Development of a liquid chromatography tandem mass spectrometry method for the simultaneous determination of zearalenone, deoxynivalenol and their metabolites in pig serum

Mycotoxin Research

Volumn 30, Issue 3, 2014, Pages 171-186

  Brezina, Ulrike ^a,b   Valenta, Hana ^a   Rempe, Inga ^a   Kersten, Susanne ^a   Humpf, Hans Ulrich ^b   Dänicke, Sven ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Deoxynivalenol; LC MS MS; Mycotoxins; Pig serum; Validation; Zearalenone

Indexed keywords

ALPHA ZEARALENOL; BETA ZEARALENOL; DRUG METABOLITE; VOMITOXIN; ZEARALANONE; ZEARALENONE; ZERANOL; TRICHOTHECENE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DETERMINATION; FEMALE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; NEGATIVE ION ELECTROSPRAY; NONHUMAN; SOLID PHASE EXTRACTION COLUMN; STANDARD; SWINE; ANIMAL; BLOOD; METABOLISM; METABOLOMICS; PROCEDURES; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

ANIMALIA; SUIDAE;

ANIMALS; CHROMATOGRAPHY, LIQUID; FEMALE; LIMIT OF DETECTION; METABOLOMICS; REPRODUCIBILITY OF RESULTS; SWINE; TANDEM MASS SPECTROMETRY; TRICHOTHECENES; ZEARALENONE;

EID: 84905091642     PISSN: 01787888     EISSN: 18671632     Source Type: Journal    
DOI: 10.1007/s12550-014-0200-8     Document Type: Article

References (42)

