Social isolation stress-induced fear memory deficit is mediated by down-regulated neuro-signaling system and Egr-1 expression in the brain

Neurochemical Research

Volumn 39, Issue 5, 2014, Pages 875-882

  Okada, Ryo ^a   Matsumoto, Kinzo ^a   Tsushima, Ryohei ^a   Fujiwara, Hironori ^a   Tsuneyama, Koichi ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

ADHD model; Egr 1; Long term fear memory; Neuro signaling system; Social isolation stress

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; GLUTAMATE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANSCRIPTION FACTOR EGR 1; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; EGR1 PROTEIN, MOUSE; EGR2 PROTEIN, MOUSE;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; ATTENTION DEFICIT DISORDER; AUDITORY MEMORY; CONTROLLED STUDY; CYTOSOLIC FRACTION; DOWN REGULATION; FEAR; HIPPOCAMPUS; MALE; MEMORY CONSOLIDATION; MOTOR PERFORMANCE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOCIAL ISOLATION; SOCIAL STRESS; TRAINING; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; BRAIN CORTEX; CONDITIONED REFLEX; INSTITUTE FOR CANCER RESEARCH MOUSE; MEMORY; MEMORY DISORDER; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA; MUS; RODENTIA;

ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CONDITIONING, CLASSICAL; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; EARLY GROWTH RESPONSE PROTEIN 2; FEAR; HIPPOCAMPUS; MALE; MEMORY; MEMORY DISORDERS; MICE, INBRED ICR; NEURONAL PLASTICITY; SIGNAL TRANSDUCTION; SOCIAL ISOLATION; STRESS, PSYCHOLOGICAL;

EID: 84905366761     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-014-1283-5     Document Type: Article

References (36)

1. Matsumoto K, Cai B, Satoh T, Ohta H, Watanabe H (1991) Desipramine enhances isolation-induced aggressive behavior in mice. Pharmacol Biochem Behav 39:167-170
2. Ojima K, Matsumoto K, Tohda M, Watanabe H (1995) Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in pentobarbital sleep. Brain Res 684:87-94
3. Matsumoto K, Uzunova V, Pinna G, Taki K, Uzunov DP, Watanabe H, Mienville JM, Guidotti A, Costa E (1999) Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology 38:955-963 (Pubitemid 29240612)
4. Matsumoto K, Pinna G, Puia G, Guidotti A, Costa E (2005) Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress 8:85-93 (Pubitemid 40979003)
5. A receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders. Stress 10:3-12
6. Powell SB, Geyer MA, Preece MA, Pitcher LK, Reynolds GP, Swerdlow NR (2003) Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats. Neuroscience 119:233-240 (Pubitemid 36577426)
7. Fone KC, Porkess MV (2008) Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 32:1087-1102
8. Matsumoto K, Ono K, Ouchi H, Tsusima R-H, Murakami Y (2012) Social isolation stress down-regulates cortical early growth response 1 (Egr-1) in mice. Neurosci Res 73:257-262
9. Li L, Carter J, Gao X, Whitehead J, Tourtellotte WG (2005) The neuroplasticity-associated Arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol Cell Biol 25:10286-10300 (Pubitemid 41681955)
10. Yamada K, Gerber DJ, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Aruga J, Minabe Y, Tonegawa S, Yoshikawa T (2007) Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc Natl Acad Sci USA 104:2815-2820 (Pubitemid 46327962)
11. Ouchi H, Ono K, Murakami Y, Matsumoto K (2013) Social isolation induces deficit of latent learning performance in mice: a putative animal model of attention deficit/hyperactivity disorder. Behav Brain Res 238:146-153
12. Mokin M, Keifer J (2005) Expression of the immediate-early gene-encoded protein Egr-1 (zif268) during in vitro classical conditioning. Learn Mem 12:144-149 (Pubitemid 40517081)
13. Malkani S, Wallace KJ, Donley MP, Rosen JB (2004) An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning. Learn Mem 11:617-624 (Pubitemid 39299713)
14. Rosen JB, Adamec RE, Thompson BL (2005) Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predator. Behav Brain Res 162:279-288 (Pubitemid 40828541)
15. Knapska E, Kaczmarek L (2004) A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK? Prog Neurobiol 74:183-211 (Pubitemid 39535508)
16. Yamada M, Hayashida M, Zhao Q, Shibahara N, Tanaka K, Miyata T, Matsumoto K (2011) Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice. J Ethnopharmacol 135:737-746
17. Le XT, Pham HT, Do PT, Fujiwara H, Tanaka K, Li F, Van Nguyen T, Nguyen KM, Matsumoto K (2013) Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems. Neurochem Res 38:2201-2215
18. Casu MA, Sanna A, Spada GP, Falzoi M, Mongeau R, Pani L (2007) Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens. Brain Res 1141:15-24 (Pubitemid 46394502)
19. Zhao Q, Matsumoto K, Tsuneyama K, Tanaka K, Li F, Shibahara N, Miyata T, Yokozawa T (2011) Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J Pharmacol Sci 117:230-242
20. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci 20:3993-4001 (Pubitemid 30365669)
21. Pape HC, Pare D (2010) Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Physiol Rev 90:419-463
22. Cowan N (2008) What are the differences between long-term, short-term, and working memory? Prog Brain Res 169:323-338
23. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39 (Pubitemid 23020772)
24. Neves G, Cooke SF, Bliss TV (2008) Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci 9:65-75 (Pubitemid 350295694)
25. Maddox SA, Monsey MS, Schafe GE (2011) Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala. Learn Mem 18:24-38
26. Cooke SF, Bliss TV (2006) Plasticity in the human central nervous system. Brain 129:1659-1673 (Pubitemid 43999401)
27. Lau GC, Saha S, Faris R, Russek SJ (2004) Up-regulation of NMDAR1 subunit gene expression in cortical neurons via a PKA-dependent pathway. J Neurochem 88:564-575 (Pubitemid 38140201)
28. Zhao H, Li Q, Pei X, Zhang Z, Yang R, Wang J, Li Y (2009) Long-term ginsenoside administration prevents memory impairment in aged C57BL/6 J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behav Brain Res 201:311-317
29. Chen BS, Roche KW (2007) Regulation of NMDA receptors by phosphorylation. Neuropharmacology 53:362-368
30. Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996) Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16:1179-1188 (Pubitemid 26227239)
31. Shaywitz AJ, Greenberg ME (1999) CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861 (Pubitemid 29449210)
32. Lamprecht R (1999) CREB: a message to remember. Cell Mol Life Sci 55:554-563
33. Vaynman S, Ying Z, Gomez-Pinilla F (2007) The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience 144:825-833 (Pubitemid 46013982)
34. Gomez-Pinilla F, Vaynman S, Ying Z (2008) Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 28:2278-2287
35. Moriguchi S, Han F, Nakagawasai O, Tadano T, Fukunaga K (2006) Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice. J Neurochem 97:22-29
36. Hozumi S, Nakagawasai O, Tan-No K, Niijima F, Yamadera F, Murata A, Arai Y, Yasuhara H, Tadano T (2003) Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy. Behav Brain Res 138:9-15 (Pubitemid 35463233) Technology