EpCAM induction functionally links to the Wnt-enhanced cell proliferation in human keratinocytes

Cell Transplantation

Volumn 23, Issue 8, 2014, Pages 1031-1044

  Shen, Ching I ^a   Lee, Hsiu Chin ^a   Kao, Ying Hsien ^b   Wu, Chieh Shan ^c   Chen, Po Hung ^d   Lin, Shinn Zong ^e,f   Lai, Ping Shan ^a   Su, Hong Lin ^a,e  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d Chen Po Hung Dermatologic Clinic   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

Author keywords

Epidermal progenitor cells; Epithelial cell adhesion molecule (EpCAM); Keratinocyte; Proliferation; Wnt

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; RECOMBINANT PROTEIN; SHORT HAIRPIN RNA; WNT3A PROTEIN;

ARTICLE; CELL CYCLE PROGRESSION; CELL DENSITY; CELL GROWTH; CELL PROLIFERATION; CELL RENEWAL; COLONY FORMATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION; WNT SIGNALING PATHWAY;

EID: 84905235289     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368913X666403     Document Type: Article

References (45)

1. Alonso, L.; Fuchs, E. Stem cells in the skin: Waste not, Wnt not. Genes Dev. 17(10): 1189-1200; 2003.
2. Baeuerle, P. A.; Gires, O. EpCAM (CD326) finding its role in cancer. Br. J. Cancer 96(3): 417-423; 2007.
3. Baker, C. M.; Verstuyf, A.; Jensen, K. B.; Watt, F. M. Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev. Biol. 343(1-2): 40-50; 2010.
4. Barrandon, Y.; Green, H. Three clonal types of keratinocyte with different capacities for multiplication. Proc. Natl. Acad. Sci. USA 84(8): 2302-2306; 1987.
5. Behrens, J.; Lustig, B. The Wnt connection to tumorigenesis. Int. J. Dev. Biol. 48(5-6): 477-487; 2004.
6. Ghali, L.; Wong, S. T.; Tidman, N.; Quinn, A.; Philpott, M. P.; Leigh, I. M. Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein. J. Invest. Dermatol. 122(2): 433-442; 2004.
7. Gudjonsson, J. E.; Johnston, A.; Stoll, S. W.; Riblett, M. B.; Xing, X.; Kochkodan, J. J.; Ding, J.; Nair, R. P.; Aphale, A.; Voorhees, J. J.; Elder, J. T. Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol. 130(7): 1849-1859; 2010.
8. Hampton, P. J.; Ross, O. K.; Reynolds, N. J. Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis. Br. J. Dermatol. 157(6): 1168-1177; 2007.
9. Imrich, S.; Hachmeister, M.; Gires, O. EpCAM and its potential role in tumor-initiating cells. Cell Adh. Migr. 6(1): 30-38; 2012.
10. Jensen, K. B.; Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc. Natl. Acad. Sci. USA 103(32): 11958-11963; 2006.
11. Jones, P. H.; Harper, S.; Watt, F. M. Stem cell patterning and fate in human epidermis. Cell 80(1): 83-93; 1995.
12. Jones, P. H.; Watt, F. M. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73(4): 713-724; 1993.
13. Klein, C. E.; Cordon-Cardo, C.; Soehnchen, R.; Cote, R. J.; Oettgen, H. F.; Eisinger, M.; Old, L. J. Changes in cell surface glycoprotein expression during differentiation of human keratinocytes. J. Invest. Dermatol. 89(5): 500-506; 1987.
14. Kocer, S. S.; Djuric, P. M.; Bugallo, M. F.; Simon, S. R.; Matic, M. Transcriptional profiling of putative human epithelial stem cells. BMC Genomics 9: 359; 2008.
15. Legg, J.; Jensen, U. B.; Broad, S.; Leigh, I.; Watt, F. M. Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Development 130(24): 6049-6063; 2003.
16. Lin, X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development 131(24): 6009-6021; 2004.
17. Lo Muzio, L.; Pannone, G.; Staibano, S.; Mignogna, M. D.; Grieco, M.; Ramires, P.; Romito, A. M.; De Rosa, G.; Piattelli, A. WNT-1 expression in basal cell carcinoma of head and neck. An immunohistochemical and confocal study with regard to the intracellular distribution of beta-catenin. Anticancer Res. 22(2A): 565-576; 2002.
18. Lorenz, K.; Rupf, T.; Salvetter, J.; Bader, A. Enrichment of human beta 1 bri/alpha 6 bri/CD71 dim keratinocytes after culture in defined media. Cells Tissues Organs 189 (6): 382-390; 2009.
19. Lu, T. Y.; Lu, R. M.; Liao, M. Y.; Yu, J.; Chung, C. H.; Kao, C. F.; Wu, H. C. Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J. Biol. Chem. 285(12): 8719-8732; 2010.
20. Maetzel, D.; Denzel, S.; Mack, B.; Canis, M.; Went, P.; Benk, M.; Kieu, C.; Papior, P.; Baeuerle, P. A.; Munz, M.; Gires, O. Nuclear signalling by tumour-associated antigen EpCAM. Nat. Cell. Biol. 11(2): 162-171; 2009.
21. Malanchi, I.; Peinado, H.; Kassen, D.; Hussenet, T.; Metzger, D.; Chambon, P.; Huber, M.; Hohl, D.; Cano, A.; Birchmeier, W.; Huelsken, J. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452(7187): 650-653; 2008.
