Trypsin resistance of a decapeptide KISS1R agonist containing an N ω-methylarginine substitution

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6328-6332

  Asami, Taiji ^a   Nishizawa, Naoki ^a   Ishibashi, Yoshihiro ^a   Nishibori, Kimiko ^a   Horikoshi, Yasuko ^a   Matsumoto, Hirokazu ^a   Ohtaki, Tetsuya ^a   Kitada, Chieko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

KISS1R agonist; Kisspeptin; Metastin; Metastin analog; Metastin(45 54); Serum stability; Trypsin resistance

Indexed keywords

G PROTEIN COUPLED RECEPTOR 54; G PROTEIN COUPLED RECEPTOR 54 AGONIST; KISSPEPTIN; METASTIN; METASTIN DERIVATIVE; N(G) METHYLARGININE; PEPTIDE DERIVATIVE; PROTEIN KINASE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CELL LEVEL; CELL MIGRATION; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; RECEPTOR AFFINITY; REPRODUCTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ARGININE; HUMANS; KISSPEPTINS; RECEPTORS, G-PROTEIN-COUPLED; TRYPSIN;

EID: 84866732615     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.087     Document Type: Article

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