new insights into an old remedy. Ageing Res Rev 2003, 2:39-56.
13. Iciek M., Kwiecien I., Wlodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen 2009, 50:247-265.
14. Bordia A., Verma S.K., Srivastava K.C. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1998, 58:257-263.
15. Koseoglu M., Isleten F., Atay A., Kaplan Y.C. Effects of acute and subacute garlic supplement administration on serum total antioxidant capacity and lipid parameters in healthy volunteers. Phytother Res 2010, 24:374-378.
16. Rahman K., Lowe G.M. Garlic and cardiovascular disease: a critical review. J Nutr 2006, 136:736S-740S.
17. Ried K., Frank O.R., Stocks N.P. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Eur J Clin Nutr 2013, 67:64-70.
18. El-Bayoumy K., Sinha R., Pinto J.T., Rivlin R.S. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr 2006, 136:864S-869S.
19. Berthold H.K., Sudhop T., von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial. JAMA 1998, 279:1900-1902.
20. Isaacsohn J.L., Moser M., Stein E.A., Dudley K., Davey J.A., Liskov E., et al. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med 1998, 158:1189-1194.
21. Neil H.A., Silagy C.A., Lancaster T., Hodgeman J., Vos K., Moore J.W., et al. Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J R Coll Physicians Lond 1996, 30:329-334.
22. Amagase H., Petesch B.L., Matsuura H., Kasuga S., Itakura Y. Intake of garlic and its bioactive components. J Nutr 2001, 131:955S-962S.
23. Gardner C.D., Chatterjee L.M., Carlson J.J. The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Atherosclerosis 2001, 154:213-220.
24. Ried K., Toben C., Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev 2013, 71:282-299.
25. Avci A., Atli T., Erguder I.B., Varli M., Devrim E., Aras S., et al. Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects. Gerontology 2008, 54:173-176.
26. Steiner M., Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr 2001, 131:980S-984S.
27. Common Terminology Criteria for Adverse Events. Available at Accessed on July 12, 2010. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm.
28. Harmonised Tripartite Guideline for Good Clinical Practice Available at Accessed on April 01, 2010. http://www.ich.org/products/guidelines/efficacy/article/efficacy-guidelines.html.
29. Lee H.S., Yang S.T., Ryu B.H. Effects of aged black garlic extract on lipid improvement in rats fed with high fat-cholesterol diet. J Life Sci 2011, 21:884-892.
30. Durak I., Kavutcu M., Aytac B., Avci A., Devrim E., Ozbek H., et al. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem 2004, 15:373-377.
31. Yeh Y.Y., Yeh S.M. Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract. J Nutr 2006, 136:745S-749S.
32. Williams M.J., Sutherland W.H., McCormick M.P., Yeoman D.J., de Jong S.A. Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res 2005, 19:314-319.
33. Lin M.C., Wang E.J., Lee C., Chin K.T., Liu D., Chiu J.F., et al. Garlic inhibits microsomal triglyceride transfer protein gene expression in human liver and intestinal cell lines and in rat intestine. J Nutr 2002, 132:1165-1168.
34. Budoff M.J., Ahmadi N., Gul K.M., Liu S.T., Flores F.R., Tiano J., et al. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med 2009, 49:101-107.
35. Yeh Y.Y., Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr 2001, 131:989S-993S.