Aged garlic extract reduces blood pressure in hypertensives: A dose-response trial

European Journal of Clinical Nutrition

Volumn 67, Issue 1, 2013, Pages 64-70

  Ried, K ^a,b   Frank, O R ^a   Stocks, N P ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b National Institute of Integrative Medicine   (Australia)

Author keywords

Garlic; Hypertension; Nutritional medicine

Indexed keywords

AGED GARLIC EXTRACT; ANTIHYPERTENSIVE AGENT; PLANT EXTRACT; S ALLYLCYSTEINE; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BLOATING; BLOOD PRESSURE MONITORING; CONSTIPATION; CONTROLLED STUDY; COUGHING; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FLATULENCE; GARLIC TASTE; GASTROINTESTINAL REFLUX; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PATIENT COMPLIANCE; PATIENT SATISFACTION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; TASTE; XEROSTOMIA;

ADULT; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; CAPSULES; COMBINED MODALITY THERAPY; CYSTEINE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GARLIC; HUMANS; HYPERTENSION; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PATIENT DROPOUTS; PLANT EXTRACTS; PLANT ROOTS;

ALLIUM SATIVUM;

EID: 84872132092     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2012.178     Document Type: Article

References (29)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217-223. (Pubitemid 40138015)
2. Martiniuk AL, Lee CM, Lawes CM, Ueshima H, Suh I, Lam TH et al. Hypertension: its prevalence and population-attributable fraction for mortality from cardiovascular disease in the Asia-Pacific region. J Hypertens 2007; 25: 73-79. (Pubitemid 44885666)
3. Briganti EM, Shaw JE, Chadban SJ, Zimmet PZ, Welborn TA, McNeil JJ et al. Untreated hypertension among Australian adults: the 1999-2000 Australian Diabetes, Obesity and Lifestyle Study. Med J Aust 2003; 179: 135-139. (Pubitemid 37025189)
4. Olsen H, Klemetsrud T, Stokke HP, Tretli S, Westheim A. Adverse drug reactions in current antihypertensive therapy: a general practice survey of 2586 patients in Norway. Blood Press 1999; 8: 94-101. (Pubitemid 29359483)
5. Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. J Clin Pharm Ther 2001; 26: 331-342. (Pubitemid 32989555)
6. Wood MJ, Stewart RL, Merry H, Johnstone DE, Cox JL. Use of complementary and alternative medical therapies in patients with cardiovascular disease. Am Heart J 2003; 145: 806-812. (Pubitemid 36570950)
7. Yeh GY, Davis RB, Phillips RS. Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol 2006; 98: 673-680. (Pubitemid 44233469)
8. Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord 2008; 8: 13.
9. Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. Ann Pharmacother 2008; 42: 1766-1771.
10. Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 2010; 67: 144-150.
11. Lawson LD, Gardner CD. Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem 2005; 53: 6254-6261. (Pubitemid 41169369)
12. Hoshino T, Kashimoto N, Kasuga S. Effects of garlic preparations on the gastrointestinal mucosa. J Nutr 2001; 131: 1109S-1113SS.
13. Harauma A, Moriguchi T. Aged garlic extract improves blood pressure in spontaneously hypertensive rats more safely than raw garlic. J Nutr 2006; 136: 769S-773SS.
14. Macan H, Uykimpang R, Alconcel M, Takasu J, Razon R, Amagase H et al. Aged garlic extract may be safe for patients on warfarin therapy. J Nutr 2006; 136: 793S-795SS.
15. Al-Qattan KK, Thomson M, Al-Mutawa'a S, Al-Hajeri D, Drobiova H, Ali M. Nitric oxide mediates the blood-pressure lowering effect of garlic in the rat two-kidney, one-clip model of hypertension. J Nutr 2006; 136: 774S-776SS.
16. Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA 2007; 104: 17977-17982. (Pubitemid 350210806)
17. Castro C, Lorenzo AG, Gonzalez A, Cruzado M. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: involvement of cell-cycle inhibitor p27(Kip1) and mitogen-activated protein kinase. Mol Nutr Food Res 2010; 54: 781-787.
18. Suetsuna K. Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L. (garlic). J Nutr Biochem 1998; 9: 415-419. (Pubitemid 28561541)
19. PEN Computer Systems Pty Ltd, Parramatta, NSW, Australia. Available at http://www.clinicalaudit.com.au/.
20. Kyolic Garlic High Potency Everyday Formula 112. Wagner, Vitaco Health (NZ) Ltd, Sydney, Australia. Available at http://www.wagnerproducts.com.au/ products-andsupplements/product-list/product-details/-prod-/Kyolic-High-Potency- Everyday-Formula.
21. Ried K, Frank OR, Stocks NP. Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. BMC Complement Altern Med 2009; 9: 22.
22. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903-1913. (Pubitemid 35472129)
23. McInnes GT. Lowering blood pressure for cardiovascular risk reduction. J Hypertens Suppl 2005; 23: S3-S8.
24. Beck E, Gruenwald J. Allium sativum in der Stufentherapie der Hyperlipidaemie. Med Welt 1993; 44: 516-520.
25. Borrelli F, Capasso R, Izzo AA. Garlic (Allium sativum L.): adverse effects and drug interactions in humans. Mol Nutr Food Res 2007; 51: 1386-1397. (Pubitemid 350195612)
26. Waring RH, Klovrza LZ, Harris RM. Diet and individuality in detoxification. J Nutr Environ Med 2007; 16: 95-105. (Pubitemid 350194058)
27. Meletis CD. Cleansing of the human body. A daily essential process. Altern Complement Therap 2001; 7: 196-202.
28. Taverne K, de Groot M, de Boer A, Klungel O. Genetic polymorphisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs. Expert Opin Drug Metab Toxicol 2010; 6: 439-460.
29. Casiglia E, Tikhonoff V, Mazza A, Rynkiewicz A, Limon J, Caffi S et al. C-344T polymorphism of the aldosterone synthase gene and blood pressure in the elderly: a population-based study. J Hypertens 2005; 23: 1991-1996. (Pubitemid 41830393)