MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation

Stroke

Volumn 44, Issue 6, 2013, Pages 1706-1713

  Zhao, Haiping ^a   Wang, Jun ^b   Gao, Li ^a   Wang, Rongliang ^a   Liu, Xiangrong ^a   Gao, Zhi ^a   Tao, Zhen ^a   Xu, Changmin ^a   Song, Juexian ^a   Ji, Xunming ^a   Luo, Yumin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Brain ischemia; Cell cycle; Microglia; miR 424

Indexed keywords

ADAPTOR PROTEIN; CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; LENTIVIRUS VECTOR; MESSENGER RNA; MICRORNA; MICRORNA 424; PROTEIN CDC25A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL ACTIVITY; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BRAIN ISCHEMIA; CELL CYCLE; MICROGLIA; MIR-424;

AGED; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CELL CYCLE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRAVENTRICULAR; LENTIVIRUS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; MICRORNAS; MIDDLE AGED;

EID: 84880169915     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000504     Document Type: Article

References (25)

1. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, et al. miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res. 2008;36:5391-5404.
2. Rissland OS, Hong SJ, Bartel DP. MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes. Mol Cell. 2011;43:993-1004.
3. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M, et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation. Proc Natl Acad Sci USA. 2007;104:19849-19854.
4. Rahimian A, Soleimani M, Kaviani S, Aghaee-Bakhtiari SH, Atashi A, Arefan E, et al. Bypassing the maturation arrest in myeloid cell line U937 by over-expression of microRNA-424. Hematology. 2011;16:298-302.
5. Marinescu VD, Kohane IS, Riva A. MAPPER: a search engine for the computational identifcation of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics. 2005;6:79.
6. Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H, et al. Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol. 2005;25:2832-2845.
7. Sarkar S, Dey BK, Dutta A. MiR-322/424 and-503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol Biol Cell. 2010;21:2138-2149.
8. Gao J, Han J, Zhu HF, Yang TT, Fan QY, Ma BA. Expressions of miR-424 during differentiation of human bone marrow-derived mesenchymal stem cells. Chinese J Trauma. 2010; 26: 752-756.
9. Huang S, Wang SH, Han Q, Zhao CH. MiR-424 negatively regulates adipogenic differentiation of human adipose tissue-derived mesenchy-mal stem cells. Basic & Clinical Medicine. 2012; 32: 114-118.
10. Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW, et al. Expression profle of MicroRNAs in young stroke patients. PLoS One. 2009;4:e7689.
11. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, et al. Brain and blood microRNA expression profling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30:92-101.
12. Hutchison ER, Okun E, Mattson MP. The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair. Neuromolecular Med. 2009;11:153-161.
13. Burton MD, Sparkman NL, Johnson RW. Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide- induced sickness behavior. J Neuroinfammation. 2011;8:54.
14. Hata R, Mies G, Wiessner C, Fritze K, Hesselbarth D, Brinker G, et al. A reproducible model of middle cerebral artery occlusion in mice: hemo-dynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab. 1998;18:367-375.
15. Yin XM, Luo Y, Cao G, Bai L, Pei W, Kuharsky DK, et al. Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. J Biol Chem. 2002;277:42074-42081.
16. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318.
17. Smadja D. Pharmacological revascularization of acute ischaemic stroke: focus on challenges and novel strategies. CNS Drugs. 2012;26:309-318.
18. Tanahashi N. [Thrombolysis by intravenous tissue plasminogen activator (t-PA)-current status and future direction]. Brain Nerve. 2009;61:41-52.
19. Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008;39:959-966.
20. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318.
21. Minghetti L, Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol. 1998;54:99-125.
22. Hanisch UK. Microglia as a source and target of cytokines. Glia. 2002;40:140-155.
23. Zhang Q, Chen C, Lü J, Xie M, Pan D, Luo X, et al. Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat. Glia. 2009;57:908-920.
24. Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, et al. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Mol Med. 2010;16:278-286.
25. Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, et al. The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. J Neurosci. 2006;26:8819-8828.