-
1
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
-
(2013)
CA Cancer J Clin
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
2
-
-
84863707351
-
Cancer treatment and survivorship statistics, 2012
-
Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62(4):220-241.
-
(2012)
CA Cancer J Clin
, vol.62
, Issue.4
, pp. 220-241
-
-
Siegel, R.1
Desantis, C.2
Virgo, K.3
-
3
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346(2):92-98.
-
(2002)
N Engl J Med
, vol.346
, Issue.2
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
4
-
-
33847276516
-
Randomized Phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan
-
Ohe Y, Ohashi Y, Kubota K, et al. Randomized Phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol. 2007;18(2):317-323.
-
(2007)
Ann Oncol
, vol.18
, Issue.2
, pp. 317-323
-
-
Ohe, Y.1
Ohashi, Y.2
Kubota, K.3
-
5
-
-
77958478674
-
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
-
Pao W, Chmielecki J. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer. 2010;10(11): 760-774.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.11
, pp. 760-774
-
-
Pao, W.1
Chmielecki, J.2
-
6
-
-
0012381722
-
Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
-
Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol. 2003;21(12):2237-2246.
-
(2003)
J Clin Oncol
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
7
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003;290(16):2149-2158.
-
(2003)
JAMA
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
8
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366(9496):1527-1537.
-
(2005)
Lancet
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
9
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129-2139.
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
10
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004; 304(5676):1497-1500.
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
11
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101(36):13306-13311.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
12
-
-
79960702788
-
Biomarker analyses and final overall survival results from a Phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
-
Fukuoka M, Wu YL, Thongprasert S, et al. Biomarker analyses and final overall survival results from a Phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol. 2011;29(21):2866-2874.
-
(2011)
J Clin Oncol
, vol.29
, Issue.21
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
-
13
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10): 947-957.
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
14
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353(2): 123-132.
-
(2005)
N Engl J Med
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues, P.J.2
Ciuleanu, T.3
-
15
-
-
0035939330
-
Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
-
Barker AJ, Gibson KH, Grundy W, et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett. 2001;11(14):1911-1914.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, Issue.14
, pp. 1911-1914
-
-
Barker, A.J.1
Gibson, K.H.2
Grundy, W.3
-
16
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer JD, Barbacci EG, Iwata KK, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997;57(21):4838-4848.
-
(1997)
Cancer Res
, vol.57
, Issue.21
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
-
17
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361(10): 958-967.
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
-
18
-
-
24344459713
-
Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients
-
Cortes-Funes H, Gomez C, Rosell R, et al. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann Oncol. 2005;16(7):1081-1086.
-
(2005)
Ann Oncol
, vol.16
, Issue.7
, pp. 1081-1086
-
-
Cortes-Funes, H.1
Gomez, C.2
Rosell, R.3
-
19
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
-
Mitsudomi T, Kosaka T, Endoh H, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol. 2005;23(11):2513-2520.
-
(2005)
J Clin Oncol
, vol.23
, Issue.11
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
-
20
-
-
33646418681
-
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation
-
Han SW, Kim TY, Jeon YK, et al. Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. Clin Cancer Res. 2006;12(8):2538-2544.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.8
, pp. 2538-2544
-
-
Han, S.W.1
Kim, T.Y.2
Jeon, Y.K.3
-
21
-
-
35548962203
-
Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
-
Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci. 2007;98(12):1817-1824.
-
(2007)
Cancer Sci
, vol.98
, Issue.12
, pp. 1817-1824
-
-
Mitsudomi, T.1
Yatabe, Y.2
-
22
-
-
84883556206
-
Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: Focus on epidermal growth factor receptor mutation testing and mutation-positive patients
-
Roengvoraphoj M, Tsongalis GJ, Dragnev KH, Rigas JR. Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: focus on epidermal growth factor receptor mutation testing and mutation-positive patients. Cancer Treat Rev. 2013;39(8):839-850.