22. Mathor, M. B.; Ferrari, G.; Dellambra, E.; Cilli, M.; Mavilio, F.; Cancedda, R.; De Luca, M. Clonal analysis of stably transduced human epidermal stem cells in culture. Proc. Natl. Acad. Sci. USA 93(19): 10371-10376; 1996.
23. Meijer, L.; Skaltsounis, A. L.; Magiatis, P.; Polychronopoulos, P.; Knockaert, M.; Leost, M.; Ryan, X. P.; Vonica, C. A.; Brivanlou, A.; Dajani, R.; Crovace, C.; Tarricone, C.; Musacchio, A.; Roe, S. M.; Pearl, L.; Greengard, P. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem. Biol. 10(12): 1255-1266; 2003.
24. Munz, M.; Baeuerle, P. A.; Gires, O. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-5629; 2009.
25. O'Driscoll, L.; McMorrow, J.; Doolan, P.; McKiernan, E.; Mehta, J. P.; Ryan, E.; Gammell, P.; Joyce, H.; O'Donovan, N.; Walsh, N.; Clynes, M. Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays. Mol. Cancer 5: 74; 2006.
26. Pellegrini, G.; Dellambra, E.; Golisano, O.; Martinelli, E.; Fantozzi, I.; Bondanza, S.; Ponzin, D.; McKeon, F.; De Luca, M. p63 identifies keratinocyte stem cells. Proc. Natl. Acad. Sci. USA 98(6): 3156-3161; 2001.
27. Piepkorn, M.; Fleckman, P.; Carney, H.; Linker, A. Glycosaminoglycan synthesis by human keratinocytes: Cell growth and medium calcium effects. J. Invest. Dermatol. 91(5): 492-498; 1988.
28. Poumay, Y.; Herphelin, F.; Smits, P.; De Potter, I. Y.; Pittelkow, M. R. High-cell-density phorbol ester and retinoic acid upregulate involucrin and downregulate suprabasal keratin 10 in autocrine cultures of human epidermal keratinocytes. Mol. Cell Biol. Res. Commun. 2(2): 138-144; 1999.
29. Poumay, Y.; Pittelkow, M. R. Cell density and culture factors regulate keratinocyte commitment to differentiation and expression of suprabasal K1/K10 keratins. J. Invest. Dermatol. 104(2): 271-276; 1995.
30. Reischl, J.; Schwenke, S.; Beekman, J. M.; Mrowietz, U.; Sturzebecher, S.; Heubach, J. F. Increased expression of Wnt5a in psoriatic plaques. J. Invest. Dermatol. 127(1): 163-169; 2007.
31. Rochat, A.; Kobayashi, K.; Barrandon, Y. Location of stem cells of human hair follicles by clonal analysis. Cell 76(6): 1063-1073; 1994.
32. Romanowska, M.; Evans, A.; Kellock, D.; Bray, S. E.; McLean, K.; Donandt, S.; Foerster, J. Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS One 4(4): e5354; 2009.
33. Ryle, C. M.; Breitkreutz, D.; Stark, H. J.; Leigh, I. M.; Steinert, P. M.; Roop, D.; Fusenig, N. E. Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones. Differentiation 40(1): 42-54; 1989.
34. Schmelzer, E.; Reid, L. M. EpCAM expression in normal, non-pathological tissues. Front. Biosci. 13: 3096-3100; 2008.
35. Song, J.; Chang, I.; Chen, Z.; Kang, M.; Wang, C. Y. Characterization of side populations in HNSCC: Highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One 5(7): e11456; 2010.
36. Stockinger, A.; Eger, A.; Wolf, J.; Beug, H.; Foisner, R. E-cadherin regulates cell growth by modulating proliferationdependent beta-catenin transcriptional activity. J. Cell Biol. 154(6): 1185-1196; 2001.
37. Tani, H.; Morris, R. J.; Kaur, P. Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. USA 97(20): 10960-10965; 2000.
38. Teh, M. T.; Blaydon, D.; Ghali, L. R.; Briggs, V.; Edmunds, S.; Pantazi, E.; Barnes, M. R.; Leigh, I. M.; Kelsell, D. P.; Philpott, M. P. Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J. Cell Sci. 120(Pt 2): 330-339; 2007.
39. Watt, F. M.; Collins, C. A. Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer. Cold Spring Harb. Symp. Quant. Biol. 73: 503-512; 2008.
40. Widelitz, R. B. Wnt signaling in skin organogenesis. Organogenesis 4(2): 123-133; 2008.
41. Williams, M. L.; Rutherford, S. L.; Ponec, M.; Hincenbergs, M.; Placzek, D. R.; Elias, P. M. Density-dependent variations in the lipid content and metabolism of cultured human keratinocytes. J. Invest. Dermatol. 91(1): 86-91; 1988.
42. Yamashita, T.; Budhu, A.; Forgues, M.; Wang, X. W. Activation of hepatic stem cell marker EpCAM by Wntbeta-catenin signaling in hepatocellular carcinoma. Cancer Res. 67(22): 10831-10839; 2007.
43. Yan, X.; Owens, D. M. The skin: A home to multiple classes of epithelial progenitor cells. Stem Cell Rev. 4(2): 113-118; 2008.
44. Yang, L.; Peng, R. Unveiling hair follicle stem cells. Stem Cell Rev. 6(4): 658-664; 2010.
45. Zhu, A. J.; Watt, F. M. beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126 (10): 2285-2298; 1999.