Preimplantation Genetic Screening (PGS) with Comparative Genomic Hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages

Journal of Assisted Reproduction and Genetics

Volumn 30, Issue 10, 2013, Pages 1333-1339

  Keltz, Martin D ^a,c   Vega, Mario ^a   Sirota, Ido ^a   Lederman, Matthew ^a   Moshier, Erin L ^b   Gonzales, Eric ^a   Stein, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Aneuploidy; Blastomere biopsy; Comparative genomic hybridization; Preimplantation genetic screening

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL INSEMINATION; BLASTOMA; CASE CONTROL STUDY; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GENETIC SCREENING; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; MULTIPLE PREGNANCY; OOCYTE CLEAVAGE; OOCYTE RETRIEVAL; PREGNANCY OUTCOME; PREGNANCY RATE; PREIMPLANTATION GENETIC SCREENING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE CELL ANALYSIS; SPONTANEOUS ABORTION; TETRAPLOIDY; TUMOR BIOPSY;

ABORTION, SPONTANEOUS; ADULT; BLASTOMERES; CASE-CONTROL STUDIES; COMPARATIVE GENOMIC HYBRIDIZATION; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMANS; LIVE BIRTH; PREGNANCY; PREGNANCY RATE; PREGNANCY, MULTIPLE; PREIMPLANTATION DIAGNOSIS; RETROSPECTIVE STUDIES;

EID: 84887996263     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-013-0070-6     Document Type: Article

References (39)

