Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: A prospective randomized controlled trial

Human Reproduction

Volumn 19, Issue 12, 2004, Pages 2849-2858

  Staessen, Catherine ^a   Platteau, Peter ^a   Van Assche, Elvire ^b   Michiels, An ^b   Tournaye, Herman ^a   Camus, Michel ^a   Devroey, Paul ^a   Liebaers, Inge ^b   van Steirteghem, André ^a  

^a CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Age; Aneuploidy screening; FSH; Preimplantation genetic diagnosis; RCT

Indexed keywords

CHORIONIC GONADOTROPIN;

ABORTION; ADULT; AGE DISTRIBUTION; ANEUPLOIDY; ARTICLE; CHROMOSOME 13; CHROMOSOME 16; CHROMOSOME 18; CHROMOSOME 21; CHROMOSOME 22; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIPLOIDY; EMBRYO; EMBRYO TRANSFER; FEMALE; FETUS HEART RATE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC SCREENING; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; MATERNAL AGE; NIDATION; OOCYTE; OUTCOMES RESEARCH; PHASE 3 CLINICAL TRIAL; PRENATAL DIAGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; X CHROMOSOME; Y CHROMOSOME;

EID: 11144305136     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh536     Document Type: Article

References (56)

1. Adonakis G, Camus M, Joris H, Vandervorst M, Van Steirteghem A and Devroey P (1997) The role of the number of replaced embryos on intracytoplasmic sperm injection outcome in women over the age of 40. Hum Reprod 12,2542-2545.
2. Barritt J, Willadsen S, Brenner C and Cohen J (2001) Cytoplasmic transfer in assisted reproduction. Hum Reprod Update 7,428-435.
3. Bielanska M, Tan SL and Ao A (2002) Chromosomal mosaicism throughout human preimplantation development in vitro: incidence, type, and relevance to embryo outcome. Hum Reprod 17,413-419.
4. Claman P, Armant DR, Seibel MM, Wang TA, Oskowitz SP and Taymor ML (1987) The impact of embryo quality and quantity on implantation and the establishment of viable pregnancies. J In Vitro Fertil Embryo Transfer 4,218-222.
5. Clouston HJ, Fenwick J, Webb AL, Herbert M, Murdoch A and Wolstenholme J (1997) Detection of mosaic and non-mosaic chromosome abnormalities in 6- to 8-day-old human blastocysts. Hum Genet 101,30-36.
6. Coonen E, Dumoulin JCM, Ramaekers FCS and Hopman AHN (1994) Optimal preparation of preimplantation embryo interphase nuclei for analysis by fluorescent in situ hybridisation. Hum Reprod 9,533-537.
7. Coonen E, Derhaag JG, Dumoulin JCM, van Wissen LCP, Bras M, Janssen M, Evers JLH and Geraedts JPM (2004) Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos. Hum Reprod 19,316-324.
8. Cummins JM, Breen TM, Harison KL, Shaw JM, Wilson L and Hennessey JF (1986) A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of preembryo quality. J In Vitro Fertil Embryo Transfer 3,284-295.
9. Dailey T, Dale B, Cohen J and Munné S (1996) Association between nondisjunction and maternal age in meiosis-II human oocytes detected by FISH analysis. Am J Hum Genet 59,176-184.
10. Delhanty JDA and Handyside AH (1995) The origin of genetic defects in the human and their detection in the preimplantation embryo. Hum Reprod Update 1,201-215.
11. Evsikov S and Verlinsky Y (1998) Mosaicism in the inner cell mass of human blastocysts. Hum Reprod 13,3151-3155.
12. Gardner DK, Vella P, Lane M, Wagley L, Schlenker T and Schoolcraft WB (1998) Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril 69, 84-99.
13. Gardner DK and Schoolcraft WB (1999) In vitro culture of human blastocyst. In Jansen R and Mortimer D (eds), Towards Reproductive Certainty: Infertility and Genetics Beyond 1999. Parthenon Press, Carnforth, pp. 378-388.
14. Gianaroli L, Magli C, Ferraretti A and Munné S (1999) Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with poor prognosis: identification of the categories for which it should be proposed. Fertil Steril 72,837-844.
15. Giorgetti C, Terriou P, Auquier P, Hans E, Spach JL and Salzmann J (1995) Embryo score to predict implantation after in-vitro fertilization: based on 957 single embryo transfers. Hum Reprod 10,2427-2431.
