SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C

Neuropharmacology

Volumn 86, Issue , 2014, Pages 145-154

  Lee, Sang Min ^a   Kant, Andrew ^b   Blake, Daniel ^a   Murthy, Vishakantha ^a   Boyd, Kevin ^a   Wyrick, Steven J ^b   Mailman, Richard B ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenylate cyclase; Functional selectivity; Ligand bias; Partial agonist; Phospholipase C; Rat striatum; SKF 83959

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; ADENYLATE CYCLASE; BENZAZEPINE DERIVATIVE; BETA ARRESTIN; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DRUG METABOLITE; PHOSPHOLIPASE C; DOPAMINE RECEPTOR STIMULATING AGENT; RETINA S ANTIGEN; SK&F 83959;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; EX VIVO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRINSIC ACTIVITY; PARTIAL AGONISM; PROTEIN EXPRESSION; PROTEIN INTERACTION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENETIC TRANSFECTION; HEK293 CELL LINE; METABOLISM; SPRAGUE DAWLEY RAT;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ADENYLYL CYCLASES; ANIMALS; ARRESTINS; BRAIN; CHO CELLS; CRICETULUS; DOPAMINE AGENTS; HEK293 CELLS; HUMANS; MALE; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; TRANSFECTION; TYPE C PHOSPHOLIPASES;

EID: 84905404802     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.05.042     Document Type: Article

References (84)

