MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial

American Journal of Clinical Nutrition

Volumn 100, Issue 2, 2014, Pages 719-731

  Corella, Dolores ^a,b   Sorlí, Jose V ^a,b   Estruch, Ramon ^b,c   Coltell, Oscar ^b,d   Ortega Azorín, Carolina ^a,b   Portolés, Olga ^a,b   Martínez González, Miguel Ángel ^b,e   Bulló, Mónica ^b,f   Fitó, Montserrat ^b,g   Arós, Fernando ^b,h   Lapetra, José ^b,i   Asensio, Eva M ^a,b   Sáez, Guillermo T ^a,b   Serra Majem, Lluís ^b,j   Muñoz Bravo, Carlos ^b,k   Ruiz Gutiérrez, Valentina ^b,l   Fiol, Miquel ^b,m   Vinyoles, Ernest ^b,n   Pintó, Xavier ^b,o   Richardson, Kris ^p   Ros, Emilio ^b,c   Ordovás, Jose M ^p,q,r   more..

^a UNIVERSITY OF VALENCIA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d UNIVERSITAT JAUME I   (Spain)

^e UNIVERSITY OF NAVARRA   (Spain)

^f UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^g INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^h HOSPITAL TXAGORRITXU   (Spain)

ⁱ Primary Care Center Sevilla Norte   (Spain)

^j UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^k UNIVERSITY OF MÁLAGA   (Spain)

^l INSTITUTO DE LA GRASA   (Spain)

^m HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

ⁿ INSTITUT CATALÀ DE LA SALUT   (Spain)

^o HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^p TUFTS UNIVERSITY   (United States)

^q IMDEA FOOD INSTITUTE   (Spain)

^r CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; LIPOPROTEIN LIPASE; LPL PROTEIN, HUMAN; MICRORNA; MIRN410 MICRORNA, HUMAN; OLIVE OIL; VEGETABLE OIL;

3' UNTRANSLATED REGION; AGED; CHEMISTRY; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DIET THERAPY; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETICS; HUMAN; HYPERTRIGLYCERIDEMIA; INCIDENCE; MALE; MEDITERRANEAN DIET; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; NUT; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; STROKE; SURVIVAL; VERY ELDERLY;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; COHORT STUDIES; DIET, MEDITERRANEAN; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERTRIGLYCERIDEMIA; INCIDENCE; LIPOPROTEIN LIPASE; MALE; MICRORNAS; MIDDLE AGED; NUTS; PLANT OILS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SPAIN; STROKE; SURVIVAL ANALYSIS;

EID: 84905372264     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.113.076992     Document Type: Article

References (44)