16. Grimbizis G, Vandervorst M, Camus M, Tournaye H, Van Steirteghem A and Devroey P (1998) Intracytoplasmic sperm injection, results in women older than 39, according to age and the number of embryos replaced in selective or non-selective transfers. Hum Reprod 13,884-889.
17. Hardarson T, Hanson C, Sjögren A and Lundin K (2001) Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation. Hum Reprod 16(2), 313-318.
18. Harper JC, Coonen E, Handyside AH, Winston RM, Hopman AH and Delhanty JD (1995) Mosaicism of autosomes and sex chromosomes in morphologically normal monospermic preimplantation human embryos. Prenat Diagn 15,41-49.
19. Joris H, Nagy Z, Van De Velde H, De Vos A and Van Steirteghem AC (1998) Intracytoplasmic sperm injection: laboratory set-up and injection procedure. Hum Reprod 13 (Suppl 1),76-86.
20. Joris H, De Vos A, Janssens R, Devroey P, Liebaers I and Van Steirteghem A (2003) Comparison of the results of human embryo biopsy and outcome of PGD after zona drilling using acid Tyrode medium or a laser. Hum Reprod 18,1896-1902.
21. Kahraman S, Bahçe M, Samli H, Imirzalioglu N, Yakisn K, Cengiz G and Donmez E (2000) Healthy births and ongoing pregnancies obtained by preimplantation genetic diagnosis in patients with advanced maternal age and recurrent implantation failure. Hum Reprod 15, 2003-2007.
22. Kolibianakis E, Osmanagaoglu K, Camus M, Tournaye H, Van Steirteghem A and Devroey P (2002) Effect of repeated assisted reproductive technology cycles on ovarian response. Fertil Steril 77,967-970.
23. Lamb VK, Yallop K, Clouston HJ, Murdoch AP, Wolstenholme J and Herbert M (2002) Embryo biopsy: to take one cell or two? Hum Reprod 17, Suppl. 1, 96.
24. Laverge H, De Sutter P, Verschraegen-Spae MR, De Paepe A and Dhont M (1997) Triple color fluorescent in situ hybridization for chromosomes X, Y, and 1 on human spare embryos. Hum Reprod 12,809-814.
25. Los FJ, Van Opstal D and van den Berg C (2004) The development of cytogenetically normal, abnormal and mosaic embryos: a theoretical model. Hum Reprod Update 10,79-94.
26. Magli MC, Jones GM, Gras L, Gianaroli L, Korman I and Trounson AO (2000) Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro. Hum Reprod 15, 1781-1786.
27. Magli MC, Gianaroli L and Ferraretti AP (2001) Chromosomal abnormalities in embryos. Mol Cell Endocrinol 183,S29-S34.
28. Marquez C, Sandalinas M, Bahçe M, Alikani M and Munné S (2000) Chromosome abnormalities in 1255 cleavage-stage human embryos. RBM Online 1,17-26.
29. Munné S, Weier RUG, Grifo J and Cohen J (1994) Chromosome mosaicism in human embryos. Biol of Reprod 51,373-379.
30. Munné S, Alikani M, Tomkin G, Grifo J and Cohen J (1995) Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil Steril 64,382-391.
31. Munné S, Magli C, Bahçe M, Fung J, Legator M, Morrison L, Cohert J and Gianaroli L (1998a) Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22. Prenat Diagn 18,1459-1466.
32. Munné S, Marquez C, Reing A, Garrisi J and Alikani M (1998b) Chromosome abnormalities in embryos obtained after conventional in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 69, 904-908.
33. Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, Tucker M, Marquuez C, Sable D, Ferraretti AP, Massey JB and Scott R (1999) Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Hum Reprod 14,2191-2199.
34. Munné S, Sandalinas M, Escudero T, Velilla E, Walmsley R, Sadowy S, Cohen J and Sable D (2003) Improved implantation after preimplantation genetic diagnosis of aneuploidy. RBM Online 7,91-97.
35. Nagy ZP, Dozortsev D, Diamond M, Rienzi L, Ubaldi F, Abdelmassih R and Greco E (2003) Pronuclear morphology evaluation with subsequent evaluation of embryo morphology significantly increases implantation rates. Fertil Steril 80,67-74.
36. Parriego M, Solé M, Vidal F, Boada M, Santalo J, Egozcu J, Viega A and Barri PN (2003) One- or two-cell biopsy: does it affect implantation potential in PGD? Abstractbook TWIN-Meeting Alph-Andrology, 30.