1. G. Andringa, J.C. Stoof, and A.R. Cools Sub-chronic administration of the dopamine D(1) antagonist SKF 83959 in bilaterally MPTP-treated rhesus monkeys: stable therapeutic effects and wearing-off dyskinesia Psychopharmacol. Berl. 146 1999 328 334 (Pubitemid 29480245)
2. A.F. Arnsten, J.X. Cai, B.L. Murphy, and P.S. Goldman-Rakic Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys Psychopharmacol 116 1994 143 151 (Pubitemid 24317040)
3. J. Arnt, J. Hyttel, and C. Sanchez Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro Eur. J. Pharmacol. 213 1992 259 267
4. 1 receptor stimulation on rotation and c-fos expression Eur. J. Pharmacol. 235 1993 167 168 (Pubitemid 23124089)
5. I. Aubert, I. Ghorayeb, E. Normand, and B. Bloch Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum J. Comp. Neurol. 418 2000 22 32 (Pubitemid 30090937)
6. A.A. Banday, and M.F. Lokhandwala Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2 Am. J. Physiol. Ren. Physiol. 293 2007 F306 F315
7. P.J. Blanchet, J. Fang, M. Gillespie, L. Sabounjian, K.W. Locke, R. Gammans, M.M. Mouradian, and T.N. Chase Effects of the full dopamine D1 receptor agonist dihydrexidine in Parkinson's disease Clin. Neuropharmacol. 21 1998 339 343 (Pubitemid 28543948)
8. J.T. Brown, A. Kant, and R.B. Mailman Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: application in GPCR-mediated adenylate cyclase assays J. Neurosci. Methods 177 2009 261 266
9. K.D. Burris, T.F. Molski, C. Xu, E. Ryan, K. Tottori, T. Kikuchi, F.D. Yocca, and P.B. Molinoff Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors J. Pharmacol. Exp. Ther. 302 2002 381 389 (Pubitemid 34680462)
10. B.R. Chemel, L.A. Bonner, V.J. Watts, and D.E. Nichols Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D1 receptor catechol agonists Mol. Pharmacol. 81 2012 729 738
11. K. Cheng, S. Khurana, Y. Chen, R.H. Kennedy, P. Zimniak, and J.P. Raufman Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist J. Pharmacol. Exp. Ther. 303 2002 29 35
12. L.S. Chun, R.B. Free, T.B. Doyle, X.P. Huang, M.L. Rankin, and D.R. Sibley D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms Mol. Pharmacol. 84 2013 190 200
13. A.M. Deveney, and J.L. Waddington Pharmacological characterization of behavioural responses to SK&F 83959 in relation to 'D1-like' dopamine receptors not linked to adenylyl cyclase Br. J. Pharmacol. 116 1995 2120 2126
14. R.P. Downes, and J.L. Waddington Grooming and vacuous chewing induced by SK&F 83959, an agonist of dopamine 'D1-like' receptors that inhibits dopamine-sensitive adenylyl cyclase Eur. J. Pharmacol. 234 1993 135 136 (Pubitemid 23093417)
15. L.E. Dyck Effects of dopamine on phosphoinositide hydrolysis in slices of rat striatum and cortex Neurochem Int. 17 1990 77 82 (Pubitemid 20224180)
16. C.C. Felder, M. Blecher, and P.A. Jose Dopamine-1-mediated stimulation of phospholipase C activity in rat renal cortical membranes J. Biol. Chem. 264 1989 8739 8745 (Pubitemid 19151593)
17. C.C. Felder, P.A. Jose, and J. Axelrod The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase J. Pharmacol. Exp. Ther. 248 1989 171 175 (Pubitemid 19063485)
18. E. Friedman, L.Q. Jin, G.P. Cai, T.R. Hollon, J. Drago, D.R. Sibley, and H.Y. Wang D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice Mol. Pharmacol. 51 1997 6 11 (Pubitemid 27049539)
19. S. Fujita, M. Kiguchi, M. Kobayashi, A. Kinsella, N. Koshikawa, and J.L. Waddington Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959 Eur. J. Pharmacol. 632 2010 39 44
20. R.R. Gainetdinov, R.T. Premont, L.M. Bohn, R.J. Lefkowitz, and M.G. Caron Desensitization of G protein-coupled receptors and neuronal functions Annu Rev. Neurosci. 27 2004 107 144 (Pubitemid 39050399)
21. C.R. Gerfen, T.M. Engber, L.C. Mahan, Z. Susel, T.N. Chase, F.J. Monsma Jr., and D.R. Sibley D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons [see comments] Science 250 1990 1429 1432 (Pubitemid 120031867)
22. 1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset Psychopharmacol 117 1995 275 286
23. K.K. Gnanalingham, A.J. Hunter, P. Jenner, and C.D. Marsden Stimulation of adenylate cyclase activity by benzazepine D-1 dopamine agonists with varying efficacies in the 6-hydroxydopamine lesioned rat-relationship to circling behaviour Biochem Pharmacol. 49 1995 1185 1193
24. 1 dopamine receptor agonist in a rat model of Parkinson's disease J. Pharmacol. Exp. Ther. 296 2001 338 344 (Pubitemid 32112458)
25. L. Guo, J. Zhao, G. Jin, B. Zhao, G. Wang, A. Zhang, and X. Zhen SKF83959 is a Potent allosteric modulator of sigma-1 receptor Mol. Pharmacol. 83 2013 577 586
26. J.F. Harper, and G. Brooker Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution J. Cycl. Nucleotide Res. 1 1975 207 218
27. A. Hasbi, T. Fan, M. Alijaniaram, T. Nguyen, M.L. Perreault, B.F. O'Dowd, and S.R. George Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth Proc. Natl. Acad. Sci. U. S. A. 106 2009 21377 21382
28. A. Hasbi, B.F. O'Dowd, and S.R. George Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance Mol. Brain 4 2011 26
