메뉴 건너뛰기




Volumn 392, Issue 1-2, 2014, Pages 249-257

Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling

Author keywords

Akt; Apoptosis; Chondrocytes; Ginsenoside Rg1; Osteoarthritis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; COLLAGENASE 3; CYTOCHROME C; DNA NUCLEOTIDYLEXOTRANSFERASE; GINSENOSIDE RG 1; INTERLEUKIN 1BETA; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; GINSENOSIDE;

EID: 84905194694     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2035-1     Document Type: Article
Times cited : (62)

References (34)
  • 1
    • 26444615136 scopus 로고    scopus 로고
    • The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes
    • DOI 10.1016/j.lfs.2005.05.052, PII S0024320505005813
    • Aida Y, Maeno M, Suzuki N, Shiratsuchi H, Motohashi M, Matsumura H (2005) The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes. Life Sci 77:3210-3221. doi:10.1016/j.lfs.2005.05.052 (Pubitemid 41433321)
    • (2005) Life Sciences , vol.77 , Issue.25 , pp. 3210-3221
    • Aida, Y.1    Maeno, M.2    Suzuki, N.3    Shiratsuchi, H.4    Motohashi, M.5    Matsumura, H.6
  • 2
    • 52949117087 scopus 로고    scopus 로고
    • The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis
    • doi:10.1002/jor.20683
    • Zhou PH, Liu SQ, Peng H (2008) The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. J Orthop Res 26:1643-1648. doi:10.1002/jor.20683
    • (2008) J Orthop Res , vol.26 , pp. 1643-1648
    • Zhou, P.H.1    Liu, S.Q.2    Peng, H.3
  • 3
    • 33847194975 scopus 로고    scopus 로고
    • Cell death and apoptosis in osteoarthritic cartilage
    • Kim HA, Blanco FJ (2007) Cell death and apoptosis in osteoarthritic cartilage. Curr Drug Targets 8:333-345
    • (2007) Curr Drug Targets , vol.8 , pp. 333-345
    • Kim, H.A.1    Blanco, F.J.2
  • 4
    • 54249096028 scopus 로고    scopus 로고
    • Caspases in apoptosis and beyond
    • doi:10.1038/onc.2008.297
    • Li J, Yuan J (2008) Caspases in apoptosis and beyond. Oncogene 27:6194-6206. doi:10.1038/onc.2008.297
    • (2008) Oncogene , vol.27 , pp. 6194-6206
    • Li, J.1    Yuan, J.2
  • 5
    • 78049390935 scopus 로고    scopus 로고
    • The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes
    • doi:10.1016/j.jep.2010.08.020
    • Ju XD, Deng M, Ao YF, Yu CL, Wang JQ, Yu JK, Cui GQ, Hu YL (2010) The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes. J Ethnopharmacol 132:414-420. doi:10.1016/j.jep.2010.08.020
    • (2010) J Ethnopharmacol , vol.132 , pp. 414-420
    • Ju, X.D.1    Deng, M.2    Ao, Y.F.3    Yu, C.L.4    Wang, J.Q.5    Yu, J.K.6    Cui, G.Q.7    Hu, Y.L.8
  • 6
    • 0035213530 scopus 로고    scopus 로고
    • Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion
    • doi:10.1007/s00441-001-0472-0
    • Antonsson B (2001) Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion. Cell Tissue Res 306:347-361. doi:10.1007/s00441-001-0472-0
    • (2001) Cell Tissue Res , vol.306 , pp. 347-361
    • Antonsson, B.1
  • 8
    • 45349094984 scopus 로고    scopus 로고
    • Mitochondrial dynamics and apoptosis
    • DOI 10.1101/gad.1658508
    • Suen DF, Norris KL, Youle RJ (2008) Mitochondrial dynamics and apoptosis. Genes Dev 22:1577-1590. doi:10.1101/gad.1658508 (Pubitemid 351846838)
    • (2008) Genes and Development , vol.22 , Issue.12 , pp. 1577-1590
    • Suen, D.-F.1    Norris, K.L.2    Youle, R.J.3
  • 9
    • 83355173227 scopus 로고    scopus 로고
    • IGF-1 and PDGF-bb suppress IL-1beta-induced cartilage degradation through down-regulation of NF-kappaB signaling: Involvement of Src/PI-3 K/AKT pathway
    • doi:10.1371/journal.pone.0028663
    • Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, Shakibaei M (2011) IGF-1 and PDGF-bb suppress IL-1beta-induced cartilage degradation through down-regulation of NF-kappaB signaling: involvement of Src/PI-3 K/AKT pathway. PLoS One 6:e28663. doi:10.1371/journal.pone.0028663
    • (2011) PLoS One , vol.6
    • Montaseri, A.1    Busch, F.2    Mobasheri, A.3    Buhrmann, C.4    Aldinger, C.5    Rad, J.S.6    Shakibaei, M.7
  • 10
    • 44049102307 scopus 로고    scopus 로고
    • A purified extract from clematis mandshurica prevents adenoviral-TRAIL induced apoptosis on rat articular chondrocytes
    • DOI 10.1142/S0192415X08005850, PII S0192415X08005850
    • Lee SW, Lee HJ, Moon JB, Choi SM, Kim DK, Kim IR, Choi WC, Park BS (2008) Purified extract from Clematis mandshurica prevents adenoviral-TRAIL induced apoptosis on rat articular chondrocytes. Am J Chin Med 36:399-410. doi:10.1142/s0192415x08005850 (Pubitemid 351712444)
    • (2008) American Journal of Chinese Medicine , vol.36 , Issue.2 , pp. 399-410
    • Lee, S.W.1    Lee, H.J.2    Moon, J.B.3    Choi, S.M.4    Kim, D.K.5    Kim, I.R.6    Choi, W.C.7    Park, B.S.8
  • 11
    • 54749095969 scopus 로고    scopus 로고
    • 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: The protective role of glutathione-S-transferase
    • doi:10.1186/ar2503
    • Vaillancourt F, Fahmi H, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M (2008) 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase. Arthritis Res Ther 10:R107. doi:10.1186/ar2503
    • (2008) Arthritis Res Ther , vol.10
    • Vaillancourt, F.1    Fahmi, H.2    Shi, Q.3    Lavigne, P.4    Ranger, P.5    Fernandes, J.C.6    Benderdour, M.7
  • 12
    • 72149127646 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways
    • doi:10.1016/j.jep.2009.09.038
    • Ge KL, Chen WF, Xie JX, Wong MS (2010) Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways. J Ethnopharmacol 127:118-123. doi:10.1016/j.jep.2009.09.038
    • (2010) J Ethnopharmacol , vol.127 , pp. 118-123
    • Ge, K.L.1    Chen, W.F.2    Xie, J.X.3    Wong, M.S.4
  • 13
    • 78650415275 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation
    • doi:10.1016/j.neuint.2010.11.004
    • Liu Q, Kou JP, Yu BY (2011) Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation. Neurochem Int 58:119-125. doi:10.1016/j.neuint.2010.11.004
    • (2011) Neurochem Int , vol.58 , pp. 119-125
    • Liu, Q.1    Kou, J.P.2    Yu, B.Y.3
  • 14
    • 84862007373 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway
    • doi:10.1016/j.neuropharm.2012.04.005
    • Wu J, Pan Z, Wang Z, Zhu W, Shen Y, Cui R, Lin J, Yu H, Wang Q, Qian J, Yu Y, Zhu D, Lou Y (2012) Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology 63:349-361. doi:10.1016/j.neuropharm.2012.04.005
    • (2012) Neuropharmacology , vol.63 , pp. 349-361
    • Wu, J.1    Pan, Z.2    Wang, Z.3    Zhu, W.4    Shen, Y.5    Cui, R.6    Lin, J.7    Yu, H.8    Wang, Q.9    Qian, J.10    Yu, Y.11    Zhu, D.12    Lou, Y.13
  • 15
    • 33846890205 scopus 로고    scopus 로고
    • Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    • DOI 10.1016/j.neuropharm.2006.10.001, PII S0028390806003467
    • Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN (2007) Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology 52:827-835. doi:10.1016/j.neuropharm.2006. 10.001 (Pubitemid 46227475)
    • (2007) Neuropharmacology , vol.52 , Issue.3 , pp. 827-835
    • Leung, K.W.1    Yung, K.K.L.2    Mak, N.K.3    Chan, Y.S.4    Fan, T.P.5    Wong, R.N.S.6
  • 16
    • 67650681776 scopus 로고    scopus 로고
    • Panax ginseng C.A. Meyer modulates the levels of MMP3 in S12 murine articular cartilage cell line
    • doi:10.1016/j.jep.2009.05.036
