A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach

PLoS Genetics

Volumn 10, Issue 7, 2014, Pages

  Traylor, Matthew ^a   Mäkelä, Kari Matti ^b,c   Kilarski, Laura L ^a   Holliday, Elizabeth G ^d,e   Devan, William J ^f,g   Nalls, Mike A ^h   Wiggins, Kerri L ⁱ   Zhao, Wei ^j   Cheng, Yu Ching ^k,l   Achterberg, Sefanja ^m   Malik, Rainer ⁿ   Sudlow, Cathie ^o   Bevan, Steve ^p   Raitoharju, Emma ^b,c   Oksala, Niku ^b,c,q   Thijs, Vincent ^r,s,t   Lemmens, Robin ^r,s,t   Lindgren, Arne ^u,v   Slowik, Agnieszka ^w   Maguire, Jane M ^d,e,x,y   Walters, Matthew ^z   Algra, Ale ^m   Sharma, Pankaj ^aa   Attia, John R ^d,e,y   Boncoraglio, Giorgio B ^ab   Rothwell, Peter M ^ac   de Bakker, Paul I W ^g,m,ad   Bis, Joshua C ⁱ   Saleheen, Danish ^ae,af   Kittner, Steven J ^l   Mitchell, Braxton D ^k   Rosand, Jonathan ^f,g   Meschia, James F ^ag   Levi, Christopher ^e,y   Dichgans, Martin ^n,ah   Lehtimäki, Terho ^b,c   Lewis, Cathryn M ^ai   Markus, Hugh S ^p   more..

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b FIMLAB LABORATORIES   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF NEWCASTLE   (Australia)

^e HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h NATIONAL INSTITUTE ON AGING   (United States)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF PENNSYLVANIA   (United States)

^k UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^l VETERANS AFFAIRS MEDICAL CENTER   (United States)

^m UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

ⁿ LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^o UNIVERSITY OF EDINBURGH   (United Kingdom)

^p UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^q TAMPERE UNIVERSITY HOSPITAL   (Finland)

^r KU LEUVEN UNIVERSITY OF LEUVEN   (Belgium)

^s DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^t UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^u LUND UNIVERSITY   (Sweden)

^v LUND UNIVERSITY HOSPITAL   (Sweden)

^w JAGIELLONIAN UNIVERSITY   (Poland)

^x UNIVERSITY OF NEWCASTLE   (Australia)

^y UNIVERSITY OF NEWCASTLE   (Australia)

^z UNIVERSITY OF GLASGOW   (United Kingdom)

^aa IMPERIAL COLLEGE LONDON   (United Kingdom)

^ab NATIONAL CANCER INSTITUTE   (Italy)

^ac UNIVERSITY OF OXFORD   (United Kingdom)

^ad BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ae UNIVERSITY OF PENNSYLVANIA   (United States)

^af Center for Non Communicable Diseases   (Pakistan)

^ag MAYO CLINIC   (United States)

^ah Germany 3 Munich Cluster for Systems Neurology   (Germany)

^ai KING'S COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MACROPHAGE ELASTASE; MESSENGER RNA; GLYCOSAMINOGLYCAN; MMP12 PROTEIN, HUMAN; SULODEXIDE;

ADULT; AGED; ARTICLE; BRAIN ATHEROSCLEROSIS; BRAIN ISCHEMIA; CARDIOEMBOLIC STROKE; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MMP12 GENE; ONSET AGE; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; ARTERY; CLASSIFICATION; CORONARY ARTERY DISEASE; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HEART INFARCTION; MALE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; AGE OF ONSET; AGED; ARTERIES; CORONARY ARTERY DISEASE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GLYCOSAMINOGLYCANS; HUMANS; MALE; MATRIX METALLOPROTEINASE 12; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84905454842     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004469     Document Type: Article

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