-
(2013)
Cancer Treat Rev
, vol.39
, Issue.8
, pp. 839-850
-
-
Roengvoraphoj, M.1
Tsongalis, G.J.2
Dragnev, K.H.3
Rigas, J.R.4
-
23
-
-
33746034167
-
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
-
Jackman DM, Yeap BY, Sequist LV, et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res. 2006;12(13):3908-3914.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.13
, pp. 3908-3914
-
-
Jackman, D.M.1
Yeap, B.Y.2
Sequist, L.V.3
-
24
-
-
32944481596
-
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
-
Riely GJ, Pao W, Pham D, et al. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res. 2006;12(3 Pt 1):839-844.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.3 PART 1
, pp. 839-844
-
-
Riely, G.J.1
Pao, W.2
Pham, D.3
-
25
-
-
84883378283
-
Association of exon 19 and 21 EGFR mutation patterns with treatment outcome after first-line tyrosine kinase inhibitor in metastatic non-small-cell lung cancer
-
Lee VH, Tin VP, Choy TS, et al. Association of exon 19 and 21 EGFR mutation patterns with treatment outcome after first-line tyrosine kinase inhibitor in metastatic non-small-cell lung cancer. J Thorac Oncol. 2013;8(9):1148-1155.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.9
, pp. 1148-1155
-
-
Lee, V.H.1
Tin, V.P.2
Choy, T.S.3
-
26
-
-
84892631191
-
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
-
Yasuda H, Park E, Yun CH, et al. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med. 2013; 5(216):216-177.
-
(2013)
Sci Transl Med
, vol.5
, Issue.216
, pp. 216-277
-
-
Yasuda, H.1
Park, E.2
Yun, C.H.3
-
27
-
-
12944270589
-
Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction
-
Hall JG, Eis PS, Law SM, et al. Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction. Proc Natl Acad Sci U S A. 2000;97(15):8272-8277.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.15
, pp. 8272-8277
-
-
Hall, J.G.1
Eis, P.S.2
Law, S.M.3
-
28
-
-
23844465454
-
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp
-
Nagai Y, Miyazawa H, Huqun, et al. Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp. Cancer Res. 2005;65(16): 7276-7282.
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7276-7282
-
-
Nagai, Y.1
Miyazawa, H.2
-
29
-
-
33745985181
-
A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
-
Yatabe Y, Hida T, Horio Y, Kosaka T, Takahashi T, Mitsudomi T. A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. J Mol Diagn. 2006;8(3):335-341.
-
(2006)
J Mol Diagn
, vol.8
, Issue.3
, pp. 335-341
-
-
Yatabe, Y.1
Hida, T.2
Horio, Y.3
Kosaka, T.4
Takahashi, T.5
Mitsudomi, T.6
-
30
-
-
33746100318
-
Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer
-
Kimura H, Kasahara K, Kawaishi M, et al. Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer. Clin Cancer Res. 2006;12(13):3915-3921.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.13
, pp. 3915-3921
-
-
Kimura, H.1
Kasahara, K.2
Kawaishi, M.3
-
31
-
-
84868121552
-
An evaluation study of EGFR mutation tests utilized for non-small-cell lung cancer in the diagnostic setting
-
Goto K, Satouchi M, Ishii G, et al. An evaluation study of EGFR mutation tests utilized for non-small-cell lung cancer in the diagnostic setting. Ann Oncol. 2012;23(11):2914-2919.
-
(2012)
Ann Oncol
, vol.23
, Issue.11
, pp. 2914-2919
-
-
Goto, K.1
Satouchi, M.2
Ishii, G.3
-
32
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, Phase III study
-
Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, Phase III study. Lancet Oncol. 2011;12(8):735-742.
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
33
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised Phase III trial
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised Phase III trial. Lancet Oncol. 2012;13(3):239-246.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
34
-
-
84895501505
-
First-line erlotinib versus cisplatin/gemcitabine (GP) in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC): Interim analyses from the Phase III, open-label, ENSURE study
-
Wu YL, Liam CK, Zhou C, et al. First-line erlotinib versus cisplatin/gemcitabine (GP) in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC): interim analyses from the Phase III, open-label, ENSURE study. J Thorac Oncol. 2013;8(Suppl 2):S603.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.SUPPL. 2
-
-
Wu, Y.L.1
Liam, C.K.2
Zhou, C.3
-
35
-
-
84878471164
-
Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a Phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC)
-
Chen G, Feng J, Zhou C, et al. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a Phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol. 2013;24(6):1615-1622.
