Association of central serotonin transporter availability and body mass index in healthy Europeans

European Neuropsychopharmacology

Volumn 24, Issue 8, 2014, Pages 1240-1247

  Hesse, Swen ^a,b   van de Giessen, Elsmarieke ^c   Zientek, Franziska ^a   Petroff, David ^a,d   Winter, Karsten ^e   Dickson, John C ^f   Tossici Bolt, Livia ^g   Sera, Terez ^h   Asenbaum, Susanne ⁱ   Darcourt, Jacques ^j   Akdemir, Umit O ^k   Knudsen, Gitte M ^l   Nobili, Flavio ^m   Pagani, Marco ^n,o   Vander Borght, Thierry ^p   Van Laere, Koen ^q   Varrone, Andrea ^r   Tatsch, Klaus ^s,t   Sabri, Osama ^a,b   Booij, Jan ^c  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d Centre for Clinical Studies   (Germany)

^e Translational Centre for Regenerative Medicine (TRM)   (Germany)

^f UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^g UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^h UNIVERSITY OF SZEGED   (Hungary)

ⁱ MEDICAL UNIVERSITY OF VIENNA   (Austria)

^j CENTRE ANTOINE LACASSAGNE   (France)

^k GAZI UNIVERSITY   (Turkey)

^l University of Copenhagen   (Denmark)

^m UNIVERSITY OF GENOA   (Italy)

ⁿ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^o INSTITUTE OF COGNITIVE SCIENCES AND TECHNOLOGIES   (Italy)

^p UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^q UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^r KAROLINSKA INSTITUTE   (Sweden)

^s UNIVERSITY OF MUNICH   (Germany)

^t Municipal Hospital of Karlsruhe Inc   (Germany)

more..

Author keywords

5 HTT; BMI; FP CIT; Obesity; Serotonin; SPECT

Indexed keywords

IODINE 123; SEROTONIN TRANSPORTER; 2-CARBOMETHOXY-8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)TROPANE; SLC6A4 PROTEIN, HUMAN; TROPANE DERIVATIVE;

ADULT; AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; FEMALE; HUMAN; HYPOTHALAMUS; MALE; MESENCEPHALON; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS; VOXEL BASED MORPHOMETRY; BRAIN; BRAIN MAPPING; EUROPE; METABOLISM; MIDDLE AGED; SCINTISCANNING; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; BRAIN; BRAIN MAPPING; EUROPE; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES; YOUNG ADULT;

EID: 84905041212     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2014.05.005     Document Type: Article

References (38)