29. T.G. Heffner, J.A. Hartman, and L.S. Seiden A rapid method for the regional dissection of the rat brain Pharmacol. Biochem Behav. 13 1980 453 456 (Pubitemid 10008987)
30. J. Jakubik, L. Bacakova, E.E. el-Fakahany, and S. Tucek Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors Mol. Pharmacol. 52 1997 172 179 (Pubitemid 27318633)
31. 1 dopamine receptors in rat brain J. Neurochem 85 2003 378 386 (Pubitemid 36438333)
32. T. Kenakin Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors Trends Pharmacol. Sci. 28 2007 407 415 (Pubitemid 47087972)
33. T. Kikuchi, K. Tottori, Y. Uwahodo, T. Hirose, T. Miwa, Y. Oshiro, and S. Morita 7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)- qui nolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity J. Pharmacol. Exp. Ther. 274 1995 329 336
34. C.P. Lawler, C. Prioleau, M.M. Lewis, C. Mak, D. Jiang, J.A. Schetz, A.M. Gonzalez, D.R. Sibley, and R.B. Mailman Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes Neuropsychopharmacology 20 1999 612 627 (Pubitemid 29189265)
35. C. Le Moine, and B. Bloch D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum J. Comp. Neurol. 355 1995 418 426
36. S.P. Lee, C.H. So, A.J. Rashid, G. Varghese, R. Cheng, A.J. Lanca, B.F. O'Dowd, and S.R. George Dopamine D1 and D2 receptor co-activation generates a novel phospholipase C-mediated calcium signal J. Biol. Chem. 279 2004 35671 35678 (Pubitemid 39100570)
37. M.S. Lidow, and P.S. Goldman-Rakic A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex Proc. Natl. Acad. Sci. U. S. A. 91 1994 4353 4356
38. J. Liu, F. Wang, C. Huang, L.H. Long, W.N. Wu, F. Cai, J.H. Wang, L.Q. Ma, and J.G. Chen Activation of phosphatidylinositol-linked novel D1 dopamine receptor contributes to the calcium mobilization in cultured rat prefrontal cortical astrocytes Cell. Mol. Neurobiol. 29 2009 317 328
39. J. Liu, W. Wang, F. Wang, F. Cai, Z.L. Hu, Y.J. Yang, J. Chen, and J.G. Chen Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses Neuropharmacology 57 2009 164 171
40. 2+ mobilization in Xenopus oocytes Proc. Natl. Acad. Sci. U. S. A. 87 1990 2196 2200
41. R. Mailman, X. Huang, and D.E. Nichols Parkinson's disease and D1 dopamine receptors Curr. Opin. Investig. Drugs 2 2001 1582 1591
42. R.B. Mailman GPCR functional selectivity has therapeutic impact Trends Pharmacol. Sci. 28 2007 390 396 (Pubitemid 47087963)
43. R.B. Mailman, and V. Murthy Third generation antipsychotic drugs: partial agonism or receptor functional selectivity? Curr. Pharm. Des. 16 2010 488 501
44. R.B. Mailman, D.E. Nichols, M.M. Lewis, B.L. Blake, and C.P. Lawler Functional effects of novel dopamine ligands: dihydrexidine and Parkinson's Disease as a first step P. Jenner, R. Demirdemar, Dopamine Receptor Subtypes: From Basic Science to Clinical Application 1998 IOS Stockton Press Amsterdam 64 83
45. K. Mizuno, K. Kurokawa, and S. Ohkuma Dopamine D1 receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via both AP-1- and NFATc4-mediated transcriptional processes J. Neurochem. 122 2012 702 713
46. J.L. Neumeyer, N.S. Kula, J. Bergman, and R.J. Baldessarini Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines Eur. J. Pharmacol. 474 2003 137 140 (Pubitemid 37281441)
47. K.A. Neve Functional Selectivity of G Protein-Coupled Receptor Ligands 2009 Humana New York
48. K.A. Neve, J.K. Seamans, and H. Trantham-Davidson Dopamine receptor signaling J. Rec. Sign Transd Res. 24 2004 165 205 (Pubitemid 39332216)
49. G.J. O'Sullivan, B.L. Roth, A. Kinsella, and J.L. Waddington SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography Eur. J. Pharmacol. 486 2004 273 280 (Pubitemid 38231057)
50. M.A. Pacheco, and R.S. Jope Comparison of [3H]phosphatidylinositol and [3H]phosphatidylinositol 4,5- bisphosphate hydrolysis in postmortem human brain membranes and characterization of stimulation by dopamine D1 receptors J. Neurochem. 69 1997 639 644 (Pubitemid 27327965)
51. S. Panchalingam, and A.S. Undie SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain Neuropharmacology 40 2001 826 837 (Pubitemid 32436459)
52. M.L. Perreault, A. Hasbi, M. Alijaniaram, T. Fan, G. Varghese, P.J. Fletcher, P. Seeman, B.F. O'Dowd, and S.R. George The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia J. Biol. Chem. 285 2010 36625 36634
53. M.L. Perreault, A. Hasbi, B.F. O'Dowd, and S.R. George The dopamine D1-D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia Front. Neuroanat. 5 2011 31
54. M.L. Perreault, A. Hasbi, B.F. O'Dowd, and S.R. George Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance Neuropsychopharmacology 39 2014 156 168
55. O. Rascol, O. Blin, C. Thalamas, S. Descombes, C. Soubrouillard, P. Azulay, N. Fabre, F. Viallet, K. Lafnitzegger, S. Wright, J.H. Carter, and J.G. Nutt ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease Ann. Neurol. 45 1999 736 741 (Pubitemid 29260750)
56. A.J. Rashid, B.F. O'Dowd, V. Verma, and S.R. George Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine Trends Pharmacol. Sci. 28 2007 551 555 (Pubitemid 350026611)