1. 2002/657/EC CD The Commission of the European Communities. Commision decision of 12 August 2002 implementing council directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. The Official Journal of the European Communities L221:8-36
2. 2006/576/EC CR The Commission of the European Communities. Commission recommendation of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratotin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. The Official Journal of the European Union L 229:7-9
3. Annesley TM, Clayton LT (2009) Ultraperformance liquid chromatography-tandem mass spectrometry assay for iohexol in human serum. Clin Chem 55(6):1196-1202. doi:10.1373/clinchem.2008.121533
4. Ansermot N, Brawand-Amey M, Eap CB (2012) Simultaneous quantification of selective serotonin reuptake inhibitors and metabolites in human plasma by liquid chromatography-electrospray mass spectrometry for therapeutic drug monitoring. J Chromatogr B Anal Technol Biomed Life Sci 885:117-130. doi:10.1016/j.jchromb.2011.12.028
5. Dänicke S, Brezina U (2013) Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over. Food Chem Toxicol 60:58-75. doi:10.1016/j.fct. 2013.07.017
6. Dänicke S, Döll S, Goyarts T, Seeling K, Valenta H, Ueberschär K (2008) Metabolism, kinetics and occurrence of deoxynivalenol (DON) and zearalenone (ZON) in physiological samples of pigs, ruminants and poultry. In: Oswald IP, Taranu I (eds) Mycotoxins in farm animals. Transworld Research Network, Trivandrum, pp 235-273
7. De Baere S, Goossens J, Osselaere A, Devreese M, Vandenbroucke V, De Backer P, Croubels S (2011) Quantitative determination of T-2 toxin, HT-2 toxin, deoxynivalenol and deepoxy-deoxynivalenol in animal body fluids using LC-MS/MS detection. J Chromatogr B Anal Technol Biomed Life Sci 879(24):2403 -2415. doi:10.1016/j.jchromb.2011.06.036
8. De Baere S, Osselaere A, Devreese M, Vanhaecke L, De Backer P, Croubels S (2012)Development of a liquid-chromatography tandem mass spectrometry and ultra-high-performance liquid chromatography high-resolution mass spectrometry method for the quantitative determination of zearalenone and its major metabolites in chicken and pig plasma. Anal Chim Acta 756:37-48. doi:10.1016/j.aca.2012.10.027
9. Devreese M, De Baere S, De Backer P, Croubels S (2012) Quantitative determination of several toxicological important mycotoxins in pig plasma using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods. J Chromatogr A 1257:74-80. doi:10.1016/j.chroma.2012.08.008
10. Dirtu AC, Roosens L, Geens T, Gheorghe A, Neels H, Covaci A (2008) Simultaneous determination of bisphenol A, triclosan, and tetrabromobisphenol A in human serumusing solid-phase extraction and gas chromatography-electron capture negative-ionization mass spectrometry. Anal Bioanal Chem 391(4):1175-1181. doi:10.1007/s00216-007-1807-9
11. Döll S, Dänicke S (2011) The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding. Prev Vet Med 102(2):132-145. doi:10.1016/j.prevetmed.2011.04.008
12. Döll S, Dänicke S, Ueberschär KH, Valenta H, Schnurrbusch U, Ganter M, Klobasa F, Flachowsky G (2003) Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch Anim Nutr Archiv Tierernähr 57(5):311-334. doi:10.1080/00039420310001607680
13. Ediage EN, Di Mavungu JD, Song S, Wu A, Van Peteghem C, De Saeger S (2012) A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry. Anal Chim Acta 741:58-69. doi:10.1016/j.aca.2012.06.038
14. EFSA (2004a) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to deoxynivalenol (DON) as undesirable substance in animal feed. EFSA J 73:1-42
15. EFSA (2004b) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to zearalenone as undesirable substance in animal feed. EFSA J 89:1-35
16. Emotte C, Heudi O, Deglave F, Bonvie A, Masson L, Picard F, Chaturvedi A, Majumdar T, Agarwal A, Woessner R, Kretz O (2012) Validation of an on-line solid-phase extraction method coupled to liquid chromatography-tandemmass spectrometry detection for the determination of Indacaterol in human serum. J Chromatogr B Anal Technol Biomed Life Sci 895:1-9. doi:10.1016/j.jchromb.2012. 02.025
17. FDA (2001) Guidance for industry: bioanalytical method validation. U.S. Department of Health and Human Services, Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), May 2001, BP
18. Gambacorta L, Solfrizzo M, Visconti A, Powers S, Cossalter AM, Pinton P, Oswald IP (2013) Validation study on urinary biomarkers of exposure for aflatoxin B-1, ochratoxin A, fumonisin B-1, deoxynivalenol and zearalenone in piglets. World Mycotoxin J 6(3):299-308. doi:10.3920/Wmj2013.1549
19. Goyarts T, Brüssow KP, Valenta H, Tiemann U, Jäger K, Dänicke S (2010) On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation. Mycotoxin Res 26(2):119-131. doi:10.1007/s12550-010-0047-6
20. Jodlbauer J, Zöllner P, Lindner W (2000) Determination of zeranol, taleranol, zearalenone, alpha- and beta-zearalenol in urine and tissue by high-performance liquid chromatography-tandem mass spectrometry. Chromatographia 51(11-12):681-687. doi:10.1007/bf02505405 (Pubitemid 30434934)
21. Kromidas S, Klinkner R, Mertens R (1995) Method validation in the analytical laboratory. Nachr Chem Tech Lab 43(6):669-676
