Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism

Atherosclerosis

Volumn 218, Issue 2, 2011, Pages 416-422

  Garcia Rios, Antonio ^a,b   Delgado Lista, Javier ^a,b   Perez Martinez, Pablo ^a,b   Phillips, Catherine M ^c   Ferguson, Jane F ^d   Gjelstad, Ingrid M F ^e   Williams, Christine M ^f   Karlström, Brita ^g   Kieć Wilk, Beata ^h   Blaak, Ellen E ⁱ   Lairon, Denis ^j   Planells, Richard ^j   Malczewska Malec, Małgorzata ^k   Defoort, Catherine ^j   Riserus, Ulf ^g   Saris, Wim H M ⁱ   Lovegrove, Julie A ^f   Drevon, Christian A ^k   Roche, Helen M ^d   Lopez Miranda, Jose ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF READING   (United Kingdom)

^g UPPSALA UNIVERSITY   (Sweden)

^h JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

ⁱ MAASTRICHT UNIVERSITY   (Netherlands)

^j INSERM   (France)

^k UNIVERSITY OF OSLO   (Norway)

more..

Author keywords

Gene nutrient interactions; LPL gene; Metabolic syndrome; N 6 PUFA; Nutrigenetics; Polymorphism

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 6 FATTY ACID; TRIACYLGLYCEROL;

ADULT; AGED; ALLELE; ARTICLE; FEMALE; GENE LOCUS; GENETIC VARIABILITY; HUMAN; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MOLECULAR INTERACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ALLELES; COHORT STUDIES; EUROPE; FATTY ACIDS, OMEGA-6; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VARIATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LIPID METABOLISM; LIPIDS; LIPOPROTEIN LIPASE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES;

EID: 81155161878     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.07.092     Document Type: Article

References (29)

1. Shaw D.I., Hall W.L., Williams C.M. Metabolic syndrome: what is it and what are the implications?. Proc Nutr Soc 2005, 64:349-357.
2. Henneman P., Aulchenko Y.S., Frants R.R., et al. The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits. Diabetes Care 2010, 33(4):908-913.
3. Phillips C.M., Goumidi L., Bertrais S., et al. Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults. J Nutr 2010, 140(2):238-244.
4. Warodomwichit D., Arnett D.K., Kabagambe E.K., et al. Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. J Nutr 2009, 139(3):439-446.
5. Goldberg I.J. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 1996, 37(4):693-707.
6. Wang H., Eckel R.H. Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab 2009, 297(2):E271-E288. 2009.
7. López-Miranda J., Cruz G., Gómez P., et al. The influence of lipoprotein lipase gene variation on postprandial lipoprotein metabolism. J Clin Endocrinol Metab 2004, 89(9):4721-4728.
8. Webster R.J., Warrington N.M., Weedon M.N., et al. The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia 2009, 52(1):106-114.
9. Sagoo G.S., Tatt I., Salanti G., et al. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol 2008, 168(11):1233-1246.
10. Warensjö E., Risérus U., Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 2005, 48(10):1999-2005.
11. Clarke S.D. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr 2001, 131(4):1129-1132.
12. Ferguson J.F., Phillips C.M., Tierney A.C., et al. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 2010, 91(3):794-801.
13. Perez-Martinez P., Moreno-Conde M., Cruz-Teno C., et al. Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study. Atherosclerosis 2010, 209(2):533-538.
14. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001, 285(19):2486-2497.
15. Tierney A.C., McMonagle J., Shaw D.I., et al. Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study. Int J Obes (Lond) 2010, (October). [Epub ahead of print].
16. Hercberg S., Galan P., Preziosi P., et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004, 164:2335-2342.
17. Rip J., Sierts J.A., Vaessen S.F., Kastelein J.J., Twisk J., Kuivenhoven J.A. Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice. Atherosclerosis 2007, 194(1):55-61.
18. Rip J., Nierman M.C., Ross C.J., et al. Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation. Arterioscler Thromb Vasc Biol 2006, 26(6):1236-1245.
19. Zilversmit D. Atherogenesis a postprandial phenomenon. Circulation 1979, 60:473-485.
20. Goldberg I. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 1996, 37:693-707.
21. Robinson D.S., Cryer A., Davies P. The role of clearing-factor lipase (lipoprotein lipase) in the transport of plasma triglycerides. Proc Nutr Soc 1975, 34(3):211-215.
22. Cryer A., Davies P., Williams E.R., Robinson D.S. The clearing-factor lipase activity of isolated fat-cells. Biochem J 1975, 146(2):481-488.
23. Lai C.Q., Corella D., Demissie S., et al. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study. Circulation 2006, 113(17):2062-2070.
24. Sampath H., Ntambi J.M. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 2005, 25:317-340.
25. Madsen L., Pedersen L.M., Liaset B., et al. cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. J Biol Chem 2008, 283(11):7196-7205.
26. Fontaine-Bisson B., El-Sohemy A. Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and plasma high-density lipoprotein-cholesterol concentrations in a population of young adults. J Nutrigenet Nutrigenomics 2008, 1(5):215-223.
27. Junyent M., Parnell L.D., Lai C.Q., et al. ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study. Nutr Metab Cardiovasc Dis 2009, (October). [Epub ahead of print].
28. Nierman M.C., Rip J., Kuivenhoven J.A., et al. Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes. Atherosclerosis 2007, 194(2):446-451.
29. Nierman M.C., Prinsen B.H., Rip J., et al. Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers. Arterioscler Thromb Vasc Biol 2005, 25(11):2410-2415.