Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

Fertility and Sterility

Volumn 102, Issue 2, 2014, Pages 394-398

  Vega, Mario ^a   Breborowicz, Andrzej ^a   Moshier, Erin L ^b   McGovern, Peter G ^a   Keltz, Martin D ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Aneuploidy; assisted reproduction; embryo quality; PGS; preimplantation genetic screening

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; BLASTOCYST; BLASTOMA; BLASTULATION RATE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COHORT ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; EMBRYO; EMBRYO DEVELOPMENT; FERTILIZATION IN VITRO; GENETIC SCREENING; HATCHING; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MALE; PREIMPLANTATION GENETIC SCREENING; PRIORITY JOURNAL; PROBABILITY; RETROSPECTIVE STUDY;

ANEUPLOIDY; ASSISTED REPRODUCTION; EMBRYO QUALITY; PGS; PREIMPLANTATION GENETIC SCREENING;

ADULT; ANEUPLOIDY; BIOPSY; BLASTOCYST; CHROMOSOME ABERRATIONS; CLEAVAGE STAGE, OVUM; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; FERTILIZATION IN VITRO; GENETIC TESTING; HUMANS; LINEAR MODELS; PLOIDIES; PREGNANCY; PREIMPLANTATION DIAGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84905500860     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.04.026     Document Type: Article

References (32)

1. R. Machtinger, and C. Racowsky Morphological systems of human embryo assessment and clinical evidence Reprod Biomed Online 26 2013 210 221
2. M. Montag, J. Liebenthron, and M. Koster Which morphological scoring system is relevant in human embryo development? Placenta 32 Suppl 3 2011 S252 S256
3. M.A. Santos, G. Teklenburg, N.S. Macklon, D. Van Opstal, G.H. Schuring-Blom, and P.J. Krijtenburg et al. The fate of the mosaic embryo: chromosomal constitution and development of day 4, 5 and 8 human embryos Hum Reprod 25 2010 1916 1926
4. M.C. Magli, G.M. Jones, L. Gras, L. Gianaroli, I. Korman, and A.O. Trounson Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro Hum Reprod 15 2000 1781 1786
5. C. Rubio, L. Rodrigo, A. Mercader, E. Mateu, P. Buendia, and T. Pehlivan et al. Impact of chromosomal abnormalities on preimplantation embryo development Prenat Diag 27 2007 748 756
6. S. Alfarawati, E. Fragouli, P. Colls, J. Stevens, C. Gutierrez-Mateo, and W.B. Schoolcraft et al. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender Fertil Steril 95 2011 520 524
7. E.J. Forman, K.M. Upham, M. Cheng, T. Zhao, K.H. Hong, and N.R. Treff et al. Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer Fertil Steril 100 2013 718 724
8. E. Fragouli, M. Lenzi, R. Ross, M. Katz-Jaffe, W.B. Schoolcraft, and D. Wells Comprehensive molecular cytogenetic analysis of the human blastocyst stage Hum Reprod 23 2008 2596 2608
9. A.H. Handyside, J.K. Pattinson, R.J. Penketh, J.D. Delhanty, R.M. Winston, and E.G. Tuddenham Biopsy of human preimplantation embryos and sexing by DNA amplification Lancet 1 1989 347 349
10. Y. Verlinsky, N. Ginsberg, A. Lifchez, J. Valle, J. Moise, and C.M. Strom Analysis of the first polar body: preconception genetic diagnosis Hum Reprod 5 1990 826 829
11. K.A. De Boer, S. McArthur, C. Murray, and R.P.S. Jansen First live birth following blastocyst biopsy and PGD analysis Reprod Biomed Online 4 Suppl 2 2002 35
12. E. Fragouli, and D. Wells Aneuploidy screening for embryo selection Semin Reprod Med 30 2012 289 301
13. M.A. Fritz Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? Hum Reprod 23 2008 2617 2621
14. T. Hardarson, C. Hanson, K. Lundin, T. Hillensjo, L. Nilsson, and J. Stevic et al. Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial Hum Reprod 23 2008 2806 2812
15. S. Mastenbroek, M. Twisk, J. van Echten-Arends, B. Sikkema-Raddatz, J.C. Korevaar, and H.R. Verhoeve et al. In vitro fertilization with preimplantation genetic screening N Engl J Med 357 2007 9 17
16. C. Staessen, P. Platteau, E. Van Assche, A. Michiels, H. Tournaye, and M. Camus et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial Hum Reprod 19 2004 2849 2858
17. L. Werlin, I. Rodi, A. DeCherney, E. Marello, D. Hill, and S. Munne Preimplantation genetic diagnosis as both a therapeutic and diagnostic tool in assisted reproductive technology Fertil Steril 80 2003 467 468
18. S. Evsikov, and Y. Verlinsky Mosaicism in the inner cell mass of human blastocysts Hum Reprod 13 1998 3151 3155
19. M. Li, C.M. DeUgarte, M. Surrey, H. Danzer, A. DeCherney, and D.L. Hill Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3 Fertil Steril 84 2005 1395 1400
20. S. Munné Analysis of chromosome segregation during preimplantation genetic diagnosis in both male and female translocation heterozygotes Cytogenet Genome Res 111 2005 305 309
21. S. Barbash-Hazan, T. Frumkin, M. Malcov, Y. Yaron, T. Cohen, and F. Azem et al. Preimplantation aneuploid embryos undergo self-correction in correlation with their developmental potential Fertil Steril 92 2009 890 896
22. E.B. Baart, D. Van Opstal, F.J. Los, B.C. Fauser, and E. Martini Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5 Hum Reprod 19 2004 685 693
23. N.R. Treff, B. Levy, J. Su, L.E. Northrop, X. Tao, and R.T. Scott Jr. SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH Mol Hum Reprod 16 2010 583 589
24. A. Capalbo, S. Bono, L. Spizzichino, A. Biricik, M. Baldi, and S. Colamaria et al. Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development Hum Reprod 28 2013 509 518
25. C. Gutierrez-Mateo, P. Colls, J. Sanchez-Garcia, T. Escudero, R. Prates, and K. Ketterson et al. Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos Fertil Steril 95 2011 953 958
26. M.D. Keltz, M. Vega, I. Sirota, M. Lederman, E.L. Moshier, and E. Gonzales et al. Preimplantation genetic screening (PGS) with comparative genomic hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages J Assist Reprod Genet 30 2013 1333 1339
27. R.T. Scott Jr., K.M. Upham, E.J. Forman, K.H. Hong, K.L. Scott, and D. Taylor et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial Fertil Steril 100 2013 697 703
28. R.T. Scott Jr., K. Ferry, J. Su, X. Tao, K. Scott, and N.R. Treff Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study Fertil Steril 97 2012 870 875
29. S. Fishel, A. Gordon, C. Lynch, K. Dowell, G. Ndukwe, and E. Kelada et al. Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF? Fertil Steril 93 2010 1006.e7 1006.e10
30. P. Mir, L. Rodrigo, A. Mercader, P. Buendia, E. Mateu, and M. Milan-Sanchez et al. False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3 J Assist Reprod Genet 30 2013 143 149
31. E.J. Forman, K.H. Hong, K.M. Ferry, X. Tao, D. Taylor, and B. Levy et al. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial Fertil Steril 100 2013 100 107.e1
32. R.T. Scott Jr., K.M. Upham, E.J. Forman, T. Zhao, and N.R. Treff Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial Fertil Steril 100 2013 624 630