Validation study on urinary biomarkers of exposure for aflatoxin B1, ochratoxin A, fumonisin B1, deoxynivalenol and zearalenone in piglets

World Mycotoxin Journal

Volumn 6, Issue 3, 2013, Pages 299-308

  Gambacorta, S ^a   Solfrizzo, M ^a   Visconti, A ^a   Powers, S ^b   Cossalter, A M ^c   Pinton, P ^c   Oswald, I P ^c  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^b VICAM   (United States)

^c TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

bioavailability; dose response; excretion; urine

Indexed keywords

AFLATOXIN; BETA GLUCURONIDASE; BIOLOGICAL MARKER; FUMONISIN B1; OCHRATOXIN; VOMITOXIN; ZEARALENONE;

AGRICULTURAL SLURRY; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CORRELATION COEFFICIENT; DOSE RESPONSE; FREEZE DRYING; HYDROLYSIS; LIQUID CHROMATOGRAPHY; NONHUMAN; PIGLET; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDATION STUDY;

FUNGI;

EID: 84882937192     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2013.1549     Document Type: Article

References (48)

1. Avantaggiato, G., Solfrizzo, M. and Visconti, A., 2005. Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins. Food Additives and Contaminants 22: 379-388. (Pubitemid 40723773)
2. Blank, R. and Wolffram, S., 2004. Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs. Journal of Nutrition 134: 2355-2358. (Pubitemid 39201608)
3. Boudergue, C., Burel, C., Dragacci, S., Favrot, M.C., Fremy, J.M., Massimi, C., Prigent, P., Debongnie, P., Pussemier, L., Boudra, H., Morgavi, D., Oswald, I., Perez, A. and Avantaggiato, G., 2009. Review of mycotoxin-detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety. Scientific report submitted to EFSA. Available at: http://www.scribd.com/doc/58481519/EFSA-Report-on-Mycotoxin-Detoxifying-Agents- 2. http://www.scribd.com/doc/ 58481519/EFSA-Report-on-Mycotoxin-Detoxifying-Agents-2
4. Council for Agricultural Science and Technology (CAST), 2003. Mycotoxins: risks in plant, animal and human systems. Task force report No. 139. CAST, Ames, IA, USA.
5. Dänicke, S., Brüssow, K.P., Valenta, H., Ueberschär, K.H., Tiemann, U. and Schollenberger, M., 2005. On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone. Molecular Nutrition and Food Research 49: 932-943. (Pubitemid 41501272)
6. Dänicke, S., Goyarts, T., Valenta, H., Razzazi, E. and Böhm, J., 2004c. On the effects of deoxynivalenol (DON) in pig feed on growth performance, nutrients utilization and DON metabolism. Journal of Animal and Feed Sciences 13: 539-556. (Pubitemid 40084426)
7. Dänicke, S., Valenta, H., Döll, S., Ganter, M. and Flachowsky, G., 2004a. On the effectiveness of a detoxifying agent in preventing fusario-toxicosis in fattening pigs. Animal Feed Science and Technology 114: 141-157. (Pubitemid 38484820)
8. Dänicke, S., Valenta, H., Klobasa, F., Döll, S., Ganter, M. and Flachowsky, G., 2004b. Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Archives of Animal Nutrition 58: 1-17. (Pubitemid 38597301)
9. De Andrés, F., Zougagh, M., Castañeda, G. and Ríos, A., 2008. Determination of zearalenone and its metabolites in urine samples by liquid chromatography with electrochemical detection using a carbon nanotube-modified electrode. Journal of Chromatography A 1212: 54-60.
10. Dilkin, P., Direito, G., Sismas, M.M.S., Mallman, C.A. and Corrêa, B., 2010. Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material. Chemico-Biological Interactions 185: 157-162.
11. Dilkin, P., Zorzete, P., Mallmann, C.A., Gomes, J.D.F., Utiyama, C.E., Oetting, L.L. and Corrêa, B., 2003. Toxicological effects of chronic low doses of aflatoxin B1 and fumonisin B1-containing Fusarium moniliforme culture material in weaned piglets. Food and Chemical Toxicology 41: 1345-1353. (Pubitemid 37289183)
12. Ediage, E.N., Di Mavungu, J.D., Song, S., Wu, A., Van Peteghem, C. and De Saeger, S., 2012. An LC-MS/MS method for multi-detection of mycotoxin biomarkers in human urine. Analytica Chimica Acta 741: 58-69.