-
(2013)
Ann Oncol
, vol.24
, Issue.6
, pp. 1615-1622
-
-
Chen, G.1
Feng, J.2
Zhou, C.3
-
36
-
-
84878660120
-
Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations: Results of Lung Oncology Group in Kyushu (LOGiK0803)
-
Yamada K, Takayama K, Kawakami S, et al. Phase II trial of erlotinib for Japanese patients with previously treated non-small-cell lung cancer harboring EGFR mutations: results of Lung Oncology Group in Kyushu (LOGiK0803). Jpn J Clin Oncol. 2013;43(6):629-635.
-
(2013)
Jpn J Clin Oncol
, vol.43
, Issue.6
, pp. 629-635
-
-
Yamada, K.1
Takayama, K.2
Kawakami, S.3
-
37
-
-
84884411444
-
A prospective, Phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC)
-
Goto K, Nishio M, Yamamoto N, et al. A prospective, Phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). Lung Cancer. 2013;82(1):109-114.
-
(2013)
Lung Cancer
, vol.82
, Issue.1
, pp. 109-114
-
-
Goto, K.1
Nishio, M.2
Yamamoto, N.3
-
38
-
-
84905463988
-
Randomized Phase III study comparing gefitinib (G) with erlotinib (E) in patients (pts) with previously treated advanced lung adenocarcinoma (LA): WJOG 5108L [abstract]
-
Katakami N, Morita S, Yoshioka H, et al. Randomized Phase III study comparing gefitinib (G) with erlotinib (E) in patients (pts) with previously treated advanced lung adenocarcinoma (LA): WJOG 5108L [abstract]. J Clin Oncol. 2014;32(Suppl 5):8041.
-
(2014)
J Clin Oncol
, vol.32
, Issue.SUPPL. 5
, pp. 8041
-
-
Katakami, N.1
Morita, S.2
Yoshioka, H.3
-
39
-
-
52049090365
-
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
-
Zhu CQ, da Cunha Santos G, Ding K, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol. 2008;26(26): 4268-4275.
-
(2008)
J Clin Oncol
, vol.26
, Issue.26
, pp. 4268-4275
-
-
Zhu, C.Q.1
da Cunha, S.G.2
Ding, K.3
-
40
-
-
76149100579
-
A Phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705
-
Yoshioka H, Hotta K, Kiura K, et al. A Phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705. J Thorac Oncol. 2010;5(1):99-104.
-
(2010)
J Thorac Oncol
, vol.5
, Issue.1
, pp. 99-104
-
-
Yoshioka, H.1
Hotta, K.2
Kiura, K.3
-
41
-
-
79961071748
-
Phase II study of erlotinib as third-line monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations
-
Matsuura S, Inui N, Ozawa Y, et al. Phase II study of erlotinib as third-line monotherapy in patients with advanced non-small-cell lung cancer without epidermal growth factor receptor mutations. Jpn J Clin Oncol. 2011;41(8):959-963.
-
(2011)
Jpn J Clin Oncol
, vol.41
, Issue.8
, pp. 959-963
-
-
Matsuura, S.1
Inui, N.2
Ozawa, Y.3
-
42
-
-
84880570204
-
Pemetrexed versus erlotinib in pretreated patients with advanced non-small cell lung cancer: A Hellenic Oncology Research Group (HORG) randomized Phase III study
-
Karampeazis A, Voutsina A, Souglakos J, et al. Pemetrexed versus erlotinib in pretreated patients with advanced non-small cell lung cancer: a Hellenic Oncology Research Group (HORG) randomized Phase III study. Cancer. 2013;119(15):2754-2764.
-
(2013)
Cancer
, vol.119
, Issue.15
, pp. 2754-2764
-
-
Karampeazis, A.1
Voutsina, A.2
Souglakos, J.3
-
43
-
-
84885663957
-
Erlotinib in wild type epidermal growth factor receptor non-small cell lung cancer: A systematic review
-
Jazieh AR, Al Sudairy R, Abu-Shraie N, Al Suwairi W, Ferwana M, Murad MH. Erlotinib in wild type epidermal growth factor receptor non-small cell lung cancer: a systematic review. Ann Thorac Med. 2013;8(4):204-208.
-
(2013)
Ann Thorac Med
, vol.8
, Issue.4
, pp. 204-208
-
-
Jazieh, A.R.1
Al-Sudairy, R.2
Abu-Shraie, N.3
Al-Suwairi, W.4
Ferwana, M.5
Murad, M.H.6
-
44
-
-
84883055532
-
Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): A randomised controlled trial
-
Garassino MC, Martelli O, Broggini M, et al. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol. 2013;14(10):981-988.
