Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific

Free Radical Biology and Medicine

Volumn 74, Issue , 2014, Pages 200-209

  Castro, M Leticia ^a   McConnell, Melanie J ^a   Herst, Patries M ^b  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Antioxidant capacity; Cell cycle arrest; DNA repair; Glioblastoma multiforme; High dose ascorbate; Radiation

Indexed keywords

ASCORBIC ACID; REACTIVE OXYGEN METABOLITE; RADIOSENSITIZING AGENT;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL REGENERATION; CELL SURVIVAL; CELL VIABILITY; CLONOGENESIS; CLONOGENIC ASSAY; COLONY FORMING UNIT; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENDOTHELIUM CELL; G2 PHASE CELL CYCLE CHECKPOINT; GLIA CELL; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IONIZING RADIATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIZATION; SINGLE STRANDED DNA BREAK; CFU COUNTING; CHEMORADIOTHERAPY; DRUG EFFECTS; GLIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RADIATION RESPONSE; TUMOR CELL LINE;

ASCORBIC ACID; CELL LINE, TUMOR; CELL SURVIVAL; CHEMORADIOTHERAPY; COLONY-FORMING UNITS ASSAY; DNA REPAIR; ENDOTHELIAL CELLS; G2 PHASE CELL CYCLE CHECKPOINTS; GLIOBLASTOMA; HUMANS; NEUROGLIA; OXIDATIVE STRESS; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES;

EID: 84905015451     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.06.022     Document Type: Article

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