Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc

International Journal of Cardiology

Volumn 175, Issue 3, 2014, Pages 446-450

  Shi, Yi ^a,b   Savarese, Gianluigi ^a,c   Perrone Filardi, Pasquale ^c   Lüscher, Thomas F ^a   Camici, Giovanni G ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aging; Endothelial dysfunction; ROS

Indexed keywords

1 HYDROXY 3 METHOXYCARBONYL 2,2,5,5 TETRAMETHY PYRROLIDINE; ACETYLCHOLINE; NITROPRUSSIDE SODIUM; PROTEIN P66; PYRROLIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PROTEIN SHC; SHC1 PROTEIN, MOUSE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BASILAR ARTERY; BODY WEIGHT; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMORAL ARTERY; GENE DELETION; GENE FUNCTION; MOUSE; MUSCLE ISOMETRIC CONTRACTION; MYOGRAPHY; NEUROLOGIC EXAMINATION; NONHUMAN; P66SHC GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; SPIN TRAPPING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; KNOCKOUT MOUSE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

AGING; ANIMALS; BASILAR ARTERY; CEREBROVASCULAR DISORDERS; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; SHC SIGNALING ADAPTOR PROTEINS;

EID: 84905560615     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.06.025     Document Type: Article

References (24)

1. B.J. North, and D.A. Sinclair The intersection between aging and cardiovascular disease Circ Res 110 2012 1097 1108
2. B. van der Loo, R. Labugger, and J.N. Skepper et al. Enhanced peroxynitrite formation is associated with vascular aging J Exp Med 192 2000 1731 1744
3. R. Pluta, J. Jolkkonen, S. Cuzzocrea, F. Pedata, D. Cechetto, and A. Popa-Wagner Cognitive impairment with vascular impairment and degeneration Curr Neurovasc Res 8 2011 342 350
4. P.B. Gorelick, A. Scuteri, and S.E. Black et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke 42 2011 2672 2713
5. D. Harman Aging: a theory based on free radical and radiation chemistry J Gerontol 11 1956 298 300
6. A.A. Miller, G.R. Drummond, H. Schmidt, and C.G. Sobey NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries Circ Res 97 2005 1055 1062
7. P. Francia, C.D. Gatti, and M. Bachschmid et al. Deletion of p66(shc) gene protects against age-related endothelial dysfunction Circulation 110 2004 2889 2895
8. E. Beltrami, S. Valtorta, and R. Moresco et al. The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis Curr Pharm Des 19 2013 2708 2714
9. C. Napoli, I. Martin-Padura, and F. de Nigris et al. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet Proc Natl Acad Sci U S A 100 2003 2112 2116
10. I. Martin-Padura, F. de Nigris, and E. Migliaccio et al. p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice Endothelium 15 2008 276 287
11. E. Pagnin, G. Fadini, R. de Toni, A. Tiengo, L. Calo, and A. Avogaro Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress J Clin Endocrinol Metab 90 2005 1130 1136
12. G.G. Camici, M. Schiavoni, and P. Francia et al. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress Proc Natl Acad Sci U S A 104 2007 5217 5222
13. G. Zaccagnini, F. Martelli, and P. Fasanaro et al. p66ShcA modulates tissue response to hindlimb ischemia Circulation 109 2004 2917 2923
14. R.D. Spescha, Y. Shi, and S. Wegener et al. Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury Eur Heart J 34 2013 96 103
15. Y. Noda, S. Yamagishi, and T. Matsui et al. The p66shc gene expression in peripheral blood monocytes is increased in patients with coronary artery disease Clin Cardiol 33 2010 548 552
16. F. Cosentino, P. Francia, G.G. Camici, P.G. Pelicci, T.F. Luscher, and M. Volpe Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein Arterioscler Thromb Vasc Biol 28 2008 622 628
17. M.J. Mulvany, and W. Halpern Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats Circ Res 41 1977 19 26
18. W. Auch-Schwelk, Z.S. Katusic, and P.M. Vanhoutte Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta Hypertension 19 1992 442 445
19. K. Berg, M. Ericsson, M. Lindgren, and H. Gustafsson A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies PLoS One 9 2014 e90964
20. Y. Shi, R.Y. Man, and P.M. Vanhoutte Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats Acta Pharmacol Sin 29 2008 185 192
21. Y. Shi, G.G. Camici, and T.F. Luscher Cardiovascular determinants of life span Pflugers Arch 459 2009 315 324
22. R.A. Floyd, and K. Hensley Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases Neurobiol Aging 23 2002 795 807
23. L. Park, J. Anrather, H. Girouard, P. Zhou, and C. Iadecola Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain J Cereb Blood Flow Metab 27 2007 1908 1918
24. A.M. Beyer, G.L. Baumbach, and C.M. Halabi et al. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling Hypertension 51 2008 867 871