    • Shin JS, Park N, Ra J, Kim Y, Shin M, Hong M, Kim SH, Kwon HJ, Hong SP, Kim J, Bae H (2009) Panax ginseng C.A. Meyer modulates the levels of MMP3 in S12 murine articular cartilage cell line. J Ethnopharmacol 124:397-403. doi:10.1016/j.jep.2009.05.036
    • (2009) J Ethnopharmacol , vol.124 , pp. 397-403
    • Shin, J.S.1    Park, N.2    Ra, J.3    Kim, Y.4    Shin, M.5    Hong, M.6    Kim, S.H.7    Kwon, H.J.8    Hong, S.P.9    Kim, J.10    Bae, H.11
  • 17
    • 84872496291 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes
    • doi:10.1007/s10165-012-0635-8
    • So MW, Lee EJ, Lee HS, Koo BS, Kim YG, Lee CK, Yoo B (2013) Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes. Mod Rheumatol 23:104-111. doi:10.1007/s10165-012-0635-8
    • (2013) Mod Rheumatol , vol.23 , pp. 104-111
    • So, M.W.1    Lee, E.J.2    Lee, H.S.3    Koo, B.S.4    Kim, Y.G.5    Lee, C.K.6    Yoo, B.7
  • 19
    • 76449099412 scopus 로고    scopus 로고
    • Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis
    • doi:10.1186/ar2850
    • Csaki C, Mobasheri A, Shakibaei M (2009) Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther 11:R165. doi:10.1186/ar2850
    • (2009) Arthritis Res Ther , vol.11
    • Csaki, C.1    Mobasheri, A.2    Shakibaei, M.3
  • 20
    • 0028984979 scopus 로고
    • Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats
    • Kang M, Yoshimatsu H, Oohara A, Kurokawa M, Ogawa R, Sakata T (1995) Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats. Physiol Behav 57:393-396
    • (1995) Physiol Behav , vol.57 , pp. 393-396
    • Kang, M.1    Yoshimatsu, H.2    Oohara, A.3    Kurokawa, M.4    Ogawa, R.5    Sakata, T.6
  • 21
    • 46249089246 scopus 로고    scopus 로고
    • Intracerebroventricular ginsenosides are antinociceptive in proinflammatory cytokine-induced pain behaviors of mice
    • doi:10.1007/s12272-001-1165-x
    • Seo YJ, Kwon MS, Choi HW, Jang JE, Lee JK, Sun Y, Jung JS, Park SH, Suh HW (2008) Intracerebroventricular ginsenosides are antinociceptive in proinflammatory cytokine-induced pain behaviors of mice. Arch Pharm Res 31:364-369. doi:10.1007/s12272-001-1165-x
    • (2008) Arch Pharm Res , vol.31 , pp. 364-369
    • Seo, Y.J.1    Kwon, M.S.2    Choi, H.W.3    Jang, J.E.4    Lee, J.K.5    Sun, Y.6    Jung, J.S.7    Park, S.H.8    Suh, H.W.9
  • 22
    • 79955053353 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by beta-amyloid protein
    • doi:10.3109/13880209.2010.521514
    • Gong L, Li SL, Li H, Zhang L (2011) Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by beta-amyloid protein. Pharm Biol 49:501-507. doi:10.3109/13880209.2010.521514
    • (2011) Pharm Biol , vol.49 , pp. 501-507
    • Gong, L.1    Li, S.L.2    Li, H.3    Zhang, L.4
  • 23
    • 84876943372 scopus 로고    scopus 로고
    • Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against beta-amyloid peptide-induced human endothelial cells apoptosis
    • doi:10.1016/j.jep.2013.03.039
    • Yan J, Liu Q, Dou Y, Hsieh Y, Liu Y, Tao R, Zhu D, Lou Y (2013) Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against beta-amyloid peptide-induced human endothelial cells apoptosis. J Ethnopharmacol 147:456-466. doi:10.1016/j.jep. 2013.03.039
    • (2013) J Ethnopharmacol , vol.147 , pp. 456-466
    • Yan, J.1    Liu, Q.2    Dou, Y.3    Hsieh, Y.4    Liu, Y.5    Tao, R.6    Zhu, D.7    Lou, Y.8
  • 24
    • 77952705182 scopus 로고    scopus 로고
    • Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes
    • doi:10.1002/jcb.22604
    • Beier F, Loeser RF (2010) Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J Cell Biochem 110:573-580. doi:10.1002/jcb.22604
    • (2010) J Cell Biochem , vol.110 , pp. 573-580
    • Beier, F.1    Loeser, R.F.2