22. Meky FA, Turner PC, Ashcroft AE, Miller JD, Qiao YL, Roth MJ, Wild CP (2003) Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem Toxicol 41(2):265-273 (Pubitemid 35447876)
23. Olsen M, Malmlof K, Pettersson H, Sandholm K, Kiessling KH (1985) Plasma and urinary levels of zearalenone and alpha-zearalenol in a prepubertal gilt fed zearalenone. Acta Pharmacol Toxicol 56(3):239-243 (Pubitemid 15149191)
24. Ramos JJ, Gomara B, Fernandez MA, Gonzalez MJ (2007) A simple and fast method for the simultaneous determination of polychlorinated biphenyls and polybrominated diphenyl ethers in small volumes of human serum. J Chromatogr A 1152(1-2):124-129. doi:10.1016/j.chroma.2006.12.050 (Pubitemid 46753998)
25. Razzazi-Fazeli E, Bohm J, Jarukamjorn K, Zentek J (2003) Simultaneous determination of major B-trichothecenes and the de-epoxy-metabolite of deoxynivalenol in pig urine and maize using high-performance liquid chromatography-mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 796(1):21-33 (Pubitemid 38352706)
26. Rempe I, Brezina U, Kersten S, Dänicke S (2013a) Effects of a Fusarium toxin-contaminated maize treated with sodium metabisulphite, methylamine and calcium hydroxide in diets for female piglets. Arch Anim Nutr. doi:10.1080/1745039X.2013.818762
27. Rempe I, Kersten S, Brezina U, Hermeyer K, Beineke A, Dänicke S (2013b) Time-dependent effects of graded levels of Fusarium toxin-contaminated maize in diets for female piglets. World Mycotoxin J 6(1):51-63. doi:10.3920/Wmj2012.1494
28. Rychlik M, Asam S (2008) Stable isotope dilution assays in mycotoxin analysis. Anal Bioanal Chem 390(2):617-628. doi:10.1007/s00216-007-1717-x
29. Shin BS, Hong SH, Hwang SW, Kim HJ, Lee JB, Yoon HS, do Kim J, Yoo SD (2009) Determination of zearalenone by liquid chromatography/tandem mass spectrometry and application to a pharmacokinetic study. Biomed Chromatogr 23(9):1014-1021. doi:10.1002/bmc.1217
30. Solfrizzo M, Gambacorta L, Lattanzio VM, Powers S, Visconti A (2011) Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, alpha and beta-zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Anal Bioanal Chem 401(9):2831-2841. doi:10.1007/s00216-011-5354-z
31. Song SQ, Ediage EN, Wu AB, De Saeger S (2013) Development and application of salting-out assisted liquid/liquid extraction for multimycotoxin biomarkers analysis in pig urine with high performance liquid chromatography/tandem mass spectrometry. J Chromatogr A 1292:111-120. doi:10.1016/j.chroma.2012.10.071
32. Sorensen LK, Elbaek TH (2005) Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 820(2):183-196 (Pubitemid 40724584)
33. Sottani C, Leoni E, Porro B, Montagna B, Amatu A, Sottotetti F, Quaretti P, Poggi G, Minoia C (2009) Validation of an LC-MS/MS method for the determination of epirubicin in human serum of patients undergoing drug eluting microsphere-transarterial chemoembolization (DEM-TACE). J Chromatogr B Anal Technol Biomed Life Sci 877(29):3543-3548. doi:10.1016/j.jchromb.2009.08.054
34. Sypecka Z, Kelly M, Brereton P (2004) Deoxynivalenol and zearalenone residues in eggs of laying hens fed with a naturally contaminated diet: effects on egg production and estimation of transmission rates from feed to eggs. J Agric Food Chem 52(17):5463- 5471
35. Thieu N, Pettersson H (2009) Zearalenone, deoxynivalenol and aflatoxin B1 and their metabolites in pig urine as biomarkers for mycotoxin exposure. Mycotoxin Res 25(2):59-66
36. Turner PC, Burley VJ, Rothwell JA, White KL, Cade JE, Wild CP (2008a) Deoxynivalenol: rationale for development and application of a urinary biomarker. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25(7):864-871. doi:10.1080/02652030801895040 (Pubitemid 351917194)
37. Turner PC, Rothwell JA, White KL, Gong Y, Cade JE, Wild CP (2008b) Urinary deoxynivalenol is correlated with cereal intake in individuals from the United Kingdom. Environ Health Perspect 116(1):21-25. doi:10.1289/ehp.10663
38. Valenta H, Dänicke S, Döll S (2003) Analysis of deoxynivalenol and de-epoxy-deoxynivalenol in animal tissues by liquid chromatography after clean-up with an immunoaffinity column. Mycotoxin Res 19(1):51-55. doi:10.1007/bf02940093
39. Versilovskis A, Geys J, Huybrechts B, Goossens E, De Saeger S, Callebaut A (2012) Simultaneous determination of masked forms of deoxynivalenol and zearalenone after oral dosing in rats by LC-MS/MS. World Mycotoxin J 5(3):303-318. doi:10.3920/Wmj2012.1411
40. Warth B, Sulyok M, Fruhmann P, Mikula H, Berthiller F, Schuhmacher R, Hametner C, Abia WA, Adam G, Froehlich J, Krska R (2012) Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Commun Mass Spectrom 26(13):1533-1540. doi:10.1002/rcm.6255
41. Zöllner P, Mayer-Helm B (2006) Trace mycotoxin analysis in complex biological and foodmatrices by liquid chromatography-atmospheric pressure ionisation mass spectrometry. J Chromatogr A 1136(2):123-169. doi:10.1016/j.chroma.2006.09.055 (Pubitemid 44809126)
42. Zöllner P, Jodlbauer J, Kleinova M, Kahlbacher H, Kuhn T, Hochsteiner W, Lindner W (2002) Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and liver samples of pigs fed with mycotoxin-contaminated oats. J Agric Food Chem 50(9):2494-2501 (Pubitemid 34437357)