37. Pellicer A, Rubio C, Vidal F, Minguez Y, Egozcue J, Remohi J and Simon C (1999) In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplantation embryos. Fertil Steril 71,1033-1039.
38. Puissant F, Van Rysselberghe M, Barlow P, Deweze J and Leroy F (1987) Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod 2, 705-708.
39. Salumets A, Hyden-Granskog C, Mäkinen S, Suikkari AM, Tiitinen A and Tuuri T (2003) Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures. Hum Reprod 18, 821-825,
40. Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J and Munné S (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Hum Reprod 16,1954-1958.
41. Scott L, Alvero R, Leondires M and Miller B (2000) The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod 15,2394-2403.
42. Simon C, Garcia-Velasco J, Valbuena D, Peinado J, Moreno C, Remohi J and Pellicer A (1998) Increasing uterine receptivity by decreasing estradiol levels during the preimplantational period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil Steril 70, 234-239.
43. Staessen C, Camus M, Bollen, N, Devroey P and Van Steirteghem A (1992) The relationship between embryo quality and the occurrence of multiple pregnancies. Fertil Steril 57,626-630.
44. Staessen C, Nagy ZP, Liu J, Janssenswillen C, Camus M, Devroey P and Van Steirteghem AC (1995) One year's experience with elective transfer of two good quality embryos in the human in-vitro fertilization and intracytoplasmic sperm injection programmes. Hum Reprod 10, 3305-3312.
45. Staessen C, Coonen E, Van Assche E, Tournaye H, Joris H, Devroey P and Van Steirteghem AC (1996) Preimplantation diagnosis for X and Y normality in embryos from three Klinefelter patients. Hum Reprod 11,1650-1653.
46. Staessen C, Van Assche E, Joris H, Bonduelle M, Vandervorst M, Liebaers I and Van Steirteghem A (1999) Clinical experience of sex determination by fluorescent in-situ hybridization for preimplantation genetic diagnosis. Mol Hum Reprod 4,382-389.
47. Staessen C, Tournaye H, Van Assche E, Michiels A, Van Landuyt L, Devroey P, Liebaers I and Van Steirteghem A (2003) PGD in 47,XXY Klinefelter's syndrome patients. Hum Reprod 9,319-330.
48. Staessen C, Michiels A, Devroey P, Liebaers I and Van Steirteghem A (2004) Is it the morphologically best embryo that will implant? Hum Reprod 19 (Suppl 1),i145.
49. Steer CV, Mills CL, Tan SL, Campell S and Edwards RG (1992) The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer program. Hum Reprod 7,117-119.
50. Van de Velde H, De Vos A, Sermon K, Staessen C, De Rycke M, Van Assche E, Lissens W, Vandervorst M, Van Ranst H, Liebaers I et al. (2000) Embryo implantation after biopsy of one or two cells from cleavage-stage embryos with a view to preimplantation genetic diagnosis. Prenat Diagn 20,1030-1037.
51. Van Royen E, Mangelschots K, De Neubourg D, Laureys I, Ryckaert G and Gerris J (2001) Calculating the implantation potential of day 3 embryos in women younger than 38 years of age: a new model. Hum Reprod 16, 326-332.
52. Voullaire L, Slater H, Williamson R and Wilton L (2000) Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization. Hum Genet 106,210-217.
53. Werlin L, Rodi I, DeCherney A, Marello, E, Hill D and Munné S (2003) Preimplantation genetic diagnosis as both a therapeutic and diagnostic tool in assisted reproductive technology. Fertil Steril 80, 467-468.
54. Wilton L (2002) Preimplantation genetic diagnosis for aneuploidy screening in early human embryos: a review. Prenat Diagn 19,846-851.
55. Ziebe S, Petersen K, Lindenberg S, Andersen AG, Gabrielsen A and Nyboe Andersen A (1997) Embryo morphology or cleavage stage: how to select the best embryos for transfer after in vitro fertilization. Hum Reprod 12, 1545-1549.
56. Ziebe S, Lundin K, Loft A, Bergh C, Nyboe Andersen A, Selleskog U, Nielsen D, Grondahl C, Kim H and Arce JCP (2003) FISH analysis for chromosomes 13, 16, 18, 22, X and Y in all blastomeres of IVF pre-embryos from 144 randomly selected human oocytes and impact on pre-embryo morphology. Hum Reprod 18,2575-2581.