  • 25
    • 0141592429 scopus 로고    scopus 로고
    • Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1
    • doi:10.1074/jbc.M304857200
    • Oh CD, Chun JS (2003) Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem 278:36563-36571. doi:10.1074/jbc.M304857200
    • (2003) J Biol Chem , vol.278 , pp. 36563-36571
    • Oh, C.D.1    Chun, J.S.2
  • 26
    • 0242522206 scopus 로고    scopus 로고
    • Regulation of apoptosis by Bcl-2 family proteins
    • Burlacu A (2003) Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7:249-257
    • (2003) J Cell Mol Med , vol.7 , pp. 249-257
    • Burlacu, A.1
  • 27
    • 71549172179 scopus 로고    scopus 로고
    • PI-3-K and AKT: Onto the mitochondria
    • doi:10.1016/j.addr.2009.07.017
    • Stiles BL (2009) PI-3-K and AKT: onto the mitochondria. Adv Drug Deliv Rev 61:1276-1282. doi:10.1016/j.addr.2009.07.017
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 1276-1282
    • Stiles, B.L.1
  • 29
    • 84859909950 scopus 로고    scopus 로고
    • 17beta-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl(-) current in rabbit articular chondrocytes
    • doi:10.1111/j.1476-5381.2011.01802.x
    • Kumagai K, Imai S, Toyoda F, Okumura N, Isoya E, Matsuura H, Matsusue Y (2012) 17beta-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl(-) current in rabbit articular chondrocytes. Br J Pharmacol 166:702-720. doi:10.1111/j.1476-5381.2011.01802.x
    • (2012) Br J Pharmacol , vol.166 , pp. 702-720
    • Kumagai, K.1    Imai, S.2    Toyoda, F.3    Okumura, N.4    Isoya, E.5    Matsuura, H.6    Matsusue, Y.7
  • 30
    • 78650834899 scopus 로고    scopus 로고
    • 17beta-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs
    • doi:10.1210/en.2010-0509
    • Zhong M, Carney DH, Boyan BD, Schwartz Z (2011) 17beta-Estradiol regulates rat growth plate chondrocyte apoptosis through a mitochondrial pathway not involving nitric oxide or MAPKs. Endocrinology 152:82-92. doi:10.1210/en.2010-0509
    • (2011) Endocrinology , vol.152 , pp. 82-92
    • Zhong, M.1    Carney, D.H.2    Boyan, B.D.3    Schwartz, Z.4
  • 31
    • 84867820015 scopus 로고    scopus 로고
    • Ginsenoside Rb1 Prevents MPP(?)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK
    • doi:10.1155/2012/693717
    • Hashimoto R, Yu J, Koizumi H, Ouchi Y, Okabe T (2012) Ginsenoside Rb1 Prevents MPP(?)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK. Evid Based Complement Alternat Med 2012:693717. doi:10.1155/2012/ 693717
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 693717
    • Hashimoto, R.1    Yu, J.2    Koizumi, H.3    Ouchi, Y.4    Okabe, T.5
  • 33
    • 84863310849 scopus 로고    scopus 로고
    • Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis
    • doi:10.1016/j.bbrc.2012.06.045
    • Zheng X, Xia C, Chen Z, Huang J, Gao F, Li G, Zhang B (2012) Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochem Biophys Res Commun 423:606-612. doi:10.1016/j.bbrc.2012. 06.045
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 606-612
    • Zheng, X.1    Xia, C.2    Chen, Z.3    Huang, J.4    Gao, F.5    Li, G.6    Zhang, B.7
  • 34
    • 69249148258 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis
    • doi:10.1002/jcb.22233
    • Zhu D, Wu L, Li CR, Wang XW, Ma YJ, Zhong ZY, Zhao HB, Cui J, Xun SF, Huang XL, Zhou Z, Wang SQ (2009) Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem 108:117-124. doi:10.1002/jcb.22233
    • (2009) J Cell Biochem , vol.108 , pp. 117-124
    • Zhu, D.1    Wu, L.2    Li, C.R.3    Wang, X.W.4    Ma, Y.J.5    Zhong, Z.Y.6    Zhao, H.B.7    Cui, J.8    Xun, S.F.9    Huang, X.L.10    Zhou, Z.11    Wang, S.Q.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.