1. Bertrand R.L., Senadheera S., Tanoto A., Tan K.L., Howitt L., Chen H., Murphy T.V., Sandow S.L., Liu L., Bertrand P.P. Serotonin availability in rat colon is reduced during a Western diet model of obesity. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303(3):G424-434.
2. 123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects. J. Nucl. Med. 2007, 48(3):359-366.
3. Chen X., Margolis K.J., Gershon M.D., Schwartz G.J., Sze J.Y. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PLoS One 2012, 7(3):e32511.
4. Chen P.S., Yang Y.K., Yeh T.L., Lee I.H., Yao W.J., Chiu N.T., Lu R.B. Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers - a SPECT study. NeuroImage 2008, 40(1):275-279.
5. 123I-FP-CIT SPECT database. Eur. J. Nucl. Med. Mol. Imaging 2012, 39(1):188-197.
6. Erritzoe D., Frokjaer V.G., Haahr M.T., Kalbitzer J., Svarer C., Holst K.K., Hansen D.L., Jernigan T.L., Lehel S., Knudsen G.M. Cerebral serotonin transporter binding is inversely related to body mass index. NeuroImage 2010, 52(1):284-289.
7. Fuemmeler B.F., Agurs-Collins T.D., McClernon F.J., Kollins S.H., Kail M.E., Bergen A.W., Ashley-Koch A.E., Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring) 16 (2), 2008, 348-355.
8. Haahr M.E., Rasmussen P.M., Madsen K., Marner L., Ratner C., Gillings N., Baaré W.F., Knudsen G.M. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. NeuroImage 2012, 61(4):884-888.
9. Hainer V., Kabrnova K., Aldhoon B., Kunesova M., Wagenknecht M. Serotonin and norepinephrine reuptake inhibition and eating behavior. Ann. N. Y. Acad. Sci. 2006, 1083:252-269.
10. Hesse S., Ballaschke O., Barthel H., Sabri O. Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder. Psychiatry Res. 2009, 171(2):120-128.
11. Hesse S., Barthel H., Murai T., Müller U., Müller D., Seese A., Kluge R., Sabri O. Is correction for age necessary in neuroimaging studies of the central serotonin transporter?. Eur. J. Nucl. Med. Mol. Imaging 2003, 30(3):427-430.
12. Hesse S., Villringer A., Naegler K., Bresch A., Schönknecht P., Becker G.A., Luthardt J., Patt M., Faßhauer M., Möller F., Stumvoll M., Brust P., Hegerl U., Sabri O. In vivo serotonin transporter (SERT) availability as a link between obesity and depression. Eur. J. Nucl. Med. Mol. Imaging 2009, 36(Suppl. 2):S386.
13. Hoebel B.G. Brain neurotransmitters in food and drug reward. Am. J. Clin. Nutr. 1985, 42(Supplement):S1133-S1150.
14. Homberg J.R., la Fleur S.E., Cuppen E. Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity (Silver Spring) 2010, 18(1):137-145.
15. Horstmann A., Busse F.P., Mathar D., Müller K., Lepsien J., Schlögl H., Kabisch S., Kratzsch J., Neumann J., Stumvoll M., Villringer A., Pleger B. Obesity-related differences between women and men in brain structure and goal-directed behavior. Front. Hum. Neurosci. 2011, 10(5):58.
16. 2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study. Brain Res. 2004, 1018(2):227-235.
17. 123I-FP-CIT SPECT in healthy, male subjects. J. Nucl. Med. 2012, 53(7):1087-1090.
18. Koskela A.K., Kaurijoki S., Pietiläinen K.H., Karhunen L., Pesonen U., Kuikka J.T., Kaprio J., Rissanen A. Serotonin transporter binding and acquired obesity - an imaging study of monozygotic twin pairs. Physiol. Behav. 2008, 93(4-5):724-732.
19. Lam D.D., Garfield A.S., Marston O.J., Shaw J., Heisler L.K. Brain serotonin system in the coordination of food intake and body weight. Pharmacol. Biochem. Behav. 2010, 97(1):84-91.
20. Lan M.Y., Chang Y.Y., Chen W.H., Kao Y.F., Lin H.S., Liu J.S. Serotonin transporter gene promoter polymorphism is associated with body mass index and obesity in non-elderly stroke patients. J. Endocrinol. Investig. 2009, 32(2):119-122.
21. 1A receptors after intravenous citalopram in human. Synapse 2012, 66(10):880-884.
22. Praschak-Rieder N., Wilson A.A., Hussey D., Carella A., Wei C., Ginovart N., Schwarz M.J., Zach J., Houle S., Meyer J.H. Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol. Psychiatry 2005, 58(10):825-830.
23. Price J.L., Drevets W.C. Neurocircuitry of mood disorders. Neuropsychopharmacology 2010, 35(1):192-216.
24. R Development Core Team, 2011. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN: 3-900051-07-0. http://www.R-project.org/.
25. Ramamoorthy S., Shippenberg T.S., Jayanthi L.D. Regulation of monoamine transporters: role of transporter phosphorylation. Pharmacol. Ther. 2011, 129(2):220-238.
26. Ratner C., Ettrup A., Bueter M., Haahr M.E., Compan V., le Roux C.W., Levin B., Hansen H.H., Knudsen G.M. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring) 2012, 20(10):2133-2141.
27. 123I]β-CIT SPECT in major depressive disorder versus controls: effect of season and gender. Eur. J. Nucl. Med. Mol. Imaging 2009, 36(5):841-849.
28. Sookoian S., Gianotti T.F., Gemma C., Burgueño A., Pirola C.J. Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults. Obesity (Silver Spring) 2008, 16(2):488-491.
29. 123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 2001, 41(4):275-284.
30. Sturm R. The effects of obesity, smoking, and drinking on medical problems and costs. Health Aff. (Millwood) 2002, 21(2):245-253.
31. 11C-DASB in healthy humans. Neuropsychopharmacology 2010, 35(3):741-751.
32. 123I-FP-CIT SPECT normal database. Eur. J. Nucl. Med. Mol. Imaging 2011, 38(8):1529-1540.
33. Uçeyler N., Schütt M., Palm F., Vogel C., Meier M., Schmitt A., Lesch K.P., Mössner R., Sommer C. Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity. Int. J. Obes. (Lond.) 2010, 34(4):701-711.
34. van de Giessen E., Hesse S., Caan M.W.A., Zientek F., Dickson J.C., Tossici-Bolt L., Sera T., Asenbaum S., Guignard R., Akdemir U.O., Knudsen G.M., Nobili F., Pagani M., Vander Borght T., Van Laere K., Varrone A., Tatsch K., Booij J., Sabri O. No association between striatal DAT binding and BMI: A multi-center European study in healthy volunteers. NeuroImage 2013, 40(1):143-144.
35. 123I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur. J. Nucl. Med. Mol. Imaging 2013, 40(2):213-227.
36. Volkow N.D., Wang G.J., Baler R.D. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn. Sci. 2011, 15(1):37-46.
37. Zhao J., Goldberg J., Vaccarino V. Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study. Int. J. Obes. (Lond.) 2013, 37(1):140-145.
38. 123I-PE2I. J. Nucl. Med. 2010, 51(12):1885-1891.