Is correction for age necessary in neuroimaging studies of the central serotonin transporter?

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 30, Issue 3, 2003, Pages 427-430

  Hesse, Swen ^a   Barthel, Henryk ^a,d   Murai, Toshiya ^c   Müller, Ulrich ^b   Müller, Dominic ^a   Seese, Anita ^a   Kluge, Regine ^a   Sabri, Osama ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c KYOTO UNIVERSITY   (Japan)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Age; Ageing; Serotonin transporter; SPET; 123I CIT

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; IODINE 123; RADIOPHARMACEUTICAL AGENT; SEROTONIN TRANSPORTER;

ADULT; AGED; AGING; ARTICLE; BRAIN STEM; FEMALE; HUMAN; HYPOTHALAMUS; MALE; MESENCEPHALON; NEURORADIOLOGY; NEUROTRANSMISSION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SEROTONINERGIC SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

EID: 0037870262     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-1044-6     Document Type: Article

References (15)

1. Meltzer CC, Smith G, DeKosky ST, et al. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology 1998; 18:407-430.
2. Arranz B, Eriksson A, Mellerup E, et al. Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain Res 1992; 620:162-166.
3. Tauscher J, Verhoeff NP, Christensen BK, et al. Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. Neuropsychopharmacology 2001; 24:522-530.
4. Andersson A, Sundman I, Marcusson J. Age stability of human brain 5-HT terminals studied with [3H]paroxetine binding. Gerontology 1992; 38:127-132.
5. Pirker W, Asenbaum S, Hauk M, et al. Imaging serotonin and dopamine transporters with 1231-β-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med 2000; 41:36-44.
6. van Dyck CH, Malison RT, Seibyl JP, et al. Age-related decline in central serotonin transporter availability with [123I]βCIT SPECT. Neurobiol Aging 2000; 21:497-501.
7. Kuikka JT, Tammela L, Bergström KA, et al. Effects of ageing on serotonin transporters in healthy females. Eur J Nucl Med 2001; 28:911-913.
8. Dahlström M, Ahonen A, Ebeling H, et al. Elevated hypothalamic/midbrain serotonin (monoamine) transporter availability in depressive drug-naive children and adolescents. Mol Psychiatry 2000; 5:514-522.
9. Müller U, Wächter T, Barthel H, et al. Striatal [123I]β-CIT SPECT and prefrontal cognitive functions in Parkinson's disease. J Neural Transm 2000; 107:303-319.
10. Barthel H, Sorger D, Kühn HJ, et al. Differential alteration of the nigrostriatal dopaminergic system in Wilson's disease investigated with [123I]β-CIT and high-resolution SPET. Eur J Nucl Med 2001; 28:1656-1663.
11. Talairach J, Tournoux P. Co-planar stereotactic atlas of the human brain. Stuttgart, New York: Thieme, 1988.
12. Murai T, Müller U, Werheid K, et al. In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. J Neuropsychiatry Clin Neurosci 2001; 13:222-228.
13. Okada T, Fujita M, Shimada S, et al. Assessment of affinities of β-CIT, β-CIT-FE, and β-CIT-FP for monoamine transporters permanently expressed in cell lines. Nucl Med Biol 1998; 25:53-58.
14. Olivier B, Soudijn W, van Wijngaarden I. Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors. Prog Drug Res 2000; 54:59-119.
15. Staley JK, Krishnan-Sarin S, Zoghbi S, et al. Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse 2001; 41:275-284.