57. A.J. Rashid, C.H. So, M.M. Kong, T. Furtak, M. El-Ghundi, R. Cheng, B.F. O'Dowd, and S.R. George D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum Proc. Natl. Acad. Sci. U. S. A. 104 2007 654 659 (Pubitemid 46123080)
58. 1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder Neuropsychopharmacol 2014 (in press)
59. J.P. Ryman-Rasmussen, D.E. Nichols, and R.B. Mailman Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists Mol. Pharmacol. 68 2005 1039 1048 (Pubitemid 41345795)
60. J.S. Schneider, Z.Q. Sun, and D.P. Roeltgen Effects of dihydrexidine, a full dopamine D-1 receptor agonist, on delayed response performance in chronic low dose MPTP-treated monkeys Brain Res. 663 1994 140 144 (Pubitemid 24329674)
61. P.E. Setler, H.M. Sarau, C.L. Zirkle, and H.L. Saunders The central effects of a novel dopamine agonist Eur. J. Pharmacol. 50 1978 419 430 (Pubitemid 9212897)
62. D.A. Shapiro, S. Renock, E. Arrington, D.R. Sibley, L.A. Chiodo, B.L. Roth, and R.B. Mailman Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology Neuropsychopharmacology 28 2003 1400 1411 (Pubitemid 41070874)
63. S.K. Shenoy, and R.J. Lefkowitz Seven-transmembrane receptor signaling through beta-arrestin Sci. STKE 2005 cm10
64. M.S. Starr The role of dopamine in epilepsy Synapse 22 1996 159 194 (Pubitemid 26041233)
65. T.D. Steele, D.B. Hodges Jr., T.R. Levesque, and K.W. Locke D1 agonist dihydrexidine releases acetylcholine and improves cognitive performance in rats Pharmacol. Biochem Behav. 58 1997 477 483 (Pubitemid 27394301)
66. T.D. Steele, D.B. Hodges Jr., T.R. Levesque, K.W. Locke, and B.W. Sandage Jr. The D1 agonist dihydrexidine releases acetylcholine and improves cognition in rats Ann. N. Y. Acad. Sci. 777 1996 427 430 (Pubitemid 26149225)
67. J.R. Taylor, M.S. Lawrence, D.E. Redmond Jr., J.D. Elsworth, R.H. Roth, D.E. Nichols, and R.B. Mailman Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys Eur. J. Pharmacol. 199 1991 389 391
68. D. Thibault, F. Loustalot, G.M. Fortin, M.J. Bourque, and L.E. Trudeau Evaluation of D1 and D2 dopamine receptor segregation in the developing striatum using BAC transgenic mice PLoS One 8 2013 e67219
69. 1 receptor enhances inositol phosphates formation in rat brain J. Pharmacol. Exp. Ther. 253 1990 987 992 (Pubitemid 20209354)
70. A.S. Undie, and E. Friedman Selective dopaminergic mechanism of dopamine and SKF38393 stimulation of inositol phosphate formation in rat brain Eur. J. Pharmacol. 226 1992 297 302
71. A.S. Undie, and E. Friedman Inhibition of dopamine agonist-induced phosphoinositide hydrolysis by concomitant stimulation of cyclic AMP formation in brain slices J. Neurochem. 63 1994 222 230 (Pubitemid 24184922)
72. 1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain J. Neurochem. 62 1994 2045 2048
73. J.D. Urban, W.P. Clarke, M. von Zastrow, D.E. Nichols, B. Kobilka, H. Weinstein, J.A. Javitch, B.L. Roth, A. Christopoulos, P.M. Sexton, K.J. Miller, M. Spedding, and R.B. Mailman Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320 2007 1 13 (Pubitemid 46025713)
74. N.M. Urs, T.L. Daigle, and M.G. Caron A dopamine D1 receptor-dependent beta-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice Neuropsychopharmacology 36 2011 551 558
75. S.J. Vyas, J. Eichberg, and M.F. Lokhandwala Characterization of receptors involved in dopamine-induced activation of phospholipase-C in rat renal cortex J. Pharmacol. Exp. Ther. 260 1992 134 139
76. V.J. Watts, C.P. Lawler, J.H. Gilmore, S.B. Southerland, D.E. Nichols, and R.B. Mailman Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents Eur. J. Pharmacol. 242 1993 165 172 (Pubitemid 23288795)
77. V.J. Watts, C.P. Lawler, A.J. Gonzales, Q.Y. Zhou, O. Civelli, D.E. Nichols, and R.B. Mailman Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists Synapse 21 1995 177 187
78. J. Weinstock, J.P. Hieble, and J.W. Wilson The chemistry and pharmacology of 3-benzazepine derivatives Drugs Future 10 1985 645 696
79. M.D. Wood, K.L. Murkitt, M. Ho, J.M. Watson, F. Brown, A.J. Hunter, and D.N. Middlemiss Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry Br. J. Pharmacol. 126 1999 1620 1624 (Pubitemid 29182346)
80. Y. Yu, J.R. Wang, P.H. Sun, Y. Guo, Z.J. Zhang, G.Z. Jin, and X. Zhen Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action J. Neurochem. 104 2008 946 956 (Pubitemid 351146579)
81. H. Zhang, L. Ma, F. Wang, J. Chen, and X. Zhen Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease Neuropharmacology 53 2007 125 133 (Pubitemid 47125943)
82. 2+ signaling J. Neurosci. 29 2009 7766 7775
83. Z.J. Zhang, X.L. Jiang, S.E. Zhang, C.J. Hough, H. Li, J.G. Chen, and X.C. Zhen The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm Neurosci. Lett. 382 2005 134 138 (Pubitemid 40725880)
84. X. Zhen, S. Goswami, and E. Friedman The role of the phosphatidyinositol- linked D1 dopamine receptor in the pharmacology of SKF83959 Pharmacol. Biochem Behav. 80 2005 597 601 (Pubitemid 41583208)