-
(2013)
Lancet Oncol
, vol.14
, Issue.10
, pp. 981-988
-
-
Garassino, M.C.1
Martelli, O.2
Broggini, M.3
-
45
-
-
84905493900
-
Randomized Phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA)
-
Kawaguchi T, Ando M, Asami K, et al. Randomized Phase III trial of erlotinib versus docetaxel as second- or third-line therapy in patients with advanced non-small-cell lung cancer: Docetaxel and Erlotinib Lung Cancer Trial (DELTA). J Clin Oncol. 2014;32(18):1902-1908.
-
(2014)
J Clin Oncol
, vol.32
, Issue.18
, pp. 1902-1908
-
-
Kawaguchi, T.1
Ando, M.2
Asami, K.3
-
46
-
-
84905449917
-
A Phase II study of erlotinib monotherpay in patients with previously treated advanced non-small cell lung cancer (NSCLC) without EGFR gene mutation who have never/light smoking history: NEJ006/TCOG0903 [abstract]
-
Ishii Y, Maemondo M, Okudera K, et al. A Phase II study of erlotinib monotherpay in patients with previously treated advanced non-small cell lung cancer (NSCLC) without EGFR gene mutation who have never/light smoking history: NEJ006/TCOG0903 [abstract]. J Clin Oncol. 2012;30 Suppl:7561.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
, pp. 7561
-
-
Ishii, Y.1
Maemondo, M.2
Okudera, K.3
-
47
-
-
58149265465
-
Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers
-
Yonesaka K, Zejnullahu K, Lindeman N, et al. Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers. Clin Cancer Res. 2008;14(21): 6963-6973.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.21
, pp. 6963-6973
-
-
Yonesaka, K.1
Zejnullahu, K.2
Lindeman, N.3
-
48
-
-
78650685308
-
Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors
-
Chang MH, Ahn HK, Lee J, et al. Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors. Cancer. 2011;117(1):143-151.
-
(2011)
Cancer
, vol.117
, Issue.1
, pp. 143-151
-
-
Chang, M.H.1
Ahn, H.K.2
Lee, J.3
-
49
-
-
79951911113
-
Plasma transforming growth factor alpha and amphiregulin protein levels in NCIC Clinical Trials Group BR.21
-
Addison CL, Ding K, Zhao H, et al. Plasma transforming growth factor alpha and amphiregulin protein levels in NCIC Clinical Trials Group BR.21. J Clin Oncol. 2010;28(36):5247-5256.
-
(2010)
J Clin Oncol
, vol.28
, Issue.36
, pp. 5247-5256
-
-
Addison, C.L.1
Ding, K.2
Zhao, H.3
-
50
-
-
63049132774
-
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
-
Inoue A, Kobayashi K, Usui K, et al. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol. 2009;27(9):1394-1400.
-
(2009)
J Clin Oncol
, vol.27
, Issue.9
, pp. 1394-1400
-
-
Inoue, A.1
Kobayashi, K.2
Usui, K.3
-
51
-
-
84868192444
-
First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): A double-blind, placebo-controlled, Phase III trial
-
Lee SM, Khan I, Upadhyay S, et al. First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): a double-blind, placebo-controlled, Phase III trial. Lancet Oncol. 2012;13(11):1161-1170.
-
(2012)
Lancet Oncol
, vol.13
, Issue.11
, pp. 1161-1170
-
-
Lee, S.M.1
Khan, I.2
Upadhyay, S.3
-
52
-
-
63849290363
-
Potential treatment options after first-line chemotherapy for advanced NSCLC: Maintenance treatment or early second-line?
-
Gridelli C, Maione P, Rossi A, et al. Potential treatment options after first-line chemotherapy for advanced NSCLC: maintenance treatment or early second-line? Oncologist. 2009;14(2):137-147.
-
(2009)
Oncologist
, vol.14
, Issue.2
, pp. 137-147
-
-
Gridelli, C.1
Maione, P.2
Rossi, A.3
-
53
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355(24):2542-2550.
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
54
-
-
70350225538
-
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, Phase III study
-
Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, Phase III study. Lancet. 2009;374(9699):1432-1440.
