The stability and degradation pathway of recombinant human parathyroid hormone: Deamidation of asparaginyl residue and peptide bond cleavage at aspartyl and asparaginyl residues

Pharmaceutical Research

Volumn 14, Issue 12, 1997, Pages 1685-1690

  Nabuchi, Yoshiaki ^a   Fujiwara, Eri ^a   Kuboniwa, Hitoshi ^a   Asoh, Yoshinori ^a   Ushio, Hidetoshi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Asparaginyl; Aspartyl; Cleavage; Deamidation; Human parathyroid hormone

Indexed keywords

AMINO ACID; ASPARAGINE; ASPARTIC ACID; PARATHYROID HORMONE; PEPTIDE; RECOMBINANT HORMONE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CHEMICAL BOND; DRUG DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE MAPPING; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACIDS; ASPARAGINE; ASPARTIC ACID; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; TEMPERATURE; TRYPSIN;

EID: 0031414571     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012115426306     Document Type: Article

References (23)

1. G. N. Hendy, H. M. Kronenberg, J. T. Potts, Jr., and A. Rich. Proc. Natl. Acad. Sci. USA 78:7365-7369 (1981).
2. J. T. Potts, Jr., H. M. Kronenberg, and M. Rosenblatt. Adv. Protein Chem. 35:323-396 (1982).
3. L. Mosekilde, C. H. Søgaard, C. C. Danielsen, O. Tørring, and M. H. L. Nilsson. Endocrinology 129:421-428 (1991).
4. T. J. Gardella, D. Rubin, A. B. A. Samra, H. T. Keutmann, J. T. Potts Jr., H. M. Kronenberg, and S. R. Nussbaum. J. Biol. Chem. 265:15854-15859 (1990).
5. Y. Nabuchi, E. Fujiwara, K. Ueno, H. Kuboniwa, Y. Asoh, and H. Ushio. Pharm. Res. 12:2049-2052 (1995).
6. A. L. Frelinger, III and J. E. Zull. J. Biol. Chem. 259:5507-5513 (1984).
7. Z. Shahrokh, G. Eberlein, D. Buckley, M. V. Paranandi, D. W. Aswad, P. Stratton, R. Mischak, and Y. J. Wang. Pharm. Res. 11:936-944 (1994).
8. K. Patel and R. T. Borchardt. Pharm. Res. 7:703-711 (1990).
9. R. C. Stephenson and S. Clarke. J. Biol. Chem. 264:6164-6170 (1989).
10. K. Patel and T. Borchardt. Pharm. Res. 7:787-793 (1990).
11. T. Geiger and S. Clarke. J. Biol. Chem. 262:785-794 (1987).
12. R. T.-Cross and V. Schirch. J. Biol. Chem. 266:22549-22556 (1991).
13. C. E. M. Voorter, W. A. de Haard-Hoekman, P. J. M van den Oetelaar, H. Bloemendal, and W. W. de Jong. J. Biol. Chem. 263:19020-19023 (1988).
14. E. E. Haley, B. J. Corcoran, F. E. Dorer, and D. L. Buchanan. Biochemistry 5:3229-3235 (1966).
15. A. B. Robinson. Proc. Natl. Acad. Sci. USA 71:885-888 (1974).
16. A. B. Robinson and C. J. Rudd. Current Top. Cell. Regul. 8:247-295 (1974).
17. D. Piszkiewicz, M. Landon, and E. L. Smith. Biochem. Biophys. Res. Commun. 40:1173-1178 (1970).
18. Y. Nabuchi, H. Kuboniwa, H. Takasu, Y Asoh, and H. Ushio. Rapid Commun. Mass Spectrom. 9:257-260 (1995).
19. V. Wary, T. Federau, W. Gronwald, H. Mayer, D. Schomburg, W. Tegge, and E. Wingender. Biochemistry 33:1684-1693 (1994).
20. W. Gronwald, D. Schomburg, V. M. P. Harder, H. Mayer, J. Paulsen, E. Wingender, and V. Wary. Biol. Chem. Hoppe-Seyler 377:175-186 (1996).
21. C. Oliyai and R. T. Borchardt. Pharm. Res. 10:95-102 (1993).
22. M. Landon. Methods Enzymol. 47:145-149 (1977).
23. K. Patel and R. T. Borchardt. Pharm. Res. 7:787-793 (1990).