DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer

Journal of the National Cancer Institute

Volumn 106, Issue 7, 2014, Pages

  Woditschka, Stephan ^a   Evans, Lynda ^a,m   Duchnowska, Renata ^c   Reed, L Tiffany ^a   Palmieri, Diane ^a,n   Qian, Yongzhen ^d   Badve, Sunil ^e   Sledge, George ^f,o   Gril, Brunilde ^a   Aladjem, Mirit I ^b   Fu, Haiqing ^b   Flores, Natasha M ^a,o   Gökmen Polar, Yesim ^f   Biernat, Wojciech ^g   Szutowicz Zielińska, Ewa ^h   Mandat, Tomasz ⁱ   Trojanowski, Tomasz ^j   Och, Waldemar ^k   Czartoryska Arlukowicz, Bogumiła ^l   Jassem, Jacek ^h   Mitchell, James B ^a   Steeg, Patricia S ^a   more..

^a NATIONAL CANCER INSTITUTE   (United States)

^b Women's Cancers Section   (United States)

^c MILITARY INSTITUTE OF MEDICINE   (Poland)

^d Laboratory of Cancer Prevention   (United States)

^e Departments of Pathology and Laboratory Medicine   (United States)

^f INDIANA UNIVERSITY   (United States)

^g Departments of Medicine Indiana University School of Medicine ^*  (United States)

^h MEDICAL UNIVERSITY OF GDANSK   (Poland)

ⁱ INSTITUTE OF ONCOLOGY   (Poland)

^j MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^k Ministry of Interior Affairs Hospital   (Poland)

^l Department of Radiotherapy II   (Poland)

^m Teach for America   (United States)

ⁿ NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^o STANFORD UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TEMPOL;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARD1 GENE; BRAIN METASTASIS; BRAIN TUMOR CELL LINE; BREAST CANCER; BREAST CANCER CELL LINE; CARCINOGENESIS; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; GENE; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LENTIVIRINAE; LUNG METASTASIS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RAD51 GENE; STUDENT T TEST; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

ANIMALS; ANTIOXIDANTS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLIC N-OXIDES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RAD51 RECOMBINASE; REACTIVE OXYGEN SPECIES; SPIN LABELS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84905274897     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dju145     Document Type: Article

References (56)