-
(2009)
Lancet
, vol.374
, Issue.9699
, pp. 1432-1440
-
-
Ciuleanu, T.1
Brodowicz, T.2
Zielinski, C.3
-
55
-
-
84857507055
-
Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): A double-blind, Phase III, randomised controlled trial
-
Paz-Ares L, de Marinis F, Dediu M, et al. Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, Phase III, randomised controlled trial. Lancet Oncol. 2012;13(3):247-255.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 247-255
-
-
Paz-Ares, L.1
de Marinis, F.2
Dediu, M.3
-
56
-
-
84885924300
-
PARAMOUNT: Final overall survival results of the Phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer
-
Paz-Ares LG, de Marinis F, Dediu M, et al. PARAMOUNT: final overall survival results of the Phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer. J Clin Oncol. 2013;31(23):2895-2902.
-
(2013)
J Clin Oncol
, vol.31
, Issue.23
, pp. 2895-2902
-
-
Paz-Ares, L.G.1
de Marinis, F.2
Dediu, M.3
-
57
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled Phase III study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled Phase III study. Lancet Oncol. 2010;11(6):521-529.
-
(2010)
Lancet Oncol
, vol.11
, Issue.6
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
58
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010;28(2): 357-360.
-
(2010)
J Clin Oncol
, vol.28
, Issue.2
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
-
59
-
-
24944440830
-
TRIBUTE: A Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol. 2005;23(25):5892-5899.
-
(2005)
J Clin Oncol
, vol.23
, Issue.25
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
60
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007;25(12):1545-1552.
-
(2007)
J Clin Oncol
, vol.25
, Issue.12
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
61
-
-
75249084998
-
Randomized, placebo-controlled, Phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer
-
Mok TS, Wu YL, Yu CJ, et al. Randomized, placebo-controlled, Phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol. 2009;27(30): 5080-5087.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5080-5087
-
-
Mok, T.S.1
Wu, Y.L.2
Yu, C.J.3
-
62
-
-
34250637524
-
Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells
-
Li T, Ling YH, Goldman ID, Perez-Soler R. Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res. 2007;13(11):3413-3422.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.11
, pp. 3413-3422
-
-
Li, T.1
Ling, Y.H.2
Goldman, I.D.3
Perez-Soler, R.4
-
63
-
-
84879784343
-
Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): A randomised, double-blind trial
-
Wu YL, Lee JS, Thongprasert S, et al. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Lancet Oncol. 2013;14(8):777-786.
-
(2013)
Lancet Oncol
, vol.14
, Issue.8
, pp. 777-786
-
-
Wu, Y.L.1
Lee, J.S.2
Thongprasert, S.3
-
64
-
-
84915784982
-
Phase II study of gefitinib and inserted cisplatin plus docetaxel as a first-line treatment for advanced non-small cell lung cancer haboring an epidermal growth factor receptor activating mutation [abstract]
-
Kanda S, Ohe Y, Horinouchi H, et al. Phase II study of gefitinib and inserted cisplatin plus docetaxel as a first-line treatment for advanced non-small cell lung cancer haboring an epidermal growth factor receptor activating mutation [abstract]. J Clin Oncol. 2013;31 Suppl:8064.
-
(2013)
J Clin Oncol
, vol.31
, Issue.SUPPL.
, pp. 8064
-
-
Kanda, S.1
Ohe, Y.2
Horinouchi, H.3
-
65
-
-
79957823572
-
Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, Phase III trial
-
Herbst RS, Ansari R, Bustin F, et al. Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, Phase III trial. Lancet. 2011;377(9780):1846-1854.
-
(2011)
Lancet
, vol.377
, Issue.9780
, pp. 1846-1854
-
-
Herbst, R.S.1
Ansari, R.2
Bustin, F.3
-
66
-
-
84905463980
-
Erlotinib plus bevacizumab (EB) versus erlotinib alone (E) as first-line treatment for advanced EGFR mutation-positive nonsquamous non-small cell lung cancer (NSCLC): An open-label randomized trial [abstract]
-
Kato T, Seto T, Nishio M, et al. Erlotinib plus bevacizumab (EB) versus erlotinib alone (E) as first-line treatment for advanced EGFR mutation-positive nonsquamous non-small cell lung cancer (NSCLC): an open-label randomized trial [abstract]. J Clin Oncol. 2014; 32(Suppl 5):8005.
