Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket

Journal of Medicinal Chemistry

Volumn 57, Issue 14, 2014, Pages 5949-5964

  Hong, Fang Tsao ^a   Norman, Mark H ^a   Ashton, Kate S ^a   Bartberger, Michael D ^b   Chen, Jie ^c   Chmait, Samer ^b   Cupples, Rod ^c   Fotsch, Christopher ^a   Jordan, Steven R ^b   Lloyd, David J ^c   Sivits, Glenn ^c   Tadesse, Seifu ^a   Hale, Clarence ^c   St Jean, David J ^a  

^a Departments of Medicinal Chemistry   (United States)

^b Molecular Structure   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPOUND 51; GLUCOKINASE; PYRIDINE DERIVATIVE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IC 50; MOUSE; NONHUMAN; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOKINASE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERAZINES; PROTEIN BINDING; PYRIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905002556     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5001979     Document Type: Article

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