13. Eriksen, G.S., Pettersson, H. and Lindberg, J.E., 2003. Absorption, metabolism and excretion of 3-acetyl DON in pigs. Archives of Animal Nutrition 57: 335-345.
14. European Commission (EC), 2003. Commission Directive 2003/100/EC of 31 October 2003 amending Annex I to Directive 2002/32/EC of the European Parliament and of the Council on undesirable substances in animal feed. Official Journal of the European Union L285: 33-37.
15. European Commission (EC), 2006. Commission Recommendation 2006/576/EC of 17 August 2006 on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official Journal of the European Union L229: 7-9.
16. European Committee for Standardisation (CEN), 2006. EN/ISO 17375. Determination of aflatoxin B1. CEN, Brussels, Belgium.
17. European Committee for Standardisation (CEN), 2009. EN 15791. Determination of deoxynivalenol in animal feed-HPLC method with immunoaffinity column clean-up. CEN, Brussels, Belgium.
18. European Committee for Standardisation (CEN), 2009. EN 15792. Determination of zearalenone in animal feed-High performance liquid chromatographic method with fluorescence detection and immunoaffinity column clean-up. CEN, Brussels, Belgium.
19. European Committee for Standardisation (CEN), 2012. EN 16006. Determination of the sum of fumonisin B1 & B2 in compound animal feed with immunoaffinity clean-up and RP-HPLC with fluorescence detection after pre-or post-column derivatisation. CEN, Brussels, Belgium.
20. European Committee for Standardisation (CEN), 2012. EN 16007. Determination of ochratoxin A in animal feed by immunoaffinity column clean-up and high performance liquid chromatography with fluorescence detection. CEN, Brussels, Belgium.
21. European Food Safety Authority (EFSA), 2010. Statement on the establishment of guidelines for the assessment of additives from the functional group 'substances for reduction of the contamination of feed by mycotoxins'. EFSA Journal 8: 1693.
22. Fodor, J., Balogh, K., Weber, M., Méézes, M., Kametler, L., Póósa, R., Mamet, R., Bauer, L., Horn, P., Kováács, F. and Kováács, M., 2008. Absorption, distribution and elimination of fumonisin B1 metabolites in weaned piglets. Food Additives and Contaminants Part A 25: 88-96. (Pubitemid 350201284)
23. Fodor, J., Meyer, K., Riedlberger, M., Bauer, J., Horn, P., Kovacs, F. and Kovacs, M., 2006. Distribution and elimination of fumonisin analogues in weaned piglets after oral administration of Fusarium verticillioides fungal culture. Food Additives and Contaminants 23: 492-501. (Pubitemid 43675284)
24. Goyarts, T. and Dänicke, S., 2006. Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicology Letters 163: 171-182.
25. Grenier, B. and Oswald, I.P., 2011. Mycotoxin co-contamination of foods and feeds: meta-analysis of publications describing toxicological interactions. World Mycotoxin Journal 4: 285-313.
26. Ho, C.C., 1987. The metabolites of aflatoxins B1 and G1 in the pig urine. Journal of the Chinese Society of Veterinary Science 13: 197-201.
27. MacDougald, O., Thulin, A. and Pestka, J., 1990. Determination of zearalenone and related metabolites in porcine urine by modified enzyme-linked immunosorbent assay. Journal of AOAC International 73: 65-68.
28. Meissonnier, G.M., Raymond, I., Laffitte, J., Cossalter, A.M., Pinton, P., Benoit, E., Bertin G., Galtier, P. and Oswald, I.P., 2009. Dietary glucomannan improves the vaccinal response in pigs exposed to AFB1 or T-2 toxin. World Mycotoxin Journal 2: 161-172.
29. Olsen, M.E., Petterson, H.I. and Sandholm, K.A., 1985. Quantitative liquid chromatographic method using fluorescence detection for determining zearalenone and its metabolites in blood plasma and urine. Journal of AOAC International 68: 632-635. (Pubitemid 16220078)
30. Polychronaki, N., Wild, C.P., Mykkänen, H., Amra, H., Abdel-Wahhab, M., Sylla, A., Diallo, M., El-Nezami, H. and Turner, P.C., 2008. Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea. Food and Chemical Toxicology 46: 519-526.