-
(2014)
J Clin Oncol
, vol.32
, Issue.SUPPL. 5
, pp. 8005
-
-
Kato, T.1
Seto, T.2
Nishio, M.3
-
67
-
-
80053531654
-
Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: Implications for clinical trial design
-
Chaft JE, Oxnard GR, Sima CS, Kris MG, Miller VA, Riely GJ. Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: implications for clinical trial design. Clin Cancer Res. 2011;17(19):6298-6303.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.19
, pp. 6298-6303
-
-
Chaft, J.E.1
Oxnard, G.R.2
Sima, C.S.3
Kris, M.G.4
Miller, V.A.5
Riely, G.J.6
-
68
-
-
77249124108
-
Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance
-
Kuo CH, Lin SM, Lee KY, et al. Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance. Clin Lung Cancer. 2010;11(1): 51-56.
-
(2010)
Clin Lung Cancer
, vol.11
, Issue.1
, pp. 51-56
-
-
Kuo, C.H.1
Lin, S.M.2
Lee, K.Y.3
-
69
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
-
Solca F, Dahl G, Zoephel A, et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012;343(2):342-350.
-
(2012)
J Pharmacol Exp Ther
, vol.343
, Issue.2
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
-
70
-
-
77957031745
-
Results from ARQ 197-209: A global randomized placebo-controlled Phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) [abstract]
-
Schiller JH, Akerley WL, Brugger W, et al. Results from ARQ 197-209: a global randomized placebo-controlled Phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2010; 28(Suppl 18):LBA7502.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 18
-
-
Schiller, J.H.1
Akerley, W.L.2
Brugger, W.3
-
71
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]
-
Spigel DR, Ervin TJ, Ramlau R, et al. Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]. J Clin Oncol. 2011;29 Suppl:7505.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
, pp. 7505
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
-
72
-
-
84867901891
-
Epidermal growth factor receptor tyrosine kinase inhibitors beyond progressive disease: A retrospective analysis for Japanese patients with activating EGFR mutations
-
Nishie K, Kawaguchi T, Tamiya A, et al. Epidermal growth factor receptor tyrosine kinase inhibitors beyond progressive disease: a retrospective analysis for Japanese patients with activating EGFR mutations. J Thorac Oncol. 2012;7(11):1722-1727.
-
(2012)
J Thorac Oncol
, vol.7
, Issue.11
, pp. 1722-1727
-
-
Nishie, K.1
Kawaguchi, T.2
Tamiya, A.3
-
73
-
-
84874065941
-
Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors
-
Yu HA, Sima CS, Huang J, et al. Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors. J Thorac Oncol. 2013;8(3):346-351.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.3
, pp. 346-351
-
-
Yu, H.A.1
Sima, C.S.2
Huang, J.3
-
74
-
-
84863892117
-
Randomized Phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
-
Janne PA, Wang X, Socinski MA, et al. Randomized Phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol. 2012;30(17):2063-2069.
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2063-2069
-
-
Janne, P.A.1
Wang, X.2
Socinski, M.A.3
-
75
-
-
79952259564
-
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
-
Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res. 2011;17(5):1169-1180.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.5
, pp. 1169-1180
-
-
Arcila, M.E.1
Oxnard, G.R.2
Nafa, K.3
-
76
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 2013;19(8): 2240-2247.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
77
-
-
84889888266
-
Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: Comparison between T790M mutation-positive and mutation-negative populations
-
Hata A, Katakami N, Yoshioka H, et al. Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: comparison between T790M mutation-positive and mutation-negative populations. Cancer. 2013;119(24): 4325-4332.
-
(2013)
Cancer
, vol.119
, Issue.24
, pp. 4325-4332
-
-
Hata, A.1
Katakami, N.2
Yoshioka, H.3
-
78
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol. 2005;23(3):329-336.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.3
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
-
79
-
-
59449097754
-
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy
-
Kancha RK, von Bubnoff N, Peschel C, Duyster J. Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. Clin Cancer Res. 2009;15(2): 460-467.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.2
, pp. 460-467
-
-
Kancha, R.K.1
von Bubnoff, N.2
Peschel, C.3
Duyster, J.4
-
80
-
-
0043210670
-
FDA drug approval summary: Gefitinib (ZD1839) (Iressa) tablets
-
Cohen MH, Williams GA, Sridhara R, Chen G, Pazdur R. FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist. 2003;8(4):303-306.