1. Siasos G, Tousoulis D, Tourikis P, Mazaris S, Zakynthinos G, Oikonomou E, Kokkou E, Kollia C, Stefanadis C. MicroRNAs in cardiovascular therapeutics. Curr Top Med Chem 2013;13:1605-18.
2. Hennessy EJ, Moore KJ. Using microRNA as an alternative treatment for hyperlipidemia and cardiovascular disease: cardio-miRs in the pipeline. J Cardiovasc Pharmacol 2013;62:247-54.
3. Yates LA, Norbury CJ, Gilbert RJ. The long and short of microRNA. Cell 2013;153:516-9.
4. Rayner KJ, Fernandez-Hernando C, Moore KJ. MicroRNAs regulating lipid metabolism in atherogenesis. Thromb Haemost 2012;107:642-7.
5. Fiedler J, Thum T. MicroRNAs in myocardial infarction. Arterioscler Thromb Vasc Biol 2013;33:201-5.
6. Hata A. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol 2013;75:69-93.
7. Sethupathy P, Collins FS. MicroRNA target site polymorphisms and human disease. Trends Genet 2008;24:489-97.
8. Salzman DW, Weidhaas JB. SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. Pharmacol Ther 2013;137:55-63.
9. Richardson K, Nettleton JA, Rotllan N, Tanaka T, Smith CE, Lai CQ, Parnell LD, Lee YC, Lahti J, Lemaitre RN, et al. Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Am J Hum Genet 2013;92:5-14.
10. Preiss-Landl K, Zimmermann R, Hämmerle G, Zechner R. Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol 2002;13:471-81.
11. Davies BS, Beigneux AP, Fong LG, Young SG. New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol 2012;23:35-42.
12. Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, et al. Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circ Res 2008;102:250-6.
13. Tang W, Apostol G, Schreiner PJ, Jacobs DR, Boerwinkle E, Fornage M. Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Circ Cardiovasc Genet 2010;3:179-86.
14. Smith AJ, Palmen J, Putt W, Talmud PJ, Humphries SE, Drenos F. Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar. Hum Mol Genet 2010;19:3936-47.
15. Sagoo GS, Tatt I, Salanti G, Butterworth AS, Sarwar N, van Maarle M, Jukema JW, Wiman B, Kastelein JJ, Bennet AM, et al. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol 2008;168:1233-46.
16. Johansen CT, Hegele RA. The complex genetic basis of plasma triglycerides. Curr Atheroscler Rep 2012;14:227-34.
17. Mo X, Liu X, Wang L, Li H, Lu X, Huang J, Chen J, Cao J, Li J, Chen S, et al. Lipoprotein lipase gene polymorphism rs1059611 functionally influences serum lipid concentrations. Atherosclerosis 2013;229:511-6.
18. Cho YS, Go MJ, Han HR, Cha SH, Kim HT, Min H, Shin HD, Park C, Han BG, Cho NH, et al. Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus. Exp Mol Med 2008;40:523-32.
19. Benlian P, De Gennes JL, Foubert L, Zhang H, Gagné SE, Hayden M. Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene. N Engl J Med 1996;335:848-54.
20. Wang C, Sun T, Li H, Bai J, Li Y. Lipoprotein lipase Ser447Ter polymorphism associated with the risk of ischemic stroke: a metaanalysis. Thromb Res 2011;128:e107-12.
21. Munshi A, Babu MS, Kaul S, Rajeshwar K, Balakrishna N, Jyothy A. Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes. J Neurol Sci 2012;318:51-4.
22. Luk AO, Wang Y, Ma RC, Tam CH, Ng MC, Lam V, Yang X, Baum L, Tong PC, Chan JC, et al. Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 diabetes-an 8-year prospective cohort analysis of 1327 Chinese patients. Atherosclerosis 2011;215:130-5.
23. Goodarzi MO, Wong H, Quiñones MJ, Taylor KD, Guo X, Castellani LW, Antoine HJ, Yang H, Hsueh WA, Rotter JI. The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity. J Clin Endocrinol Metab 2005;90:4816-23.
24. Deo RC, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA Jr, Wilson JG. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet 2009;5:e1000342.
25. Garcia-Rios A, Delgado-Lista J, Perez-Martinez P, Phillips CM, Ferguson JF, Gjelstad IM, Williams CM, Karlström B, Kieć-Wilk B, Blaak EE, et al. Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n26 polyunsaturated fatty acids to modulate lipid metabolism. Atherosclerosis 2011;218:416-22.
26. Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, et al. Interaction effects of lipoprotein lipase polymorphisms with lifestyle on lipid levels in a Korean population: a cross-sectional study. Genomics Inform 2012;10:88-98.
27. Baik I, Lee S, Kim SH, Shin C. Lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fat to modulate serum HDL-cholesterol concentrations. J Nutr 2013;143:1618-25.
28. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90.
29. Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 2006;145:1-11.
30. Fernández-Ballart JD, Piñol JL, Zazpe I, Corella D, Carrasco P, Toledo E, Perez-Bauer M, Martínez-González MA, Salas-Salvadó J, Martín-Moreno JM. Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br J Nutr 2010;103:1808-16.
31. Schröder H, Fitó M, Estruch R, Martínez- González MA, Corella D, Salas-Salvadó J, Lamuela-Raventós R, Ros E, Salaverría I, Fiol M, et al. A short screener is valid for assessingMediterranean diet adherence among older Spanish men and women. J Nutr 2011;141:1140-5.
32. Fandos M, Corella D, Guillén M, Portolés O, Carrasco P, Iradi A, Martínez-González MA, Estruch R, Covas MI, Lamuela-Raventós RM, et al. Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population. Free Radic Res 2009;43:1179-86.
33. Knol MJ, van der Tweel I, Grobbee DE, Numans ME, Geerlings MI. Estimating interaction on an additive scale between continuous determinants in a logistic regression model. Int J Epidemiol 2007;36:1111-8.
34. Sun X, Briel M, Walter SD, Guyatt GH. Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses. BMJ 2010;340:c117.
35. Zhao H, Wang J, Gao L, Wang R, Liu X, Gao Z, Tao Z, Xu C, Song J, Ji X, et al. MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke 2013;44:1706-13.
36. Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, et al. Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a largeanimal model. Circulation 2013;128:1066-75.
37. Chen J, Yang T, Yu H, Sun K, Shi Y, Song W, Bai Y, Wang X, Lou K, Song Y, et al. A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. Hum Mol Genet 2010;19:2524-33.
38. Yuan M, Zhan Q, Duan X, Song B, Zeng S, Chen X, Yang Q, Xia J. A functional polymorphism at microRNA-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population. Atherosclerosis 2013;226:447-52.
39. Liu ME, Liao YC, Lin RT, Wang YS, Hsi E, Lin HF, Chen KC, Juo SH. A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis. Atherosclerosis 2013;228:161-7.
40. Huggins GS, Papandonatos GD, Erar B, Belalcazar LM, Brautbar A, Ballantyne C, Kitabchi AE, Wagenknecht LE, Knowler WC, Pownall HJ, et al. Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus? The Action for Health in Diabetes (Look AHEAD) Study. Circ Cardiovasc Genet 2013;6:391-9.
41. Khan S, Minihane A-M, Talmud PJ, Wright JW, Murphy MC, Williams CM, Griffin BA. Dietary long-chain n23 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. J Lipid Res 2002;43:979-85.
42. Hennessy E, Clynes M, Jeppesen PB, O'Driscoll L. Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. Biochem Biophys Res Commun 2010;396:457-62.
43. Ramirez CM, Dávalos A, Goedeke L, Salerno AG, Warrier N, Cirera-Salinas D, Suárez Y, Fernández-Hernando C. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 2011;31:2707-14.
44. Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaillé J. A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res 2004;14:1741-8.