Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts

Age

Volumn 36, Issue 3, 2014, Pages 1079-1094

  He, Tianyuan ^a   Quan, Taihao ^a   Shao, Yuan ^a   Voorhees, John J ^a   Fisher, Gary J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Connective tissue; Extracellular matrix; Oxidative stress; Signal transduction; Skin

Indexed keywords

ACETYLCYSTEINE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; PROTEIN SERINE THREONINE KINASE; SCAVENGER; SMAD3 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; EXPOSURE; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN;

ACETYLCYSTEINE; COLLAGEN TYPE I; FIBROBLASTS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN; SKIN AGING; SMAD3 PROTEIN;

EID: 84905369458     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-014-9623-6     Document Type: Article

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