On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation

Mycotoxin Research

Volumn 26, Issue 2, 2010, Pages 119-131

  Goyarts, Tanja ^a   Brüssow, Klaus Peter ^b   Valenta, Hana ^a   Tiemann, Ute ^b   Jäger, Kathrin ^c   Dänicke, Sven ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Deoxynivalenol; Fetus; Fusarium toxin; Intraperitoneal infusion; Per os; Sow

Indexed keywords

MYCOTOXIN; VOMITOXIN;

ANIMAL EXPERIMENT; ANIMAL HEALTH; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD PLACENTA BARRIER; BLOOD SAMPLING; CELL PROLIFERATION; CESAREAN SECTION; CONTROLLED STUDY; FEMALE; FERTILITY; FETUS; FOOD CONTAMINATION; FUSARIUM; GESTATION PERIOD; HISTOPATHOLOGY; LEUKOCYTE COUNT; LIVER; MONOCYTE; NEUTROPHIL COUNT; NONHUMAN; ORGANOGENESIS; OSMOTIC MINIPUMP; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA HALF LIFE; PREGNANCY; SOW (SWINE); SPLEEN; TOXICOKINETICS;

FUSARIUM;

EID: 77955657703     PISSN: 01787888     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12550-010-0047-6     Document Type: Article

References (34)

1. Alm H, Brüssow K-P, Torner H, Vanselow J, Tomek W, Dänicke S, Tiemann U (2006) Influence of Fusarium-toxin contaminated feed on initial quality and meiotic competence of gilt oocytes. Reprod Toxicol 22:44-50.
2. Brüssow K-P, Ratky J, Kanitz W, Becker F (1990) Determination of the duration of ovulation in gilts by means of laparoscopy. Reprod Dom Anim 25:184-190.
3. Dänicke S, Valenta H, Klobasa F, Döll S, Ganter M, Flachowsky G (2004) Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch Anim Nutr 58:1-17.
4. Dänicke S, Brüssow K-P, Valenta H, Ueberschär K-H, Tiemann U, Schollenberger M (2005) On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone. Mol Nutr Food Res 49:932-943.
5. Dänicke S, Brüssow KP, Goyarts T, Valenta H, Ueberschär KH, Tiemann U (2007) On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from the sow to the full-term piglet during the last third of gestation. Food Chem Toxicol 45:1565-1574.
6. Dost FH (1968) Grundlagen der Pharmakokinetik, 2nd edn. Georg Thieme, Stuttgart, Germany.
7. Fink-Gremmels J, Malekinejad H (2007) Clinical effects and biochemical mechanisms associated with exposure to the mycoestrogen zearalenone. Anim Feed Sci Tech 137:326-341.
8. 1 mouse. Food Chem Toxicol 25:155-162.
9. Forsyth DM, Yoshizawa T, Morooka N, Tuite J (1977) Emetic and refusal activity of deoxynivalenol to swine. Appl Env Microbiol 34:547-552.
10. Friend DW, Trenholm HL, Elliot JI, Thompson BK, Hartin KE (1982) Effect of feeding vomitoxin-contaminated wheat to pigs. Can J Anim Sci 62:1211-1222.
11. Goyarts T, Dänicke S (2006) Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicol Lett 163:171-182.
12. Goyarts T, Dänicke S, Rothkötter H-J, Spilke J, Tiemann U, Schollenberger M (2005) On the effects of a chronic deoxynivalenol intoxication on performance, haematological and serum parameters of pigs when diets are offered either for ad libitum consumption or fed restrictively. J Vet Med A 52:305-314.
13. Goyarts T, Dänicke S, Grove N, Tiemann U, Rothkötter H-J (2006a) Methodical aspects of in vitro proliferation of porcine blood lymphocytes when exposed to deoxynivalenol (DON). Landbauforsch Völk 56:139-148. (Pubitemid 44379095)
14. Goyarts T, Dänicke S, Tiemann U, Rothkötter H-J (2006b) Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol in vitro 20:858-867.
15. Goyarts T, Dänicke S, Brüssow KP, Valenta H, Ueberschär KH, Tiemann U (2007a) On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35-70 of gestation. Toxicol Lett 171:38-49. (Pubitemid 46990666)
16. Goyarts T, Dänicke S, Valenta H, Ueberschär K-H (2007b) Carry over of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from naturally contaminated wheat in the pig. Food Addit Contam 24:369-380.
17. Hörügel K, Hanschmann G, Vergara H (2003) Begleitende Untersuchungen zum Einsatz eines Mykotoxinbinders in Sauenbeständen im Freistaat Sachsen. Berichte aus der Tierproduktion, Sächsische Landesanstalt für Landwirtschaft 8:82-90.
18. Hussein HS, Brasel JM (2001) Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167:101-134.
19. Jadamus A, Schneider D (2002) Long-term effect of fusariotoxins on the reproduction performance of sows testing the effectiveness of detoxifying feed additives. Feed Magazin 10:396-405.
20. Masuda T, Kasai T, Satodate R (1993) Quantitative measurement of hemosiderin deposition in tissue sections of the liver by image analysis. Anal Quant Cytol Histol 15:379-382.
21. Naumann C, Bassler R (1993) Die chemische Untersuchung von Futtermitteln. VDLUFA, Darmstadt.
22. Placinta CM, D'Mello JPF, Macdonald AMC (1999) A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim Feed Sci Tech 78:21-37.
23. Prelusky DB (1997) Effect of intraperitoneal infusion of deoxynivalenol on feed consumption and weight gain in the pig607. Nat Toxins 5:121-125.
24. Ratky J, Brüssow K-P, Solti L (1998) Endoscopic methods in swine reproductive research: A review. Acta Vet Hung 46:492.
25. SAS Institute (2003) SAS/Stat® User's Guide Release 9.1 Edn. SAS, Cary, NC.
26. StatSoft (1995) Statistica for the Windows, Version 7.1. Tulsa, OK.
27. Sugita-Konishi Y, Pestka JJ (2001) Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model. J Toxicol Env Health 64:619-636.
28. Tiemann U, Dänicke S (2007) In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review. Food Addit Contam 24:306-314.
29. Tiemann U, Schneider F, Tuchscherer A (1996) Effects of organochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol 70:490-496.
30. Tiemann U, Brüssow K-P, Jonas L, Pöhland R, Schneider F, Dänicke S (2006) Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts. J Anim Sci 84:236-245. (Pubitemid 44405748)
31. Tiemann U, Brüssow KP, Dannenberger D, Jonas L, Pöhland R, Jäger K, Dänicke S, Hagemann E (2008a) The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation. Toxicol Lett 179:113-117.
32. Tiemann U, Brüssow KP, Küchenmeister U, Jonas L, Pöhland R, Reischauer A, Jäger K, Dänicke S (2008b) Changes in the spleen and liver of pregnant sows and full-term piglets after feeding diets naturally contaminated with deoxynivalenol and zearalenone. Vet J 176:188-196.
33. Uzarski RL, Islam Z, Pestka JJ (2003) Potentiation of trichotheceneinduced leukocyte cytotoxicity and apoptosis by TNF-alpha and Fas activation. Chemico-Biological Interactions 146:105-119.
34. Valenta H, Dänicke S, Döll S (2003) Analysis of deoxynivalenol and de-epoxy-deoxynivalenol in animal tissues by liquid chromatography after clean-up with an immunoaffinity column. Mycotox Res 19:51-55.