-
(2003)
Oncologist
, vol.8
, Issue.4
, pp. 303-306
-
-
Cohen, M.H.1
Williams, G.A.2
Sridhara, R.3
Chen, G.4
Pazdur, R.5
-
81
-
-
24644458654
-
FDA drug approval summary: Erlotinib (Tarceva) tablets
-
Cohen MH, Johnson JR, Chen YF, Sridhara R, Pazdur R. FDA drug approval summary: erlotinib (Tarceva) tablets. Oncologist. 2005;10(7): 461-466.
-
(2005)
Oncologist
, vol.10
, Issue.7
, pp. 461-466
-
-
Cohen, M.H.1
Johnson, J.R.2
Chen, Y.F.3
Sridhara, R.4
Pazdur, R.5
-
82
-
-
0037673681
-
Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ("Iressa", ZD1839) in Japanese patients with solid malignant tumors
-
Nakagawa K, Tamura T, Negoro S, et al. Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ("Iressa", ZD1839) in Japanese patients with solid malignant tumors. Ann Oncol. 2003;14(6):922-930.
-
(2003)
Ann Oncol
, vol.14
, Issue.6
, pp. 922-930
-
-
Nakagawa, K.1
Tamura, T.2
Negoro, S.3
-
83
-
-
37249041552
-
Phase I dose-finding and pharmacokinetic study of the oral epidermal growth factor receptor tyrosine kinase inhibitor Ro50-8231 (erlotinib) in Japanese patients with solid tumors
-
Yamamoto N, Horiike A, Fujisaka Y, et al. Phase I dose-finding and pharmacokinetic study of the oral epidermal growth factor receptor tyrosine kinase inhibitor Ro50-8231 (erlotinib) in Japanese patients with solid tumors. Cancer Chemother Pharmacol. 2008;61(3): 489-496.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, Issue.3
, pp. 489-496
-
-
Yamamoto, N.1
Horiike, A.2
Fujisaka, Y.3
-
84
-
-
33644850757
-
Whole-brain radiotherapy in the management of brain metastasis
-
Khuntia D, Brown P, Li J, Mehta MP. Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol. 2006;24(8): 1295-1304.
-
(2006)
J Clin Oncol
, vol.24
, Issue.8
, pp. 1295-1304
-
-
Khuntia, D.1
Brown, P.2
Li, J.3
Mehta, M.P.4
-
85
-
-
24944474877
-
Current management of brain metastases, with a focus on systemic options
-
Langer CJ, Mehta MP. Current management of brain metastases, with a focus on systemic options. J Clin Oncol. 2005;23(25): 6207-6219.
-
(2005)
J Clin Oncol
, vol.23
, Issue.25
, pp. 6207-6219
-
-
Langer, C.J.1
Mehta, M.P.2
-
86
-
-
84865197331
-
Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation
-
Park SJ, Kim HT, Lee DH, et al. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer. 2012;77(3):556-560.
-
(2012)
Lung Cancer
, vol.77
, Issue.3
, pp. 556-560
-
-
Park, S.J.1
Kim, H.T.2
Lee, D.H.3
-
87
-
-
77954427100
-
Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer
-
Togashi Y, Masago K, Fukudo M, et al. Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer. J Thorac Oncol. 2010;5(7):950-955.
-
(2010)
J Thorac Oncol
, vol.5
, Issue.7
, pp. 950-955
-
-
Togashi, Y.1
Masago, K.2
Fukudo, M.3
-
88
-
-
84866364723
-
Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer
-
Togashi Y, Masago K, Masuda S, et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2012;70(3):399-405.
-
(2012)
Cancer Chemother Pharmacol
, vol.70
, Issue.3
, pp. 399-405
-
-
Togashi, Y.1
Masago, K.2
Masuda, S.3
-
89
-
-
84880923423
-
Erlotinib versus gefitinib for control of leptomeningeal carcinomatosis in non-small-cell lung cancer
-
Lee E, Keam B, Kim DW, et al. Erlotinib versus gefitinib for control of leptomeningeal carcinomatosis in non-small-cell lung cancer. J Thorac Oncol. 2013;8(8):1069-1074.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.8
, pp. 1069-1074
-
-
Lee, E.1
Keam, B.2
Kim, D.W.3
-
90
-
-
18844417090
-
High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib
-
Omuro AM, Kris MG, Miller VA, et al. High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib. Cancer. 2005;103(11): 2344-2348.