1. Steeg P, Camphausen K, Smith Q. Brain metastases as preventive and therapeutic targets. Nature Rev Cancer. 2011;11(5):352-363.
2. Lin N, Bellon J, Winer E. CNS metastases in breast cancer. J Clin Oncol. 2004;22:3608-3617.
3. Brufsky A, Mayer M, Rugo H, et al. Central nervous system metastases in patients with Her2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registHER. Clin Cancer Res 2011;17(14):4834-4843.
4. Lin N, Claus E, Sohl J, et al. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer. High incidence of central nervous system metastases. Cancer. 2008;113(10):2638-2645.
5. Bendell J, Domchek S, Burstein H, et al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003;97(12):2972-2977.
6. Lockman PR, Mittapalli RK, Taskar KS, et al. Heterogeneous bloodtumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clin Cancer Res. 2010;16(23):5664-5678.
7. Carbonell W, Ansorge O, Sibson N, et al. The vascular basement membrane as "soil" in brain metastasis. PloS One. 2009;4(6):e5857.
8. Fitzgerald DP, Palmieri D, Hua E, et al. Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization. Clin Exp Metastasis. 2008;25(7):799-810.
9. Sierra A, Price J, Garcia-Ramirez M, et al. Astrocyte derived cytokines contribute to the metastatic brain specificity of breast cancer cells. Lab Invest. 1997;77(4):357-368.
10. Heyn C, Ronald JA, Ramadan SS, et al. In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain. Magn Reson Med. 2006;56(5):1001-1010.
11. Kienast Y, al. E. Real-time imaging reveals the single steps in brain metastasis formation. Nature Med. 2010;16(1):116-122.
12. Bos P, Zhang X, Nadal C, et al. Genes that mediate breast cancer metastasis to the brain. Nature. 2009;459(7249):1005-1010.
13. San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Annu Rev Biochem. 2008;77:229-257.
14. Hashimoto Y, Puddu F, Costanzo V. RAD51-and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol. 2012;19(1):17-24.
15. Long DT, Räschle M, Joukov V, et al. Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science. 2011;333(6038):84-87.
16. Feng Z, Zhang J. A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest. Nucleic Acids Res. 2012;40(2):726-738.
17. Badie S, Escandell JM, Bouwman P, et al. BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol. 2010;17(12):1461-1469.
18. Sung P, Klein H. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat Rev Mol Cell Biol. 2006;7(10):739-750.
19. Sage JM, Gildemeister OS, Knight KL. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem. 2010;285(25):18984-18990.
20. Schlacher K, Christ N, Siaud N, et al. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 2011;145(4):529-542.
21. Petermann E, Orta ML, Issaeva N, et al. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell. 2010;37(4):492-502.
22. Hashimoto Y, Chaudhuri A, Lopes M, et al. Rad51 protects nascent DNA from MRE11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol. 2010;17(11):1305-1311.
23. Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 2012;22(1):106-116.
24. Kiyohara E, Tamai K, Katayama I, et al. The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma. Gene Ther. 2012;19(7):734-741.
25. Ito M, Yamamoto S, Nimura K, et al. Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin. J Gene Med. 2005;7(8):1044-1052.
26. Pal J, Fulciniti M, Nanjappa P, et al. Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth. Cancer Genom Proteom. 2012;9(2):55-66.
27. Ohnishi T, Taki T, Hiraga S, et al. In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene. Biochem Biophys Res Commun. 1998;245(2):319-324.
28. Saydam O, Saydam N, Glauser DL, et al. HSV-1 amplicon-mediated posttranscriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation. Gene Ther. 2007;14(15):1143-1151.
29. Bertrand P, Lambert S, Joubert C, et al. Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells. Oncogene. 2003;22(48):7587-7592.
30. Brzovic PS, Rajagopal P, Hoyt DW, et al. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001;8(10):833-837.
31. Wu LC, Wang ZW, Tsan JT, et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet. 1996;14(4):430-440.
32. Mallery DL, Vandenberg CJ, Hiom K. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. EMBO J. 2002;21(24):6755-6762.
33. Xia Y, Pao GM, Chen HW, et al. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003;278(7):5255-5263.
34. Drost R, Bouwman P, Rottenberg S, et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell. 2011;20(6):797-809.
35. Fabbro M, Rodriguez JA, Baer R, et al. BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. J Biol Chem. 2002;277(24):21315-21324.
36. Simons AM, Horwitz AA, Starita LM, et al. BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Res. 2006;66(4):2012-2018.
37. Westermark UK, Reyngold M, Olshen AB, et al. BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol. 2003;23(21):7926-7936.
38. Scully R, Chen J, Ochs RL, et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 1997;90(3):425-435.
39. Chen J, Silver DP, Walpita D, et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998;2(3):317-328.
40. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009;106(17):7155-7160.
41. Livingston DM. Cancer. Complicated supercomplexes. Science. 2009;324(5927):602-603.
42. Zhang F, Ma J, Wu J, et al. PALB2 links BRCA1 and BRCA2 in the DNAdamage response. Curr Biol. 2009;19(6):524-529.
43. Irminger-Finger I, Leung WC, Li J, et al. Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis. Mol Cell. 2001;8(6):1255-1266.
44. Irminger-Finger I, Jefford CE. Is there more to BARD1 than BRCA1? Nat Rev Cancer. 2006;6(5):382-391.
45. Palmieri D, Bronder JL, Herring JM, et al. Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res. 2007;67(9):4190-4198.
46. Palmieri D, Lockman PR, Thomas FC, et al. Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. Clin Cancer Res. 2009;15(19):6148-6157.
47. Wu W, Koike A, Takeshita T, et al. The ubiquitin E3 ligase activity of BRCA1 and its biological functions. Cell Div. 2008;3:1.
48. Dong Y, Hakimi MA, Chen X, et al. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003;12(5):1087-99.
49. Duchnowska R, Jassem J, Thorat M, et al. Gene expression analysis for prediction of early brain metastasis (BM) in HER-2-positive (HER2+) breast cancer patients (pts). J Clin Oncol. 2008;26(Suppl.):abstract 1019.
50. Zhang XH, Wang Q, Gerald W, et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009;16(1):67-78.
51. Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. J Clin Oncol. 2004;22(17):3608-17.
52. Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:428010.
53. Karanjawala ZE, Murphy N, Hinton DR, et al. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002;12(5):397-402.
54. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993;362(6422):709-715.
55. Soule BP, Hyodo F, Matsumoto K, et al. The chemistry and biology of nitroxide compounds. Free Radic Biol Med. 2007;42(11):1632-1650.
56. Dizdaroglu M, Jaruga P. Mechanisms of free radical-induced damage to DNA. Free Radic Res. 2012;46(4):382-419