Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats

Experimental Neurology

Volumn 261, Issue , 2014, Pages 396-403

  Fujii, Mutsumi ^a   Sherchan, Prativa ^a   Soejima, Yoshiteru ^a   Hasegawa, Yu ^a   Flores, Jerry ^a   Doycheva, Desislava ^a   Zhang, John H ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

Apoptosis; Brain edema; Cannabinoid receptor type 2; CREB; JWH133; Subarachnoid hemorrhage

Indexed keywords

1,1-DIMETHYLBUTYL-1-DEOXY-DELTA(9)-THC; CANNABINOID; CANNABINOID 2 RECEPTOR; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ENZYME INHIBITOR; PROTEIN BCL 2; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SMALL INTERFERING RNA;

AGONISTS; ANIMAL; APOPTOSIS; BRAIN INJURIES; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; MALE; METABOLISM; PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SUBARACHNOID HEMORRHAGE; TIME; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INJURY; BRAIN WATER; CONTROLLED STUDY; DRUG MECHANISM; EARLY BRAIN INJURY; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CANNABINOIDS; CASPASE 3; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; MALE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TIME FACTORS;

EID: 84905483117     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.07.005     Document Type: Article

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