Src regulates the activity of SIRT2

Biochemical and Biophysical Research Communications

Volumn 450, Issue 2, 2014, Pages 1120-1125

  Choi, You Hee ^a   Kim, Hangun ^b   Lee, Sung Ho ^a   Jin, Yun Hye ^a   Lee, Kwang Youl ^a  

^a Chonnam National University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

Phosphorylation; Protein level; SIRT2; Src

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; SIRTUIN 2; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DEACETYLATION; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

MAMMALIA;

PHOSPHORYLATION; PROTEIN LEVEL; SIRT2; SRC;

HEK293 CELLS; HUMANS; MCF-7 CELLS; PHOSPHORYLATION; SIRTUIN 2; SRC-FAMILY KINASES;

EID: 84905083382     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.06.117     Document Type: Article

References (31)

1. G. Blander, and L. Guarente The Sir2 family of protein deacetylases Annu. Rev. Biochem. 73 2004 417 435 (Pubitemid 39050375)
2. M. Hernick, and C.A. Fierke Zinc hydrolases: the mechanisms of zinc-dependent deacetylases Arch. Biochem. Biophys. 433 2005 71 84 (Pubitemid 39586584)
3. R. Marmorstein Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deacetylases Biochem. Soc. Trans. 32 2004 904 909 (Pubitemid 39655500)
4. A. Vaquero, M. Scher, D. Lee, H. Erdjument-Bromage, P. Tempst, and D. Reinberg Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin Mol. Cell 16 2004 93 105 (Pubitemid 39330155)
5. J. Luo, A.Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu Negative control of p53 by Sir2alpha promotes cell survival under stress Cell 107 2001 137 148 (Pubitemid 33035941)
6. G. Afshar, and J.P. Murnane Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2 Gene 234 1999 161 168 (Pubitemid 29294100)
7. Y.H. Jin, Y.J. Kim, D.W. Kim, K.H. Baek, B.Y. Kang, C.Y. Yeo, and K.Y. Lee Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53 Biochem. Biophys. Res. Commun. 368 2008 690 695
8. Y. Han, Y.H. Jin, Y.J. Kim, B.Y. Kang, H.J. Choi, D.W. Kim, C.Y. Yeo, and K.Y. Lee Acetylation of Sirt2 by p300 attenuates its deacetylase activity Biochem. Biophys. Res. Commun. 375 2008 576 580
9. B. Peck, C.Y. Chen, K.K. Ho, P. Di Fruscia, S.S. Myatt, R.C. Coombes, M.J. Fuchter, C.D. Hsiao, and E.W. Lam SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2 Mol. Cancer Ther. 9 2010 844 855
10. E. Jing, S. Gesta, and C.R. Kahn SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation Cell Metab. 6 2007 105 114 (Pubitemid 47163621)
11. K.M. Rothgiesser, S. Erener, S. Waibel, B. Luscher, and M.O. Hottiger SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310 J. Cell Sci. 123 2010 4251 4258
12. Y. Li, H. Matsumori, Y. Nakayama, M. Osaki, H. Kojima, A. Kurimasa, H. Ito, S. Mori, M. Katoh, M. Oshimura, and T. Inoue SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis Genes Cells 16 2011 34 45
13. H.S. Kim, A. Vassilopoulos, R.H. Wang, T. Lahusen, Z. Xiao, X. Xu, C. Li, T.D. Veenstra, B. Li, H. Yu, J. Ji, X.W. Wang, S.H. Park, Y.I. Cha, D. Gius, and C.X. Deng SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity Cancer Cell 20 2011 487 499
14. M.T. Brown, and J.A. Cooper Regulation, substrates and functions of src Biochim. Biophys. Acta 1287 1996 121 149 (Pubitemid 26189191)
15. R. Roskoski Jr. Src protein-tyrosine kinase structure and regulation Biochem. Biophys. Res. Commun. 324 2004 1155 1164 (Pubitemid 40292143)
16. C.V. Ferreira, G.Z. Justo, A.C. Souza, K.C. Queiroz, W.F. Zambuzzi, H. Aoyama, and M.P. Peppelenbosch Natural compounds as a source of protein tyrosine phosphatase inhibitors: application to the rational design of small-molecule derivatives Biochimie 88 2006 1859 1873 (Pubitemid 44881192)
17. S.C. Bae, and Y.H. Lee Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation Gene 366 2006 58 66 (Pubitemid 43199594)
18. B.J. North, and E. Verdin Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation J. Biol. Chem. 282 2007 19546 19555 (Pubitemid 47100062)
19. Y.H. Choi, H. Kim, S.H. Lee, Y.H. Jin, and K.Y. Lee ERK1/2 regulates SIRT2 deacetylase activity Biochem. Biophys. Res. Commun. 437 2013 245 249
20. J.H. Kim, K. Kim, H.M. Jin, I. Song, B.U. Youn, S.H. Lee, Y. Choi, and N. Kim Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1 J. Biol. Chem. 285 2010 5224 5231
21. B.J. North, B.L. Marshall, M.T. Borra, J.M. Denu, and E. Verdin The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase Mol. Cell 11 2003 437 444 (Pubitemid 36293837)
22. M.C. Haigis, and L.P. Guarente Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction Genes Dev. 20 2006 2913 2921 (Pubitemid 44771725)
23. S.C. Dryden, F.A. Nahhas, J.E. Nowak, A.S. Goustin, and M.A. Tainsky Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle Mol. Cell Biol. 23 2003 3173 3185 (Pubitemid 36459231)
24. T. Inoue, Y. Nakayama, H. Yamada, Y.C. Li, S. Yamaguchi, M. Osaki, A. Kurimasa, M. Hiratsuka, M. Katoh, and M. Oshimura SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest Cell Cycle 8 2009 1279 1291
25. T. Inoue, M. Hiratsuka, M. Osaki, and M. Oshimura The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation Cell Cycle 6 2007 1011 1018 (Pubitemid 46708571)
26. C.L. Brooks, and W. Gu The impact of acetylation and deacetylation on the p53 pathway Protein Cell 2 2011 456 462
27. M.H. Yang, G. Laurent, A.S. Bause, R. Spang, N. German, M.C. Haigis, and K.M. Haigis HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS Mol. Cancer Res. 11 2013 1072 1077
28. C.M. Southwood, M. Peppi, S. Dryden, M.A. Tainsky, and A. Gow Microtubule deacetylases, SirT2 and HDAC6, in the nervous system Neurochem. Res. 32 2007 187 195 (Pubitemid 46238864)
29. T.Y. Eom, and R.S. Jope GSK3 beta N-terminus binding to p53 promotes its acetylation Mol. Cancer 8 2009 14
30. A. Goc, B. Al-Husein, K. Katsanevas, A. Steinbach, U. Lou, H. Sabbineni, D.L. Deremer, and P.R. Somanath Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo Oncotarget 5 2014 775 787
31. E.J. Park, H.J. Chung, H.J. Park, G.D. Kim, Y.H. Ahn, and S.K. Lee Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells Food Chem. Toxicol. 55 2013 424 433