Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Kondo, Yuki ^a   Iwao, Takahiro ^a   Yoshihashi, Sachimi ^a   Mimori, Kayo ^a   Ogihara, Ruri ^a   Nagata, Kiyoshi ^b   Kurose, Kouichi ^c   Saito, Masayoshi ^d   Niwa, Takuro ^d,g   Suzuki, Takayoshi ^e   Miyata, Naoki ^a   Ohmori, Shigeru ^f   Nakamura, Katsunori ^a   Matsunaga, Tamihide ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^d MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^f SHINSHU UNIVERSITY   (Japan)

^g Kyowa Hakko Branch   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ALBUMIN; BUTYRIC ACID; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DEXAMETHASONE; DIMETHYL SULFOXIDE; ETHOSUXIMIDE; GABACULINE; GLUCURONOSYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; LIDOCAINE; MESSENGER RNA; NCC 149; NIFEDIPINE; ONCOSTATIN M; PROCAINAMIDE; SCATTER FACTOR; SULFOTRANSFERASE; T 247; UNCLASSIFIED DRUG; VALPROIC ACID; VIGABATRIN; VORINOSTAT; ZONISAMIDE; ALBUMINOID; BIOLOGICAL MARKER; CYTOCHROME P450 3A; MOLECULAR LIBRARY;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; EMBRYO CELL; ENDODERMAL CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LIVER CELL; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; ADULT; AGED; BIOSYNTHESIS; CELL LINE; CELL SHAPE; CYTOLOGY; DRUG EFFECTS; DRUG INACTIVATION; ENZYME INDUCTION; ENZYME SPECIFICITY; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MIDDLE AGED; MOLECULAR LIBRARY; PHARMACOLOGY; STAINING;

ADULT; AGED; ALBUMINS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CELL SHAPE; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTES; HISTONE DEACETYLASE INHIBITORS; HUMANS; INACTIVATION, METABOLIC; INDUCED PLURIPOTENT STEM CELLS; MIDDLE AGED; RNA, MESSENGER; SMALL MOLECULE LIBRARIES; STAINING AND LABELING; SUBSTRATE SPECIFICITY; VALPROIC ACID;

EID: 84905501777     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104010     Document Type: Article

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