-
(2005)
Cancer
, vol.103
, Issue.11
, pp. 2344-2348
-
-
Omuro, A.M.1
Kris, M.G.2
Miller, V.A.3
-
91
-
-
77951951659
-
Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: Pooled analysis
-
Paz-Ares L, Soulieres D, Melezinek I, et al. Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: pooled analysis. J Cell Mol Med. 2010;14(1-2):51-69.
-
(2010)
J Cell Mol Med
, vol.14
, Issue.1-2
, pp. 51-69
-
-
Paz-Ares, L.1
Soulieres, D.2
Melezinek, I.3
-
92
-
-
77956414038
-
Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity
-
Takeda M, Okamoto I, Fukuoka M, Nakagawa K. Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity. J Clin Oncol. 2010;28(17):e273-e274.
-
(2010)
J Clin Oncol
, vol.28
, Issue.17
-
-
Takeda, M.1
Okamoto, I.2
Fukuoka, M.3
Nakagawa, K.4
-
93
-
-
79960128400
-
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: Difference in metabolism as a possible mechanism
-
Kijima T, Shimizu T, Nonen S, et al. Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism. J Clin Oncol. 2011;29(19): e588-e590.
-
(2011)
J Clin Oncol
, vol.29
, Issue.19
-
-
Kijima, T.1
Shimizu, T.2
Nonen, S.3
-
94
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised Phase III trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised Phase III trial. Lancet Oncol. 2010;11(2): 121-128.
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
95
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362(25):2380-2388.
-
(2010)
N Engl J Med
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
96
-
-
80052590374
-
Differences in adverse events between 250 mg daily gefitinib and 150 mg daily erlotinib in Japanese patients with non-small cell lung cancer
-
Togashi Y, Masago K, Fujita S, et al. Differences in adverse events between 250 mg daily gefitinib and 150 mg daily erlotinib in Japanese patients with non-small cell lung cancer. Lung Cancer. 2011;74(1): 98-102.
-
(2011)
Lung Cancer
, vol.74
, Issue.1
, pp. 98-102
-
-
Togashi, Y.1
Masago, K.2
Fujita, S.3
-
97
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566.
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
98
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25): 2385-2394.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
99
-
-
84904692834
-
Overall survival (OS) in patients (pts) with advanced non-small cell lung cancer (NSCLC) harboring common (Del19/L858R) epidermal growth factor receptor mutations (EGFR mut): Pooled analysis of two large open-label Phase III studies (LUX-Lung 3 [LL3] and LUX-Lung 6 [LL6]) comparing afatinib with chemotherapy (CT) [abstract]
-
Yang JC, Sequist LV, Schuler MH, et al. Overall survival (OS) in patients (pts) with advanced non-small cell lung cancer (NSCLC) harboring common (Del19/L858R) epidermal growth factor receptor mutations (EGFR mut): pooled analysis of two large open-label Phase III studies (LUX-Lung 3 [LL3] and LUX-Lung 6 [LL6]) comparing afatinib with chemotherapy (CT) [abstract]. J Clin Oncol. 2014;32(Suppl 5):8004.
-
(2014)
J Clin Oncol
, vol.32
, Issue.SUPPL. 5
, pp. 8004
-
-
Yang, J.C.1
Sequist, L.V.2
Schuler, M.H.3
-
100
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352(8):786-792.
-
(2005)
N Engl J Med
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
101
-
-
84867991219
-
Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation - diversity, ductility, and destiny
-
Suda K, Mizuuchi H, Maehara Y, Mitsudomi T. Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation - diversity, ductility, and destiny. Cancer Metastasis Rev. 2012;31(3-4):807-814.
-
(2012)
Cancer Metastasis Rev
, vol.31
, Issue.3-4
, pp. 807-814
-
-
Suda, K.1
Mizuuchi, H.2
Maehara, Y.3
Mitsudomi, T.4
-
102
-
-
84887111018
-
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: A new era begins
-
Remon J, Moran T, Majem M, et al. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: a new era begins. Cancer Treat Rev. 2014;40(1):93-101.
-
(2014)
Cancer Treat Rev
, vol.40
, Issue.1
, pp. 93-101
-
-
Remon, J.1
Moran, T.2
Majem, M.3
|