31. 14C-labelled deoxynivalenol in swine. Fundamental and Applied Toxicology 10: 276-286. (Pubitemid 18068023)
32. Prelusky, D.B., Trenholm, H.L. and Savard, M.E., 1994. Pharmacokinetic fate of 14C-labelled fumonisin B1 in swine. Natural Toxins 2: 73-80.
33. Scott, P.M., 2005. Biomarkers of human exposure to ochratoxin A. Food Additives and Contaminants 22: 99-107. (Pubitemid 44574579)
34. Shephard, G.S., Van der Westhuizen, L. and Sewram, V., 2007. Biomarkers of exposure to fumonisin mycotoxins: a review. Food Additives and Contaminants 24: 1196-1201. (Pubitemid 47471159)
35. Solfrizzo, M., Carratù, M.R., Avantaggiato, G., Galvano, F., Pietri, A. and Visconti, A., 2001b. Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin contaminated diets. Food and Chemical Toxicology 39: 507-511. (Pubitemid 32323985)
36. Solfrizzo, M., Gambacorta, L., Lattanzio, M.T.V., Powers, S. and Visconti, A., 2011. Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, and zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Analytical and Bioanalytical Chemistry 401: 2831-2841.
37. Solfrizzo, M., Visconti, A., Avantaggiato, G., Torres, A. and Chulze, S., 2001a. In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisins. Mycopathologia 151: 147-153. (Pubitemid 32961469)
38. Stoev, S.D., Paskalev, M., MacDonald, S. and Mantle, P.G., 2002. Experimental one year ochratoxin A toxicosis in pigs. Experimental and Toxicological Pathology 53: 481-487. (Pubitemid 34204959)
39. Stoev, S.D., Stoeva, J.K., Anguelov, G., Hald, B., Creppy, E.E. and Radic, B., 1998. Haematological, biochemical and toxicological investigations in spontaneous cases with different frequency of porcine nephropathy in Bulgaria. Journal of Veterinary Medicine A 45: 229-236. (Pubitemid 128530602)
40. Stoev, S.D., Vitanov, S., Anguelov, G., Petkova-Bocharova, T. and Creppy, E.E., 2001. Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid. Veterinary Research Communications 25: 205-223.
41. Streit, E., Schatzmayr, G., Tassis, P., Tzika, E., Marin, D., Taranu, I., Tabuc, C., Nicolau, A., Aprodu, I., Puel, O. and Oswald, I.P., 2012. Current situation of mycotoxin contamination and co-occurrence in animal feed-focus on Europe. Toxins 4: 788-809.
42. Szabó-Fodor, J., Kametler, L., Pósa, R., Mamet, R., Rajli, V., Bauer, J., Horn, P., Kovács, F. and Kovács, M., 2008. Kinetics of fumonisin B1 in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration. Cereal Research Communications 36: 331-336.
43. Thieu, N.Q. and Petterson, H., 2009. Zearalenone, deoxynivalenol and aflatoxin B1 and their metabolites in urine as biomarkers for mycotoxin exposure. Mycotoxin Research 25: 59-66.
44. Thieu, N.Q., 2010. Evaluation of the exposure of pigs to mycotoxins by their biomarkers. In: Proceedings of the 4th Biomin World Nutrition Forum. Biomin, Salzburg, Austria, pp. 67-72.
45. Turner, P.C., Flannery, B., Isitt, C., Ali, M. and Pestka, J., 2012. The role of biomarkers in evaluating human health concerns from fungal contaminants in food. Nutrition Research Reviews 25: 162-179.
46. Turner, P.C., White, K.L., Burley, V.J., Hopton, R.P., Rajendram, A., Fisher, J., Cade, J.E. and Wild, C.P., 2010. A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers 15: 553-562.
47. Warth, B., Sulyok, M., Fruhmann, P., Mikula, H., Berthiller, F., Schuhmacher, R., Hametner, C., Abia, W.A., Adam, G., Fröhlich, J. and Krska, R., 2012. Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Communications in Mass Spectrometry 26: 1533-1540.
48. Zöllner, P., Jodlbauer, J., Kleinova, M., Kahlbacher, H., Kuhn, T., Hochsteiner, W. and Lindner, W., 2002. Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and liver samples of pigs fed with mycotoxin-contaminated oats. Journal of Agricultural and Food Chemistry 50: 2494-2501. (Pubitemid 34437357)