1. Assou S, Haouzi D, De Vos J, Hamamah S. Human cumulus cells as biomarkers for embryo and pregnancy outcomes. Mol Hum Reprod. 2010;16(8):531-8.
2. Brison DR, Houghton FD, Falconer D, Roberts SA, Hawkhead J, Humpherson PG, et al. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod. 2004;19(10):2319-24.
3. Capalbo A, Bono S, Spizzichino L, Biricik A, Baldi M, Colamaria S, et al. Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development. Hum Reprod. 2013;28(2):509-18.
4. Cruz M, Gadea B, Garrido N, Pedersen KS, Martínez M, Pérez-Cano I, et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J Assist Reprod Genet. 2011;28(7):569-73.
5. Delhanty JD, Griffin DK, Handyside AH, Harper J, Atkinson GH, Pieters MH, et al. Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation, (FISH). Hum Mol Genet. 1993;2(8):1183-5.
6. Drugan A, Koppitch 3rd FC, Williams 3rd JC, Johnson MP, Moghissi KS, Evans MI. Prenatal genetic diagnosis following recurrent early pregnancy loss. Obstet Gynecol. 1990;75(3 Pt 1):381-4.
7. Fauser BC. Screening of embryos for numerical chromosome abnormalities during in-vitro fertilisation is not useful for application in daily practice. Ned Tijdschr Geneeskd. 2008;152(13):734-6.
8. Fishel S, Gordon A, Lynch C, Dowell K, Ndukwe G, Kelada E, et al. Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF? Fertil Steril. 2010;93(3):1006.e1007-10.
9. Fragouli E, Wells D. Aneuploidy screening for embryo selection. Semin Reprod Med. 2012;30(4):289-301.
10. Fritz MA. Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? Hum Reprod. 2008;23(12):2617-21.
11. Hardarson T, Hanson C, Lundin K, Hillensjo T, Nilsson L, Stevic J, et al. Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial. Hum Reprod. 2008;23(12):2806-12.
12. Harper J, Coonen E, De Rycke M, Fiorentino F, Geraedts J, Goossens V, et al. What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium Steering Committee. Hum Reprod. 2010;25(4):821-3.
13. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2(4):280-91.
14. Hodes-Wertz B, Grifo J, Ghadir S, Kaplan B, Laskin CA, Glassner M, et al. Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos. Fertil Steril. 2012;98(3):675-80.
15. Huang JY, Rosenwaks Z. In vitro fertilisation treatment and factors affecting success. Best Pract Res Clin Obstet Gynaecol. 2012;26(6):777-88.
16. Kamiguchi Y, Rosenbusch B, Sterzik K, Mikamo K. Chromosomal analysis of unfertilized human oocytes prepared by a gradual fixation-air drying method. Hum Genet. 1993;90(5):533-41.
17. Katz-Jaffe MG, McReynolds S, Gardner DK, Schoolcraft WB. The role of proteomics in defining the human embryonic secretome. Mol Hum Reprod. 2009;15(5):271-7.
18. Katz-Jaffe MG, Schoolcraft WB, Gardner DK. Analysis of protein expression (secretome) by human and mouse preimplantation embryos. Fertil Steril. 2006;86(3):678-85.
19. Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online. 2008;17(3):385-91.
20. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007;357(1):9-17.
21. Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A. Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study. Fertil Steril. 2012;98(6):1481-1489.e1410.
22. Munne S, S ES, Grifo J, Marut E, Opsahl M and Taylor TH "Preimplantation genetic diagnosis using a-CGH significantly increases ongoing pregnancy rates per transfer." Fertil Steril 2010; 94(S81).
23. Munne S, Lee A, Rosenwaks Z, Grifo J, Cohen J. Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod. 1993;8(12):2185-91.
24. Palermo GD, Munne S, Colombero LT, Cohen J, Rosenwaks Z. Genetics of abnormal human fertilization. Hum Reprod. 1995;10 Suppl 1:120-7.
25. Pribenszky C, Losonczi E, Molnár M, Lang Z, Mátyás S, Rajczy K, et al. Prediction of in-vitro developmental competence of early cleavage-stage mouse embryos with compact time-lapse equipment. Reprod Biomed Online. 2010;20(3):371-9.
26. Pribenszky C, Mátyás S, Kovács P, Losonczi E, Zádori J, Vajta G. Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring. Reprod Biomed Online. 2010;21(4):533-6.
27. Rabinowitz A, Beltsos A, D Potter, Bush M, Givens C and D Smotrich. "Effects of advanced maternal age are abrogated in 122 patients undergoing transfer of embryos with euploid microarray screening results at cleavage stage." Fertil Steril 2010;94(S80).
28. Rubio C, Simón C, Vidal F, Rodrigo L, Pehlivan T, Remohí J, et al. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum Reprod. 2003;18(1):182-8.
29. Schoolcraft WB, Katz-Jaffe MG, Stevens J, Rawlins M, Munne S. Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial. Fertil Steril. 2009;92(1):157-62.
30. Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertil Steril. 2008;90(1):77-83.
31. Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril. 2007;88(5):1350-7.
32. Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, et al. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertil Steril. 2010;94(2):535-42.
33. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod. 2004;19(12):2849-58.
34. Staessen C, Verpoest W, Donoso P, Haentjens P, Van der Elst J, Liebaers I, et al. Preimplantation genetic screening does not improve delivery rate in women under the age of 36 following single-embryo transfer. Hum Reprod. 2008;23(12):2818-25.
35. Treff NR, Levy B, Su J, Northrop LE, Tao X, Scott Jr RT. SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH. Mol Hum Reprod. 2010;16(8):583-9.
36. Twisk M, Mastenbroek S, Hoek A, Heineman MJ, van der Veen F, Bossuyt PM, et al. No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy. Hum Reprod. 2008;23(12):2813-7.
37. Voullaire L, Wilton L, McBain J, Callaghan T, Williamson R. Chromosome abnormalities identified by comparative genomic hybridization in embryos from women with repeated implantation failure. Mol Hum Reprod. 2002;8(11):1035-41.
38. Wells D, Delhanty JD. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol Hum Reprod. 2000;6(11):1055-62.
39. Wilton L, Voullaire L, Sargeant P, Williamson R, McBain J. Preimplantation aneuploidy screening using comparative genomic hybridization or fluorescence in situ hybridization of embryos from patients with recurrent implantation failure. Fertil Steril. 2003;80(4):860-8.